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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde structure

CAS No.: 881677-11-8

Chemical Name:: 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

Synonyms: 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde;Vonoprazan N -1;5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity);Vonoprazan-10;Vonoprazan-026;TAK438 Impurity 67;Vonolazan impurity 12;TAK438 Intermediate 5;Sulfonyl aldehyde Impurity of Vonoprazan

CBNumber:: CB02680972

Molecular Formula:: C16H11FN2O3S

Molecular Weight:: 330.33

MDL Number:: MFCD11875978

MOL File:: 881677-11-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:12:02

Product description	Number	Pack Size	Price
3-Des-N-methylmethanamineVonoprazan-3-carbaldehyde	D294328	500mg	$255
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde	2733EA	5g	$658
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 97%	CD11035613	5g	$420
5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 97%	CM176209	5g	$533
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde	881677118	5g	$604.2
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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Properties

Boiling point	563.7±60.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
pka	-0.34±0.11(Predicted)
color	Pale Brown to Light Brown
InChI	InChI=1S/C16H11FN2O3S/c17-15-6-2-1-5-14(15)16-8-12(11-20)10-19(16)23(21,22)13-4-3-7-18-9-13/h1-11H
InChIKey	IXCSYEVJOAWXRH-UHFFFAOYSA-N
SMILES	N1(S(C2=CC=CN=C2)(=O)=O)C(C2=CC=CC=C2F)=CC(C=O)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D294328	3-Des-N-methylmethanamineVonoprazan-3-carbaldehyde	881677-11-8	500mg	$255	2021-12-16	Buy
AK Scientific	2733EA	5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde	881677-11-8	5g	$658	2021-12-16	Buy
Crysdot	CD11035613	5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 97%	881677-11-8	5g	$420	2021-12-16	Buy
Chemenu	CM176209	5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 97%	881677-11-8	5g	$533	2021-12-16	Buy
Alichem	881677118	5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde	881677-11-8	5g	$604.2	2021-12-16	Buy

Product number	Packaging	Price	Buy
D294328	500mg	$255	Buy
2733EA	5g	$658	Buy
CD11035613	5g	$420	Buy
CM176209	5g	$533	Buy
881677118	5g	$604.2	Buy

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Uses,Production

Chemical Properties

Pale Brown to Light Brown Solid.

Uses

3-Des-N-methylmethanamine Vonoprazan-3-carbaldehyde is an impurity of Vonaprazan (V767010) a novel potassium-competitive acid blocker for the treatment of acid-related diseases.

Synthesis

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde is prepared by the reaction of 3-pyridinesulfonyl Chloride and 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde. The specific synthesis steps are as follows:
Take 10.0g (52.86mmol) of compound, 5.9g (58.15mmol) of triethylamine and 100mL of dichloromethane, cool the system to 0°C, add dropwise a dichloromethane solution (100mL) of compound G (58.15mmol), and add dropwise After completion, the system was reacted at room temperature for 6 hours, 100mL of water was added and washed twice, the organic phase was dried with anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 16.4g of 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde, with a yield of 93.8%.

Solubility in organics

Chloroform (Slightly), DMSO (Slightly)

References

[1] Patent: CN106478601, 2017, A. Location in patent: Paragraph 0036; 0037
[2] Patent: EP2963019, 2016, A1. Location in patent: Paragraph 0142; 0146
[3] Patent: CN107586288, 2018, A. Location in patent: Paragraph 0035-0037
[4] Patent: US2018/186736, 2018, A1. Location in patent: Paragraph 0142; 0143
[5] Patent: US2011/306769, 2011, A1. Location in patent: Page/Page column 28-29

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

pyridine-3-sulfonyl chloride 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Pyridine-3-sulfonyl chloride hydrochloride Triethylamine Acetonitrile

4-Dimethylaminopyridine

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Preparation Products

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Suppliers

Global( 271)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Hebei Dangtong Import and export Co LTD	+86-86-4001020630 +8619831957301	admin@hbdangtong.com	China	1000	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8749	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8495	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580	da@zhongda-biotech.com	China	232	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	286	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	193	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Hebei Dangtong Import and export Co LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Firsky International Trade (Wuhan) Co., Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shandong Huisheng Import & Export Co., Ltd.	58
Anhui Zhongda Biotechnology Co., Ltd	58
Anhui Zhongda Biotechnology Co., Ltd	58

View Lastest Price from 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-06	5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 881677-11-8	US $20.00 / kg	1kg	99	100000	Hebei Chuanghai Biotechnology Co., Ltd
2026-02-25	881677-11-8 881677-11-8	US $300.00-250.00 / kg	100kg	99.99%	100Tons	Hebei Dangtong Import and export Co LTD
2026-02-05	5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde 881677-11-8	US $0.00 / KG Ton	1KG Ton	99%+	2 tons/month	ZHUHAI HRD PHARMACEUTICAL CO., LTD.

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
881677-11-8
US $20.00 / kg
99
Hebei Chuanghai Biotechnology Co., Ltd

881677-11-8
881677-11-8
US $300.00-250.00 / kg
99.99%
Hebei Dangtong Import and export Co LTD

5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde
881677-11-8
US $0.00 / KG Ton
99%+
ZHUHAI HRD PHARMACEUTICAL CO., LTD.

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Spectrum

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde(881677-11-8)¹HNMR 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde(881677-11-8)¹HNMR

881677-11-8(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde)Related Search:

(Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 5-chloropyridine-3-sulfonyl chloride Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol

4-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene N-(1-(naphthalen-1-yl)ethyl)forMaMide PYRIDINE-2-SULFONYL CHLORIDE 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester

1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 3-Pyridinesulfonic acid 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)-

2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile Vonoprazan 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile

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5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrole-3-carboxaldehyde 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldenhyde 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carboxaldehyde TAK-438( Vonoprazan fumarate) intermediate 4 (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Vonoprazan-026 TAK438 Impurity 67 Vonoprazan impurity 31/5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3- carbaldehyde Vonoprazan N -1 Vonoprazan-10 2-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)acetaldehyde 5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3- 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (Vonoprazan Impurity) 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-Pyrrole-3-carb... 5-(2-Fluorophenyl)-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-carbaldehyde TAK438 Intermediate 5 5- (2-Fluorophenyl)-1- (pyridine-3-sulphonyl)-1-H-pyrrole-3-carbaldehyde Vonolazan impurity 12 5-(2-Fluoropheny1)-1-[( pyridin -3- yl ) sulfonyl ]-1H- pyrrole -3- carboxaldehyde 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carba Sulfonyl aldehyde Impurity of Vonoprazan 5-(2-FluorophenyI)-1-[(py ridin-3-yl)sulfonyl]-1H-p yrrole-3-carboxaldehyde 5-(2-Fluorophenyl)-1-(3-pyridylsulfonyl)pyrrole-3-carbaldehyde 4-Des-(N-Methyl)aminomethyl Vonoprazan-4-carboxaldehyde 2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde">5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 881677-11-8 881674-11-8 881677-11-8