15-Lipoxygenase Inhibitor 1
- CAS No.
- 928853-86-5
- Chemical Name:
- 15-Lipoxygenase Inhibitor 1
- Synonyms
- 4-MMPB;4-MMPB, 10 mM in DMSO;15-Lipoxygenast Inhibitorl;15-Lipoxygenase Inhibitor I;15-Lipoxygenase Inhibitor 1;15-Lipoxygenase Inhibitor 1(4-MMPB);15-Lipoxygenase Inhibitor 1 Exclusive;15-Lipoxygenase Inhibitor 1 (15-LO Inhibitor 1);4-Methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine;4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine
- CBNumber:
- CB02589916
- Molecular Formula:
- C16H19N5S
- Molecular Weight:
- 313.42
- MDL Number:
- MOL File:
- 928853-86-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
15-Lipoxygenase Inhibitor 1 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010468 | 15-Lipoxygenase Inhibitor 1 ≥95% | 928853-86-5 | 500μg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 10010468 | 15-Lipoxygenase Inhibitor 1 ≥95% | 928853-86-5 | 1mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 10010468 | 15-Lipoxygenase Inhibitor 1 ≥95% | 928853-86-5 | 5mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 10010468 | 15-Lipoxygenase Inhibitor 1 ≥95% | 928853-86-5 | 10mg | $469 | 2026-04-30 | Buy |
| Biosynth | DMB85386 | 4-Methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine | 928853-86-5 | 1mg | $250 | 2026-06-04 | Buy |
15-Lipoxygenase Inhibitor 1 Chemical Properties, Uses, Production
Uses
4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer[1][2][3][4].
Biological Activity
4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with IC50 value of 18 μM. The IC50 values of it against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1) were 19.5 μM and 19.1 μM, respectively. It has potential for prostate cancer research.
in vitro
4-MMPB has an IC 50 of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay
| Cell Line: | DU145 cells, PC-3 cells, HFF3 cells |
| Concentration: | 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells. |
target
IC50: 18 μM (15-lipoxygenase)
References
[1] M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6. DOI:10.1016/j.bmc.2006.12.022
[2] Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.
[3] Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132. DOI:10.1111/cbdd.13174
[4] Saffiyeh Saboormaleki, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition. Arch Iran Med. 2018 Jun 1;21(6):251-259. PMID:29940744
15-Lipoxygenase Inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
15-Lipoxygenase Inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4183 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
