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3-Chloro-1-propanol

3-Chloro-1-propanol Structure
3-Chloro-1-propanol structure
CAS No.
627-30-5
Chemical Name:
3-Chloro-1-propanol
Synonyms
3-CHLOROPROPAN-1-OL;3-Chloropropanol;TRIMETHYLENE CHLOROHYDRIN;3-Chloropropanol-1;1-Propanol, 3-chloro-;3-Chloropropyl alcohol;1-CHLORO-3-HYDROXYPROPANE;NSC 60190;oro-1-propanoL;Chloro-1-propa
CBNumber:
CB2407458
Molecular Formula:
C3H7ClO
Molecular Weight:
94.54
MDL Number:
MFCD00002943
MOL File:
627-30-5.mol
MSDS File:
SDS
Last updated:2026-08-25 08:01:45
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3-Chloro-1-propanol Properties

Melting point -20 °C
Boiling point 160-162 °C(lit.)
Density 1.131 g/mL at 25 °C(lit.)
refractive index n20/D 1.445(lit.)
Flash point 164 °F
storage temp. 0-6°C
solubility 50g/l (slow decomposition)
form Liquid
pka 14.73±0.10(Predicted)
Specific Gravity 1.14
color Clear colorless to yellow
PH 3-4 (100g/l, H2O, 20℃)
Water Solubility 300 g/L (20 ºC)
BRN 773655
Henry's Law Constant 1.3×101 mol/(m3Pa) at 25℃, Ebert et al. (2023)
Exposure limits No exposure limit is set. A TLV-TWA air value of 100 ppm (approximately 400 mg/m3) is suggested for this compound.
Stability Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents.
InChI 1S/C3H7ClO/c4-2-1-3-5/h5H,1-3H2
InChIKey LAMUXTNQCICZQX-UHFFFAOYSA-N
SMILES OCCCCl
CAS DataBase Reference 627-30-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 148011U61G
NIST Chemistry Reference 1-Propanol, 3-chloro-(627-30-5)
EPA Substance Registry System 3-Chloro-1-propanol (627-30-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H315-H319-H341-H335-H227
Precautionary statements  P501-P270-P202-P261-P210-P201-P271-P264-P280-P302+P352-P370+P378-P308+P313-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P304+P340+P312-P403+P233-P403+P235-P405
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-36/37/39
RIDADR  UN 2849
WGK Germany  3
RTECS  UA8930000
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29055910
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

3-Chloro-1-propanol price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C46403 3-Chloro-1-propanol 98% 627-30-5 25g $51.3 2026-04-30 Buy
Sigma-Aldrich C46403 3-Chloro-1-propanol 98% 627-30-5 100g $108 2026-04-30 Buy
TCI Chemical C0270 3-Chloro-1-propanol >98.0%(GC) 627-30-5 25g $45 2026-04-30 Buy
TCI Chemical C0270 3-Chloro-1-propanol >98.0%(GC) 627-30-5 100g $104 2026-04-30 Buy
Usbiological 269401 3-Chloro-1-propanol, contains 0. Asreported 627-30-5 100g $392 2026-06-03 Buy
Product number Packaging Price Buy
C46403 25g $51.3 Buy
C46403 100g $108 Buy
C0270 25g $45 Buy
C0270 100g $104 Buy
269401 100g $392 Buy

3-Chloro-1-propanol Chemical Properties,Uses,Production

Chemical Properties

Colorless to pale-yellow liquid; characteristic odor. Soluble in water, alcohols, and ethers; insoluble in hydrocarbons. Combustible.

Uses

3-Chloro-1-propanol is used in organicsynthesis to produce cyclopropane andtrimethylene oxide. It is an intermediate inthe synthesis of pharmaceuticals, agrochemicals, antiseptic agents, and dyes. It is an inhibitor of triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase.

