N-(3-Chloropropyl)piperidine hydrochloride
- CAS No.
- 5472-49-1
- Chemical Name:
- N-(3-Chloropropyl)piperidine hydrochloride
- Synonyms
- PIPERIDINOPROPYL CHLORIDE HCL;N-(3-CHLOROPROPYL)PIPERIDINE HCL;1-(3-CHLOROPROPYL)PIPERIDINE HCL 98%;piperidinopropylchloride,hydrochloride;1-(3-CHLOROPROPYL) PIPERIDINE HYDROCHLO&;1-(3-chloropropyl)-piperidinhydrochloride;3-Piperidinopropyl Chloride Hydrochloride;N-(3-CHLOROPROPYL)PIPERIDINE?HYDROCHLORID;1-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE;N-(3-Chloropropyl)piperidine hydrochloride
- CBNumber:
- CB0258362
- Molecular Formula:
- C8H17Cl2N
- Molecular Weight:
- 198.13
- MDL Number:
- MFCD00012838
- MOL File:
- 5472-49-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 219-223 °C(lit.) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Water Solubility | Soluble in water |
| form | Powder or Crystalline Powder |
| color | White to yellow |
| InChI | InChI=1S/C8H16ClN.ClH/c9-5-4-8-10-6-2-1-3-7-10;/h1-8H2;1H |
| InChIKey | OBOBUDMMFXRNDO-UHFFFAOYSA-N |
| SMILES | N1(CCCCl)CCCCC1.Cl |
| CAS DataBase Reference | 5472-49-1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TM6498600 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
N-(3-Chloropropyl)piperidine hydrochloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 596310 | 1-(3-Chloropropyl)piperidine monohydrochloride 97% | 5472-49-1 | 10g | $166 | 2023-06-20 | Buy |
| TCI Chemical | C2922 | 1-(3-Chloropropyl)piperidine Hydrochloride >98.0%(T) | 5472-49-1 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | C2922 | 1-(3-Chloropropyl)piperidine Hydrochloride >98.0%(T) | 5472-49-1 | 5g | $84 | 2026-04-30 | Buy |
| Chem-Impex | 44576 | 1-(3-Chloropropyl)piperidine hydrochloride ≥98%(Assaybytitration) | 5472-49-1 | 1G | $55.28 | 2026-05-19 | Buy |
| Chem-Impex | 44576 | 1-(3-Chloropropyl)piperidine hydrochloride ≥98%(Assaybytitration) | 5472-49-1 | 5G | $196.19 | 2026-05-19 | Buy |
N-(3-Chloropropyl)piperidine hydrochloride Chemical Properties, Uses, Production
Uses
1-(3-Chloropropyl)piperidine Hydrochloride is used in preparation of Triazolotriazine derivatives as A2A receptor antagonists.
Synthesis
110-89-4
109-70-6
5472-49-1
Hexahydropyridine (piperidine, 0.45 g, 5.3 mmol) and 1-bromo-3-chloropropane (5.2 g, 33 mmol) were dissolved in toluene (17.5 mL) and then tetra-n-ammonium hydrogensulfate (ammonium hydrogensulfate, 0.51 g, 1.5 mmol) and 25% aqueous sodium hydroxide solution (10 mL) were added. The reaction mixture was stirred at 40 °C for 3 hours. After completion of the reaction, the mixture was cooled to room temperature, the toluene layer was separated, washed with saturated aqueous sodium chloride solution and dried over anhydrous sodium sulfate. After removal of sodium sulfate by filtration, hydrochloric acid/methanol solution (2 mL) was added to the filtrate and the mixture was subsequently concentrated. The resulting crude product was purified by recrystallization from methanol/ether to give N-(3-chloropropyl)piperidine hydrochloride (0.96 g, 91% yield) as white crystals.
References
[1] Patent: US6642228, 2003, B1. Location in patent: Page/Page column 76-77
N-(3-Chloropropyl)piperidine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Titan Enterprise Development Co., Ltd | 16621224781 | syy@titansci.com | China | 2893 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
View Latest Price from N-(3-Chloropropyl)piperidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-02 | N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
5472-49-1
|
$1.00 | 1KG | 95-99% | 500kg/month | Career Henan Chemical Co |
-
- N-(3-CHLOROPROPYL)PIPERIDINE HYDROCHLORIDE
5472-49-1
- $1.00
- 95-99%
- Career Henan Chemical Co
N-(3-Chloropropyl)piperidine hydrochloride Spectrum
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