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3,5-Bis(trifluoromethyl)benzoic acid

3,5-Bis(trifluoromethyl)benzoic acid structure

CAS No.: 725-89-3

Chemical Name:: 3,5-Bis(trifluoromethyl)benzoic acid

Synonyms: 3,5-DI(TRIFLUOROMETHYL)BENZOIC ACID;MBT-BOA;RARECHEM AL BO 0001;TIMTEC-BB SBB000963;3,5-Di-(Trifluoromethyl)Benzoi;3,5-Bis(trifluoromethyl)benzoic;3,5-bis(trifluoromethyl)-benzoicaci;BIS(3,5-TRIFLUOROMETHYL)BENZOIC ACID;3,5-BIS(TRIFLUOROMETHYL)BENZOIC ACID;3, 5-Bis (trifluoromrthyl) benzoic acid

CBNumber:: CB0255912

Molecular Formula:: C9H4F6O2

Molecular Weight:: 258.12

MDL Number:: MFCD00000388

MOL File:: 725-89-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:25:27

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3,5-Bis(trifluoromethyl)benzoic acid Properties

Melting point	142-143 °C(lit.)
Boiling point	223.9±40.0 °C(Predicted)
Density	1,42 g/cm³
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
form	Solid
pka	3.34±0.10(Predicted)
color	White to Off-White
Water Solubility	Slightly soluble in water.
BRN	2058600
InChI	InChI=1S/C9H4F6O2/c10-8(11,12)5-1-4(7(16)17)2-6(3-5)9(13,14)15/h1-3H,(H,16,17)
InChIKey	HVFQJWGYVXKLTE-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
CAS DataBase Reference	725-89-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	NN52L84T3A
NIST Chemistry Reference	3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

RTECS

DG4448020

HazardClass

IRRITANT

HS Code

29163990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

3,5-Bis(trifluoromethyl)benzoic acid price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	232882	3,5-Bis(trifluoromethyl)benzoic acid 98%	725-89-3	5g	$40	2026-04-30	Buy
Sigma-Aldrich	232882	3,5-Bis(trifluoromethyl)benzoic acid 98%	725-89-3	25g	$155	2026-04-30	Buy
TCI Chemical	B1420	3,5-Bis(trifluoromethyl)benzoic Acid >98.0%(GC)(T)	725-89-3	25g	$134	2026-04-30	Buy
TRC	TRC-T790630-5G	3,5-Bis(trifluoromethyl)benzoic Acid	725-89-3	5g	$59	2026-06-03	Buy
TRC	TRC-T790630-25G	3,5-Bis(trifluoromethyl)benzoic Acid	725-89-3	25g	$167	2026-06-03	Buy

Product number	Packaging	Price	Buy
232882	5g	$40	Buy
232882	25g	$155	Buy
B1420	25g	$134	Buy
TRC-T790630-5G	5g	$59	Buy
TRC-T790630-25G	25g	$167	Buy

3,5-Bis(trifluoromethyl)benzoic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

3,5-Bis(trifluoromethyl)benzoic acid is a useful synthetic intermediate, and is a derivative of Benzoic acid (B203900). 3,5-Bis(trifluoromethyl)benzoic acid has also been identified as a major metabolite of a series of 3,5-bis(trifluoromethyl)benzyl ethers in vitro, and is hypothesized to result via oxidation of the benzylic position.

Application

3,5-bis(trifluoromethyl)benzoic acid is an intermediate in synthesizing pharmaceutical compounds, which are substance P (neurokinin-1) receptor antagonists. In particular, such compounds are substance P (neurokinin-1) receptor antagonists, which are helpful, e.g., in treating inflammatory diseases, psychiatric disorders, and emesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 68, p. 3695, 2003 DOI: 10.1021/jo026903n

General Description

3,5-Bis(trifluoromethyl)benzoic acid is a significant metabolite formed during metabolism of 3,5-bis(trifluoromethyl)benzyl ether via oxidation.

Synthesis

The synthesis of 3,5-bis(trifluoromethyl)benzoic acid was carried out by 1,3-dibromo-5,5-dimethyl-acetonitrile urea with 1,3-bis(trifluoromethyl)benzene to produce 3,5-bis(trifluoromethyl)bromobenzene in 98% yield and 99% selectivity. Then 3,5-bis(trifluoromethyl)bromobenzene was used as raw material to synthesize 3,5-bis(trifluoromethyl)benzoic acid in more than 72% yield.