Preparation

3-Chloro-1-propanol is synthesized by the reaction of 1, 3-propanediol and hydrochloric acid, using benzene sulfonic acid as the catalyst.
Reaction: 250 g of trimethylene glycol are shaken with 450 g of sulfur chloride, the mixture becoming warm, sulfur dioxide being rapidly evolved, and sulfur deposited. This reaction continues for 1 hours without heating, whereafter the mixture is heated for a further 6 hours on the water-bath and then for 30 min, over a free flame. When no more sulfur dioxide is evolved, the mixture is allowed to cool, then extracted several times with ether. The sulfur is washed with ether, and the united ethereal layers are shaken with sodium carbonate solution to remove sulfur dioxide, dried over sodium sulfate, and freed from ether. The residue is fractionated and the fraction of b.p. 140-180° C is redistilled, giving 60% (160 g) of 3-chloro-1-propanol, b.p. 160-164°C/760 mm, 60-64° C/10 mm.
J. Amer. Chem. Soc, 38, 2481 (1916)
J. Chem. Soc, 1928, 2439

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 2927, 1968 DOI: 10.1021/ja01013a033
The Journal of Organic Chemistry, 55, p. 2968, 1990 DOI: 10.1021/jo00296a078
Organic Syntheses, Coll. Vol. 1, p. 533, 1941

General Description

3-Chloro-1-propanol appears as a colorless liquid with a mild odor. Slightly denser than water. Toxic by ingestion and inhalation . Flash point 270°F. Used to make plastics, resins and other chemicals.

Reactivity Profile

3-Chloro-1-propanol may be sensitive to prolonged exposure to light. 3-Chloro-1-propanol may react with oxidizing agents. .

Health Hazard

3-Chloro-1-propanol also know as Trimethylene chlorohydrin, is a moderatelytoxic compound. Skin contact can cause irritation.Ingestion can result in CNSdepression, muscle contraction, gastrointesti nal pain, and ulceration or stomach bleed ing. High dosage can cause liver injury. Thetoxicity of this compound, however, is lesssevere than that of its isomer, propylene β-chlorohydrin.
LD50 value, oral (mice): 2300 mg/kg

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Moderately toxic by ingestion. Mutation data reported. Chloropropanols have mutagenic and carcinogenic properties. The 3-monochloropropanol (3-MCPD) is the main chloropropanol found in hydrolyzates of vegetable protein (HVP) made by acid hydrolysis.

Toxics Screening Level

The ITSL for 3-chloro-1-propanol has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

Waste Disposal

Trimethylene chlorohydrin is burned in achemical incinerator equipped with an afterburner and scrubber.

3-Chloro-1-propanol synthesis

504-63-2
627-30-5
Synthesis of 3-Chloro-1-propanol from 1,3-Propanediol

3-Chloro-1-propanol Preparation Products And Raw materials

Raw materials

Preparation Products

9-(3-(cis-3 5-Dimethyl-1-piperazinyl)- 3-Chloropropionic acid 1,5-Diazabicyclo[4.3.0]non-5-ene Mivacurium chloride 4-(3-Morpholinopropoxy)-3,5-dichlorobenzenamine
Propylene carbonate 9-Vinylanthracene Trimethylene oxide Glycidyl methyl ether 3-Chloropropyl acetate
1-Chloro-2-propanol 1-Chloro-3-(tolene-p-sulphonyloxy) propane 3-(3-Hydroxy-propylamino)-propan-1-ol 3-Iodopropan-1-ol 1-(3-Hydroxypropyl)-4-methylpiperazine
3-Fluoropropan-1-ol 3-Phenoxy-1-propanol 1-(3-Hydroxypropyl)-1H-imidazole Propylene glycol n-butyl ether 3-(2-methyl-1H-imidazol-1-yl)propan-1-ol(SALTDATA: HCl)

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3-Chloro-1-propanol Suppliers

