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3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID structure

CAS No.: 25173-72-2

Chemical Name:: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID

Synonyms: AKOS BBS-00006959;TIMTEC-BB SBB000794;LABOTEST-BB LT00233171;5-Trimethoxyphenyl)propanoic acid;3,4,5-TRIMETHOXYHYDROCINNAMIC ACID;3,4,5-Trimethoxyphenylpropionic acid;3,4,5-trimethoxydihydrocinnamic acid;3-(3,4,5-trimethoxyphenyl)propanoate;3,4,5-Trimethoxybenzenepropanoic acid;3,4,5-Trimethoxybenzenepropionic acid

CBNumber:: CB0283225

Molecular Formula:: C12H16O5

Molecular Weight:: 240.25

MDL Number:: MFCD00002775

MOL File:: 25173-72-2.mol

MSDS File:: SDS

Last updated:2025-10-16 15:39:32

Product description	Number	Pack Size	Price
3-(3,4,5-Trimethoxyphenyl)propionic acid ≥98%	197874	25g	$300
3-(3,4,5-Trimethoxyphenyl)propanoic Acid min. 97.0 %	T4336	5G	$85
3-(3,4,5-Trimethoxyphenyl)propanoic Acid min. 97.0 %	T4336	25G	$255
3-(3,4,5-Trimethoxyphenyl)propanoicAcid	T797295	250mg	$45
3-(3,4,5-Trimethoxyphenyl)propionic acid	2721-1-51	5G	$65

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3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Properties

Melting point	100-104 °C (lit.)
Boiling point	373℃
Density	1.169
refractive index	1.5140 (estimate)
Flash point	140℃
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: 0.1 g/mL, clear
form	Crystalline Powder
pka	4.70±0.10(Predicted)
color	White to almost white
BRN	1471912
InChI	InChI=1S/C12H16O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h6-7H,4-5H2,1-3H3,(H,13,14)
InChIKey	ZCYXGVJUZBKJAI-UHFFFAOYSA-N
SMILES	C1(CCC(O)=O)=CC(OC)=C(OC)C(OC)=C1
CAS DataBase Reference	25173-72-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	36/37/38
Safety Statements	22-24/25
WGK Germany	3

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	197874	3-(3,4,5-Trimethoxyphenyl)propionic acid ≥98%	25173-72-2	25g	$300	2023-06-20	Buy
TCI Chemical	T4336	3-(3,4,5-Trimethoxyphenyl)propanoic Acid min. 97.0 %	25173-72-2	5G	$85	2025-07-31	Buy
TCI Chemical	T4336	3-(3,4,5-Trimethoxyphenyl)propanoic Acid min. 97.0 %	25173-72-2	25G	$255	2025-07-31	Buy
TRC	T797295	3-(3,4,5-Trimethoxyphenyl)propanoicAcid	25173-72-2	250mg	$45	2021-12-16	Buy
SynQuest Laboratories	2721-1-51	3-(3,4,5-Trimethoxyphenyl)propionic acid	25173-72-2	5G	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
197874	25g	$300	Buy
T4336	5G	$85	Buy
T4336	25G	$255	Buy
T797295	250mg	$45	Buy
2721-1-51	5G	$65	Buy

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Chemical Properties,Uses,Production

Chemical Properties

WHITE TO ALMOST WHITE CRYSTALLINE POWDER

Uses

3-(3,4,5-Trimethoxyphenyl)propanoic acid is found in herbs and spices. 3-(3,4,5-Trimethoxyphenyl)propanoic acid is a constituent of Piper longum (long pepper) and Piper retrofractum (Javanese long pepper).

Definition

ChEBI: A monocarboxylic acid consisting of propionic acid having a 3,4,5-trimethoxyphenyl substituent at the 3-position.

