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ChemicalBook >> CAS DataBase List >>5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Structure
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde structure
CAS No.
881677-11-8
Chemical Name:
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Synonyms
5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde;Vonoprazan N -1;5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity);Vonoprazan-10;Vonoprazan-026;TAK438 Impurity 67;Vonolazan impurity 12;TAK438 Intermediate 5;Vonolarazan impurity 12
CBNumber:
CB02680972
Molecular Formula:
C16H11FN2O3S
Molecular Weight:
330.33
MDL Number:
MFCD11875978
MOL File:
881677-11-8.mol
MSDS File:
SDS
Last updated:2026-06-26 14:34:25
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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Properties

Boiling point 563.7±60.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly)
pka -0.34±0.11(Predicted)
form Solid
color Pale Brown to Light Brown
InChI InChI=1S/C16H11FN2O3S/c17-15-6-2-1-5-14(15)16-8-12(11-20)10-19(16)23(21,22)13-4-3-7-18-9-13/h1-11H
InChIKey IXCSYEVJOAWXRH-UHFFFAOYSA-N
SMILES N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(C=O)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
REACH Registrations Active

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 425343 3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde 881677-11-8 100mg $355 2026-06-03 Buy
Usbiological 425343 3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde 881677-11-8 250mg $509 2026-06-03 Buy
Biosynth FF99563 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde 881677-11-8 10g $900 2026-06-04 Buy
Biosynth FF99563 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde 881677-11-8 2g $900 2026-06-04 Buy
Biosynth FF99563 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde 881677-11-8 25g $900 2026-06-04 Buy
Product number Packaging Price Buy
425343 100mg $355 Buy
425343 250mg $509 Buy
FF99563 10g $900 Buy
FF99563 2g $900 Buy
FF99563 25g $900 Buy

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Chemical Properties, Uses, Production

Chemical Properties

Pale Brown to Light Brown Solid.

Uses

3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde is an impurity of Vonaprazan (V767010) a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

Synthesis

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde is prepared by the reaction of 3-pyridinesulfonyl Chloride and 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde. The specific synthesis steps are as follows:
Take 10.0g (52.86mmol) of compound, 5.9g (58.15mmol) of triethylamine and 100mL of dichloromethane, cool the system to 0°C, add dropwise a dichloromethane solution (100mL) of compound G (58.15mmol), and add dropwise After completion, the system was reacted at room temperature for 6 hours, 100mL of water was added and washed twice, the organic phase was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 16.4g of 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde, with a yield of 93.8%.
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde synthesis

Solubility in organics

Chloroform (Slightly), DMSO (Slightly)

References

[1] Patent: CN106478601, 2017, A. Location in patent: Paragraph 0036; 0037
[2] Patent: EP2963019, 2016, A1. Location in patent: Paragraph 0142; 0146
[3] Patent: CN107586288, 2018, A. Location in patent: Paragraph 0035-0037
[4] Patent: US2018/186736, 2018, A1. Location in patent: Paragraph 0142; 0143
[5] Patent: US2011/306769, 2011, A1. Location in patent: Page/Page column 28-29

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

pyridine-3-sulfonyl chloride 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Pyridine-3-sulfonyl chloride hydrochloride Triethylamine Acetonitrile
4-Dimethylaminopyridine

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Preparation Products

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Suppliers

Global Suppliers ( 282)
Supplier Tel Email Country ProdList Advantage
Shandong Chuangye Pharmaceutical Technology Co., Ltd. 13325129676 3610186177@qq.com China 22 58
CHENGHUI PHARMACEUTICAL GROUP LTD 053158897070 15550412551 market@jnchsd.com China 241 58
Shandong Xuande Pharmaceutical Technology Co. LTD 18866895588 dingjiaying@shiningpharm.com China 184 55
Ningbo Zhenlei Chemical Co.,ltd. 0576-88503603 15925898989 wlh@zhenleichem.com China 126 58
Lianyungang Shenghe Biotechnology Co., Ltd. 0518-87108777 13585296001 haizaofu@163.com China 44 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 0755-83725350 13380397412 3001280422@qq.com China 10000 58
Jinan Sanyuan Chemical Co. LTD 18615587029 3382711390@qq.com China 333 58
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd 13801189771 13801208576 maggie@chinazhongshuo.com China 88 65
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Shandong Chuangye Pharmaceutical Technology Co., Ltd. 58
CHENGHUI PHARMACEUTICAL GROUP LTD 58
Shandong Xuande Pharmaceutical Technology Co. LTD 55
Ningbo Zhenlei Chemical Co.,ltd. 58
Lianyungang Shenghe Biotechnology Co., Ltd. 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 58
Jinan Sanyuan Chemical Co. LTD 58
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd 65
ChemFuture PharmaTech (Jiangsu) Ltd 65
Adamas Reagent, Ltd. 59

View Latest Price from 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole pictures 2026-09-02 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole
881677-11-8
 $1.00-8.00 1KG 99% Henan Fengda Chemical Co., Ltd
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- pictures 2026-08-25 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
881677-11-8
 $80.00-800.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- pictures 2026-08-25 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-
881677-11-8
 $80.00-800.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Spectrum

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde(881677-11-8)1HNMR5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde(881677-11-8)1HNMR

881677-11-8 (5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde) Related Search:

(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 5-chloropyridine-3-sulfonyl chloride Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol
4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene N-(1-(naphthalen-1-yl)ethyl)forMaMide 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl-
1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- Pyridine-2-sulfonyl chloride 3-Pyridinesulfonic acid 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile
Vonoprazan 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-Pyrrole-3-methanol, 5-(2-fluorophenyl)-

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5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldenhyde 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde TAK-438( Vonoprazan fumarate) intermediate 4 (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Vonoprazan-026 TAK438 Impurity 67 Vonoprazan impurity 31/5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3- carbaldehyde Vonoprazan N -1 Vonoprazan-10 2-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)acetaldehyde 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3- 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity) 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carb... 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbaldehyde TAK438 Intermediate 5 5- (2-Fluorophenyl)-1- (pyridine-3-sulphonyl)-1-H-pyrrole-3-carbaldehyde Vonolazan impurity 12 5-(2-Fluoropheny1)-1-[( pyridin -3- yl ) sulfonyl ]-1H- pyrrole -3- carboxaldehyde 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carba Sulfonyl aldehyde Impurity of Vonoprazan 5-(2-FluorophenyI)-1-[(py ridin-3-yl)sulfonyl]-1H-p yrrole-3-carboxaldehyde 5-(2-Fluorophenyl)-1-(3-pyridylsulfonyl)pyrrole-3-carbaldehyde 4-Des-(N-Methyl)aminomethyl Vonoprazan-4-carboxaldehyde 2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde">5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Vonolarazan impurity 12 Fumaric Acid Voronolaprazole 14 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde 5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrole-3-carbaldehyde 881677-11-8 881674-11-8 881677-11-8