Global( 395)Suppliers
Supplier Tel Email Country ProdList Advantage
Zouping Mingxing Chemical Co.,Ltd 18806491188 lzkysong@163.com China 20 58
Tongling LishidaChem Technology Co., Ltd 19064063435 18606623089 2236291497@qq.com China 182 58
Zouping Mingxing Chemical Co.,Ltd. 86-13605431940 13605431940 zpmxchemical@126.com China 1490 62
nantong honglong 13078814179 13078814179 2771867773@qq.com China 961 58
Chizhou Bluesky Chemical Co., Ltd. 15996451730; 15996451730 719225026@qq.com China 39 58
ZOUPING MINGYUAN IMP.&EXP. TRADE CO.,LTD. 18364991597 fox793@163.com China 21 58
Shanghai Qiji Yongying Biotechnology Co., Ltd. 13069481218 chen274650335@126.com China 336 58
Yangzhou Princechem Co.,Ltd 18921928333 david@princechem.com China 498 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Supplier Advantage
Zouping Mingxing Chemical Co.,Ltd 58
Tongling LishidaChem Technology Co., Ltd 58
Zouping Mingxing Chemical Co.,Ltd. 62
nantong honglong 58
Chizhou Bluesky Chemical Co., Ltd. 58
ZOUPING MINGYUAN IMP.&EXP. TRADE CO.,LTD. 58
Shanghai Qiji Yongying Biotechnology Co., Ltd. 58
Yangzhou Princechem Co.,Ltd 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69

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View Lastest Price from 3-Chloro-1-propanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-1-propanol pictures 2026-05-28 3-Chloro-1-propanol
627-30-5
 $10.00 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
3-Chloro-1-propanol pictures 2026-05-15 3-Chloro-1-propanol
627-30-5
 $1.50 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
3-Chloro-1-propanol pictures 2025-08-05 3-Chloro-1-propanol
627-30-5
 1kg 99% 10 tons Zouping mingyuan import & export trading co., ltd

3-Chloro-1-propanol Spectrum

3-Chloro-1-propanol(627-30-5)MS3-Chloro-1-propanol(627-30-5)1HNMR3-Chloro-1-propanol(627-30-5)13CNMR3-Chloro-1-propanol(627-30-5)IR13-Chloro-1-propanol(627-30-5)Raman

627-30-5(3-Chloro-1-propanol)Related Search:

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TRIMETHYLENE CHLOROHYDRIN 1-Chloro-3-propanol 3-Chloro-1-hydroxypropane 3-chloro-1-propano 3-Chloropropane-1-ol 3-Chlorpropan-1-ol Propanol, 3-chloro- LABOTEST-BB LT01690209 3-CHLORO-1-PROPANOL 1-CHLORO-3-HYDROXYPROPANE, 3-CHLORO-1-PROPANOL, TRIMETHYLENE CHLOROHYDRIN Chloro-1-propanol 3-Chloro-1-propanol,98+% 3-Chloro-1-propyl alcohol 1-Chloro-3-hydroxypropane, stabilized, 98% Chloropropanol,98% oro-1-propanoL 1-Propanol, 3-chloro- 3-CHLORO-1-PROPANOL / 1-CHLORO-3-HYDROXYPROPANE 1-Chloro-3-hydroxypropane, stabilized, 98% 100GR 1-Chloro-3-hydroxypropane, stabilized, 98% 25GR 1-Chloro-3-hydroxypropane, 98%, stabilized 3-Chloropropyl alcohol NSC 60190 3-CHLORO-1-PROPANOL FOR SYNTHESIS 1-Chloro-3-hydroxypropane, Trimethylene chlorohydrin Chloro-1-propa 3-chloro-1-propanol, 3-chloro-propanol 3-chloro-1-propane 3-CHLORPROPANOL 3-Chloro-1-propanol> Fudosteine Intermediate Fudosteine Impurity C 3-chlorine-1-propyl alcohol 3-Chloro-1-propanol, ≥ 98.0% 1-Chloro-3-propanol in methanol 3-Chloropropanol-1 1-CHLORO-3-HYDROXYPROPANE 3-Chloropropanol 3-CHLOROPROPAN-1-OL 627-30-5 627-30-6 ClCH2CH2CH2OH ClCH23OH Oxygen Compounds Organic Building Blocks Building Blocks Alcohols C2 to C6 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides 蠅-Chloroalkanols Cyclomethycaine Piperocaine omega-Chloroalkanols omega-Functional Alkanols, Carboxylic Acids, Amines & Halides Alcohols Building Blocks C2 to C6 Chemical Synthesis