Synthesis

20329-98-0

25173-72-2

General procedure for the synthesis of 3-(3,4,5-trimethoxyphenyl)propionic acid from (E)-3-(3,4,5-trimethoxyphenyl)propenoic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, 3,4,5-trimethoxycinnamic acid (0.72 g, 0.003 mol) and PdCl2 (55 mg, 0.31 mmol) were suspended in 10% sodium hydroxide solution (6-10 mL), followed by batchwise addition of formic acid (8-12 mL). The mixture was reacted under microwave radiation for 3-5 min until the feedstock completely disappeared. Upon completion of the reaction, the cooled mixture was poured into ice water, acidified with 5% HCl and extracted with dichloromethane (3 x 10 mL). The organic layer was washed with water and dried with anhydrous Na2SO4. The solvent was removed by evaporation and the crude product was recrystallized by a solvent mixture of ethyl acetate and hexane to give 3-(3,4,5-trimethoxyphenyl)propionic acid as a white solid in 84% yield with a melting point of 102 °C (literature value 101-102 °C).1H NMR (CDCl3) δ: 6.70 (2H, s, H-2 and H-6), 3.84 (9H, s, 3-OCH3,4- OCH3 and 5-OCH3), 2.92 (2H, t, Ar-CH2-CH2-COOH), 2.70 (2H, t, -CH2-CH2-COOH); 13C NMR δ: 178.1 (COOH), 153.1 (C-3 and C-5), 135.87 (C-4 and C-1), 105.3 (C-2 and C-6) , 60.8 (4-OCH3), 56.1 (3-OCH3 and 5-OCH3), 35.5 (Ar-CH2-), 31.0 (-CH2-COOH).

IC 50

Human Endogenous Metabolite

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 11953 - 11962
[2] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[3] Patent: US2004/118673, 2004, A1. Location in patent: Page 7
[4] Bioorganic Chemistry, 2018, vol. 80, p. 408 - 421
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 30, p. 7785 - 7788

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

3,4,5-Trimethoxybenzaldehyde Palladium Malonic acid 3,4,5-TRIMETHOXYCINNAMIC ACID Sodium hydroxide

Water Formic acid

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Preparation Products

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Suppliers

Global( 114)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9644	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3767	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nextpeptide Inc	58
changzhou huayang technology co., ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-16	3-(3,4,5-Trimethoxyphenyl)propanoic acid 25173-72-2	US $29.00 / g		98.75%	10g	TargetMol Chemicals Inc.
2021-08-12	3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-08-02	me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 25173-72-2	US $1.00 / KG	1KG	95-99%	500kg/month	Career Henan Chemical Co

3-(3,4,5-Trimethoxyphenyl)propanoic acid
25173-72-2
US $29.00 / g
98.75%
TargetMol Chemicals Inc.

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
25173-72-2
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
25173-72-2
US $1.00 / KG
95-99%
Career Henan Chemical Co

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID Spectrum

3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID(25173-72-2)MS 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID(25173-72-2)¹HNMR 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID(25173-72-2)IR1 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID(25173-72-2)IR2 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID(25173-72-2)Raman

25173-72-2(3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID)Related Search:

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3-OXO-3-(2,3,4-TRIMETHOXYPHENYL)PROPIONIC ACID ETHYL ESTER Podophyllotoxin glucoside 3-AMINO-3-(3,4,5-TRIMETHOXY-PHENYL)-PROPIONIC ACID 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3,4,5-TRIMETHOXYPHENYL)-, DIETHYL ESTER 3-OXO-3-(2,3,6-TRIMETHOXYPHENYL)PROPIONIC ACID METHYL ESTER

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TIMTEC-BB SBB000794 3,4,5-TRIMETHOXYHYDROCINNAMIC ACID 3-(3,4,5-TRIMETHOXYPHENYL)PROPANOIC ACID 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID AKOS BBS-00006959 LABOTEST-BB LT00233171 BETA-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID B-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3,4,5-Trimethoxyphenylpropionic acid Benzenepropanoic acid, 3,4,5-trimethoxy- 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID , 98+% 3,4,5-trimethoxydihydrocinnamic acid 3,4,5-Trimethoxybenzenepropanoic acid 3,4,5-Trimethoxybenzenepropionic acid 3-(3,4,5-Trimethoxyphenyl)propionic acid ,99% 3,4,5-Trimethoxy-beta-phenylpropionic acid me: 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID 3-(3,4,5-trimethoxyphenyl)propanoate 5-Trimethoxyphenyl)propanoic acid 3(3,4,5Trimethoxyphenyl)propanoic acid,Endogenous Metabolite,Inhibitor,3 (3,4,5 Trimethoxyphenyl)propanoic acid,inhibit 25173-72-2 15173-72-2 CH3O3C6H2CH2CH2CO2H CARBOXYLIC ACID Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acids C11 to C12 Aromatic Propionic Acids API intermediates