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Hs 27

Hs 27 structure

CAS No.: 1562024-11-6

Chemical Name:: Hs 27

Synonyms: Hs 27;HS27,HS 27;1562024-11-7;HS27;HS-27;HS 27;HS-27, 10 mM in DMSO;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27;2-((1-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;2-((1-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27

CBNumber:: CB02984841

Molecular Formula:: C52H60N6O12S

Molecular Weight:: 993.13

MDL Number:: MFCD32173434

MOL File:: 1562024-11-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-30 11:39:11

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Hs 27 Properties

Boiling point	1095.1±75.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	-196°C
solubility	DMSO: 125 mg/mL (125.86 mM)
pka	9.33±0.20(Predicted)
form	Solid
color	Yellow to orange

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Hs 27 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0114853	HS-27 98.48%	1562024-11-6	5mg	$298	2026-06-04	Buy
ChemScene	CS-0114853	HS-27 98.48%	1562024-11-6	10mg	$477	2026-06-04	Buy
ChemScene	CS-0114853	HS-27 98.48%	1562024-11-6	25mg	$845	2026-06-04	Buy
ChemScene	CS-0114853	HS-27 98.48%	1562024-11-6	50mg	$1170	2026-06-04	Buy
ChemScene	CS-0114853	HS-27 98.48%	1562024-11-6	100mg	$1603	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0114853	5mg	$298	Buy
CS-0114853	10mg	$477	Buy
CS-0114853	25mg	$845	Buy
CS-0114853	50mg	$1170	Buy
CS-0114853	100mg	$1603	Buy

Hs 27 Chemical Properties,Uses,Production

Uses

HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1].

Biological Activity

HS-27, a fluorescent Hsp90 inhibitor, detects Hsp90 expression on the surface of intact tissue specimens. It consists of the core elements of SNX-5422, an Hsp90 inhibitor linked via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC) that binds to peripherally expressed Hsp90 combine.

in vitro

HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized.

target

HSP90

IC 50

HSP90

References

[1] Crouch BT, et al. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Sci Rep. 2019 Mar 5;9(1):3461. DOI:10.1038/s41598-019-40252-y

Hs 27 Preparation Products And Raw materials

Raw materials

Preparation Products

Hs 27 Suppliers

Global( 44)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2970	58
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Zhengzhou Huiju Chemical Co., Ltd.	0371-55900031 18137872243	3927209986@qq.com	China	9996	55
Heze Development Zone chuangli Chemical Co., Ltd.	0530-+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	849	55
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.	029-88380327 17691182729	1053@dideu.com	China	2001	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2240	58

Supplier	Advantage
BOC Sciences	65
Bide Pharmatech Ltd.	60
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Rechem science Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Zhengzhou Huiju Chemical Co., Ltd.	55
Heze Development Zone chuangli Chemical Co., Ltd.	55
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.	58
TargetMol Chemicals Inc.	58
Xi'an MC Biotech, Co., Ltd.	58

View Lastest Price from Hs 27 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-30	HS-27 1562024-11-6	$92.00-363.00		98.56%	10g	TargetMol Chemicals Inc.

HS-27
1562024-11-6
$92.00-363.00
98.56%
TargetMol Chemicals Inc.

Hs 27 Spectrum

Hs 27(1562024-11-6)¹HNMR

1562024-11-6(Hs 27)Related Search:

Hs 27 Ganetespib Gamitrinib TPP hexafluorophosphate Anti-Aging Compound Library Anti-cancer compound library

Luminespib

1of2

Hs 27 HS27;HS-27;HS 27 Benzamide, 2-[[21-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-21-thioxo-4,7,10,13,16-pentaoxa-20-azaheneicos-1-yl]amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)- 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27 1562024-11-7 HS27,HS 27 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27 2-((1-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide HS-27, 10 mM in DMSO 2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27 2-((1-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide 1562024-11-6 C52H60N6O12S