3,5-Bis(trifluoromethyl)benzoic acid synthesis

Synthesis of 3,5-Bis(trifluoromethyl)benzoic acid from Carbon dioxide and 3,5-Bis(trifluoromethyl)bromobenzene

3,5-Bis(trifluoromethyl)benzoic acid Preparation Products And Raw materials

Raw materials

3,5-Bis(trifluoromethyl)styrene 1,3,5-Tris(trifluoromethyl)benzene 3,5-Bis(trifluoromethyl)iodobenzene Benzoyl fluoride, 3,5-bis(trifluoromethyl)- 1,3-Bis(trifluoromethyl)-benzene

3,5-Bis(trifluoromethyl)benzoyl chloride carbon monoxide Carbon dioxide 3,5-Bis(trifluoromethyl)bromobenzene

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Preparation Products

3,5-Bis(trifluoromethyl)phenylacetonitrile 3,5-Bis(trifluoromethyl)benzaldehyde 2,4-Bis(trifluoromethyl)benzoic acid

3,5-Bis(trifluoromethyl)benzoic acid Suppliers

Global( 401)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Leaderherb Bio-Tech. Co., LTD.	51288246 13366708252	300abc@sina.com	China	91	58
BEIJING GOLDEN OLIVE COMPANY	15311296095	mary@goldolive.com	China	86	58
Zaozhuang Benefit Chemical Co., Ltd.	0531-69958783 15508681609	1948129184@qq.com	China	208	60
Enki Biopharmaceuticals(Shanghai) Limited	+86-21 5768 0965 +86-13916707528	yusu@enkibiopharma.com	China	47	55
Hunan Furui Biopharma Technology Co., Ltd.	15901640172，19275032510 15901640172	sales03@hn-furui.com	China	380	55
Qingdao Rongrong Chemical Technology Co., Ltd	15224422002	2467602940@qq.com	China	33	58
Shanghai Fuchunle Biotechnology Co., Ltd.	15902102743 18121362927	shelley@fortunabiotech.com	China	108	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66

Supplier	Advantage
Beijing Leaderherb Bio-Tech. Co., LTD.	58
BEIJING GOLDEN OLIVE COMPANY	58
Zaozhuang Benefit Chemical Co., Ltd.	60
Enki Biopharmaceuticals(Shanghai) Limited	55
Hunan Furui Biopharma Technology Co., Ltd.	55
Qingdao Rongrong Chemical Technology Co., Ltd	58
Shanghai Fuchunle Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66

The specific synthesis method of 3,5-bis(trifluoromethyl)benzoic acid
?3,5-bis(trifluoromethyl)benzoic acid is an intermediate in synthesizing compounds with pharmacological activity.
Jul 12,2024

View Lastest Price from 3,5-Bis(trifluoromethyl)benzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	3,5-bis(Trifluoromethyl)benzoic acid 725-89-3	$130.00	1KG	99%	300MT/year	Speranza Chemical Co., Ltd.
2026-09-10	3,5-Bis(trifluoromethyl)benzoic acid 725-89-3		1kg	99.0%HPLC	30000	Enki Biopharmaceuticals (Shanghai) Limited
2026-08-25	3,5-Bis(trifluoromethyl)benzoic acid 725-89-3	$1.10-9.90	1KG	99%min	100KG	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

3,5-bis(Trifluoromethyl)benzoic acid
725-89-3
$130.00
99%
Speranza Chemical Co., Ltd.

3,5-Bis(trifluoromethyl)benzoic acid
725-89-3
99.0%HPLC
Enki Biopharmaceuticals (Shanghai) Limited

3,5-Bis(trifluoromethyl)benzoic acid
725-89-3
$1.10-9.90
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

3,5-Bis(trifluoromethyl)benzoic acid Spectrum

3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)MS 3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)¹HNMR 3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)¹³CNMR 3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)IR1 3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)IR2 3,5-Bis(trifluoromethyl)benzoic acid(725-89-3)Raman

725-89-3(3,5-Bis(trifluoromethyl)benzoic acid)Related Search:

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3, 5-Bis (trifluoromrthyl) benzoic acid 3,5-BIS(TRIFLUOROMETHYL)BENZOIC ACID, 98 % 3,5-Di-(Trifluoromethyl)Benzoi 3,5-Di(trifluoromethyl)benzoic acid , TECH 3,5-Bis(trifluoroMethyl)benzoic acid, 98% 5GR 3,5-Di(trifluoroMethyl)benzoic acid, 90, TECH 3,5-bis(trifluoromethyl)-benzoicaci 3,5-BIS(TRIFLUOROMETHYL)BENZOIC ACID 3,5-DI(TRIFLUOROMETHYL)BENZOIC ACID MBT-BOA BIS(3,5-TRIFLUOROMETHYL)BENZOIC ACID RARECHEM AL BO 0001 TIMTEC-BB SBB000963 Benzoic acid, 3,5-bis(trifluoromethyl)- 3,5-Bis(trifluoromethyl)benzoic Acid > 3,5-Bis(trifluoromethyl)benzoic 725-89-3 C9H4O2F6 C9H3F6O2 Carboxylic Acids Carbonyl Compounds C9 Building Blocks Organic Building Blocks CARBOXYLIC ACID Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Miscellaneous Benzotrifluoride Series Boronic Acid series Fluorobenzene Fluorides C9 Carbonyl Compounds Carboxylic Acids 1