pyridine-3-sulfonyl chloride
- CAS No.
- 16133-25-8
- Chemical Name:
- pyridine-3-sulfonyl chloride
- Synonyms
- 3-Pyridine sulphonyl chloride;m-Pyridinesulfonyl chloride;3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE;PYRIDINE-3-SULPHONYL CHLORIDE HYDROCHLORIDE;Vonoprazan-8;Vonoprazan-029;TAK438 Impurity 68;Vonolazan impurity 8;Vonorazan Impurity 66;Vonoprazan Impurity 50
- CBNumber:
- CB5153121
- Molecular Formula:
- C5H4ClNO2S
- Molecular Weight:
- 177.61
- MDL Number:
- MFCD04035552
- MOL File:
- 16133-25-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 144 °C |
|---|---|
| Boiling point | 284℃ |
| Density | 1.488 |
| refractive index | n20/D 1.556 |
| Flash point | 126℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | liquid |
| pka | -1.77±0.11(Predicted) |
| color | Colourless to light yellow |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H |
| InChIKey | CDRNYKLYADJTMN-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1S(Cl)(=O)=O |
| LogP | 1.75 |
| CAS DataBase Reference | 16133-25-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05, GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H317 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Hazard Codes | Xi,C |
| Risk Statements | 34-43 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | 3261 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B Skin Sens. 1 |
| REACH Registrations | Active |
pyridine-3-sulfonyl chloride price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS013908 | 3-pyridinesulfonyl chloride hydrochloride Aldrich | 16133-25-8 | 250mg | $136 | 2026-04-30 | Buy |
| Sigma-Aldrich | 749273 | Pyridine-3-sulfonyl chloride 95% | 1G | $55.4 | 2026-04-30 | Buy | |
| AstaTech | 65426 | PYRIDINE-3-SULFONYL CHLORIDE 97% | 16133-25-8 | 1G | $7 | 2026-04-30 | Buy |
| AstaTech | 65426 | PYRIDINE-3-SULFONYL CHLORIDE 97% | 16133-25-8 | 5G | $9 | 2026-04-30 | Buy |
| AstaTech | 65426 | PYRIDINE-3-SULFONYL CHLORIDE 97% | 16133-25-8 | 25G | $19 | 2026-04-30 | Buy |
pyridine-3-sulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
It is a colorless, transparent liquid. It is extremely unstable when in contact with water and is easily hydrolyzed to generate pyridine-3-sulfonic acid and hydrochloric acid, which makes it lose its reactivity.
Uses
3-pyridinesulfonyl Chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Application
Pyridine-3-sulfonyl chloride is an essential medical intermediate and is widely applied to the synthesis of medicines, wherein the pyridine-3-sulfonyl chloride is mainly used for preparing TAK-438 (vonoprazan fumarate), which is a novel orally active potassium-competitive acid blocker, developed as an antisecretory drug.
Toxicology
Pyridine-3-sulfonyl chloride causes burns of eyes, skin and mucous membranes. Contact with water liberates toxic gas.
Synthesis
Add thionyl chloride to the water, cool to about 0-5°C, and add cuprous chloride. Fluoboric acid diazonium salt was added to the solution and reacted at 0-5°C overnight. The reaction solution was extracted with dichloromethane, combining the organic layers. The organic layer was washed once with saturated aqueous sodium bicarbonate solution, once with water, and finally once with saturated brine. The product was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to remove methylene chloride to obtain the product pyridine-3-sulfonyl chloride with a yield of 90.7%.
References
[1] Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4889 - 4898
[2] Patent: US2006/217387, 2006, A1. Location in patent: Page/Page column 25
[3] Journal of Medicinal Chemistry, 1999, vol. 42, # 13, p. 2409 - 2421
[4] Patent: CN106432067, 2017, A. Location in patent: Paragraph 0090
[5] Patent: WO2016/90317, 2016, A1. Location in patent: Page/Page column 73
pyridine-3-sulfonyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ningbo Zhenlei Chemical Co.,ltd. | 0576-88503603 15925898989 | wlh@zhenleichem.com | China | 126 | 58 |
| Nan Ping XuhHong Chemical Co. Ltd | 15159460808 13905998146 | kobe@xuhongchem.com | China | 33 | 58 |
| Shanghai Mixiu Chemical Co., Ltd. | 18101936766 | eileen@shmychem.com | China | 349 | 55 |
| Shandong Xuande Pharmaceutical Technology Co. LTD | 18866895588 | dingjiaying@shiningpharm.com | China | 184 | 55 |
| Shandong Chuangye Pharmaceutical Technology Co., Ltd. | 13325129676 | 3610186177@qq.com | China | 22 | 58 |
| Lianyungang Shenghe Biotechnology Co., Ltd. | 0518-87108777 13585296001 | haizaofu@163.com | China | 44 | 58 |
| Shanghai Junren Biotechnology Co., Ltd | 18217672758 | 30575863@qq.com | China | 17 | 58 |
| Nanjing ShenNiao Chemical Technology Co.,LTD | 025-86667050 17861123238 | majiaming@snscm.com | China | 247 | 58 |
| Chongqing Zhicheng Pharmaceutical Technology Co., Ltd. | 13957683608 | sales@zyscin.com | China | 60 | 58 |
| Shanghai Newthink Biotechnology Co., Ltd. | 18121861491 | 3847526528@qq.com | China | 107 | 58 |
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View Lastest Price from pyridine-3-sulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Pyridine-3-sulfonyl chloride hydrochloride
16133-25-8
|
1kg | 98%min GC | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-25 | pyridine-3-sulfonyl chloride
16133-25-8
|
$80.00-800.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-08-25 | pyridine-3-sulfonyl chloride
16133-25-8
|
$100.00-1000.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Pyridine-3-sulfonyl chloride hydrochloride
16133-25-8
- 98%min GC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- pyridine-3-sulfonyl chloride
16133-25-8
- $80.00-800.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- pyridine-3-sulfonyl chloride
16133-25-8
- $100.00-1000.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
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