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PF4455242 hydrochloride

PF4455242 hydrochloride Structure
PF4455242 hydrochloride structure
CAS No.
1322001-35-3
Chemical Name:
PF4455242 hydrochloride
Synonyms
PF-4455242-HCl;PF 4455242,PF4455242;PF4455242 hydrochloride;PF-4455242 hydrochloride;PF04455242 hydrochloride;PF 4455242 hydrochloride;PF 04455242 hydrochloride;PF-04455242 (hydrochloride);PF-04455242 hydrochloride >=98% (HPLC);2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)propan-1-amine
CBNumber:
CB02667430
Molecular Formula:
C21H29ClN2O2S
Molecular Weight:
408.99
MDL Number:
MFCD22666388
MOL File:
1322001-35-3.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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PF4455242 hydrochloride Properties

storage temp. room temp
solubility DMSO: soluble5mg/mL (clear solution, warmed)
form powder
color white to beige
InChI 1S/C21H28N2O2S.ClH/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23;/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3;1H
InChIKey WRNZYMZEVIVCFL-UHFFFAOYSA-N
SMILES Cl.CC(C)CNCc1ccc(cc1)-c2ccccc2S(=O)(=O)N3CCCC3
FDA UNII W2XT1FW9V4
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

PF4455242 hydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0206 PF-04455242 hydrochloride ≥98% (HPLC) 1322001-35-3 5mg $129 2024-03-01 Buy
Sigma-Aldrich PZ0206 PF-04455242 hydrochloride ≥98% (HPLC) 1322001-35-3 25mg $505 2024-03-01 Buy
Biosynth XCC00135 Pf-04455242 hydrochloride 1322001-35-3 50mg $1199 2026-06-05 Buy
ChemScene CS-0008399 PF-4455242 hydrochloride ≥98% 1322001-35-3 1mg $589 2026-06-04 Buy
ChemScene CS-0008399 PF-4455242 hydrochloride ≥98% 1322001-35-3 5mg $1466 2026-06-04 Buy
Product number Packaging Price Buy
PZ0206 5mg $129 Buy
PZ0206 25mg $505 Buy
XCC00135 50mg $1199 Buy
CS-0008399 1mg $589 Buy
CS-0008399 5mg $1466 Buy

PF4455242 hydrochloride Chemical Properties, Uses, Production

Uses

PF-4455242 hydrochloride is a selective, short-acting antagonist of the κ-opioid receptor, exhibiting potential analgesic effects. PF-4455242 hydrochloride has been identified through a strategy utilizing parallel chemistry and physicochemical property design. PF-4455242 hydrochloride demonstrated confirmed potency and selectivity in the tail-flick analgesia model.

Biological Activity

PF-4455242 is a selective k opioid receptor (KOR) antagonist with 20-fold selectivity for kappa over mu receptors (k Ki = 3 nM, μ Ki =64 nM). PF-4455242 is orally active, has good brain penetration in rats and was able to block the effects of the kappa agonist U50488. Studies indicate th at k blockade has afforded antidepressant activity in several animal models. PF-4455242 has been in phase I clinical trials for trial for bipolar depression.

References

[1] Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242)

PF4455242 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

PF4455242 hydrochloride Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
AstaTech (Chengdu) Pharma. Co., Ltd. 15928766785 15928766785 wupengcheng@astatech.cn China 1997 55
Shanghai Tombiopharma Chemical Co. Ltd. 13391076197 tombiopharma@163.com China 4986 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9389 58
AFINE CHEMICALS LIMITED +86-571-85134551 +86-18958018566 info@afinechem.com China 15030 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Jingmo (Xiamen) Biotechnology Co., Ltd 13621943973; 13621943973 sales@jamxmpharmatech.com China 1191 58
career henan chemical co +86-0371-86658258 factory@coreychem.com China 29780 58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo 18584079237 312074905@qq.com China 2523 58
Supplier Advantage
AstaTech (Chengdu) Pharma. Co., Ltd. 55
Shanghai Tombiopharma Chemical Co. Ltd. 55
SPIRO PHARMA 55
TargetMol Chemicals Inc. 58
Baoji Guokang Healthchem co.,ltd 58
AFINE CHEMICALS LIMITED 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
Jingmo (Xiamen) Biotechnology Co., Ltd 58
career henan chemical co 58
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo 58

View Latest Price from PF4455242 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-4455242 HCl pictures 2026-05-11 PF-4455242 HCl
1322001-35-3
 $1520.00-2500.00 99.59% 10g TargetMol Chemicals Inc.
PF4455242 hydrochloride pictures 2019-12-24 PF4455242 hydrochloride
1322001-35-3
 $1.00 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • PF-4455242 HCl pictures
  • PF-4455242 HCl
    1322001-35-3
  • $1520.00-2500.00
  • 99.59%
  • TargetMol Chemicals Inc.

PF4455242 hydrochloride Spectrum

PF4455242 hydrochloride(1322001-35-3)1HNMR

1322001-35-3 (PF4455242 hydrochloride) Related Search:

Benzenesulfonamide, 2,5-dimethyl-N-[[2-(1-piperidinylsulfonyl)phenyl]methyl]- 4-Methyl-3-(piperidine-1-sulfonyl)-phenylamine N-tert-butyl-4'-((4-MethylbenzylaMino)Methyl)biphenyl-2-sulfonaMide PF4455242 hydrochloride [4-(pyrrolidine-1-sulfonyl)phenyl]methanamine hydrochloride
1-((4-Bromo-2-ethylphenyl)sulfonyl)pyrrolidine

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PF 04455242 hydrochloride PF 4455242 hydrochloride PF-04455242 (hydrochloride) PF04455242 hydrochloride PF4455242 hydrochloride PF-4455242 hydrochloride 2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine hydrochloride N-(2-Methylpropyl)-2′-(1-pyrrolidinylsulfonyl)-[1,1′-biphenyl]-4-methanamine hydrochloride 2-METHYL-N-((2'-(PYRROLIDIN-1-YLSULFONYL)-[1,1'-BIPHENYL]-4-YL)METHYL)PROPAN-1-AMINE HCL 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)propan-1-amine PF-04455242 hydrochloride >=98% (HPLC) PF 4455242,PF4455242 PF-4455242-HCl 2-Methyl-N-[[2'-(1-pyrrolidinylsulfonyl)-4-biphenylyl]methyl]-1-propanamine Hydrochloride 1322001-35-3 C21H29ClN2O2S