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ChemicalBook >> CAS DataBase List >>N-Boc-1-[4-spiro-piperidine]-3-indanone

N-Boc-1-[4-spiro-piperidine]-3-indanone

N-Boc-1-[4-spiro-piperidine]-3-indanone Structure
N-Boc-1-[4-spiro-piperidine]-3-indanone structure
CAS No.
159634-59-0
Chemical Name:
N-Boc-1-[4-spiro-piperidine]-3-indanone
Synonyms
tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate;Caboxylate;N-Boc-1-[4-spiro-piperidine]-3-indanone;1’-Boc-3-oxo-2,3-dihydrospiro[indene-1,4’-piperidine;1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine];tert-butyl 3-oxospiro[2H-indene-1,4'-piperidine]-1'-carboxylate;tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidin...;tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car;tert-Butyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate
CBNumber:
CB0308700
Molecular Formula:
C18H23NO3
Molecular Weight:
301.38
MDL Number:
MFCD03701251
MOL File:
159634-59-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:06
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N-Boc-1-[4-spiro-piperidine]-3-indanone Properties

Melting point 120-122 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boiling point 439.8±45.0 °C(Predicted)
Density 1.17
storage temp. Sealed in dry,Store in freezer, under -20°C
pka -0.80±0.20(Predicted)
Appearance White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P302+P352-P305+P351+P338
HazardClass  IRRITANT
HS Code  2933399990

N-Boc-1-[4-spiro-piperidine]-3-indanone price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR315463 tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 97% 159634-59-0 100mg $67 2026-06-04 Buy
Apolloscientific OR315463 tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 97% 159634-59-0 250mg $82 2026-06-04 Buy
Apolloscientific OR315463 tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 97% 159634-59-0 1g $151 2026-06-04 Buy
Apolloscientific OR315463 tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 97% 159634-59-0 5g $753 2026-06-04 Buy
Matrix Scientific 312839 tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate 159634-59-0 100.00mg $62 2026-05-19 Buy
Product number Packaging Price Buy
OR315463 100mg $67 Buy
OR315463 250mg $82 Buy
OR315463 1g $151 Buy
OR315463 5g $753 Buy
312839 100.00mg $62 Buy

N-Boc-1-[4-spiro-piperidine]-3-indanone Chemical Properties, Uses, Production

Synthesis

TERT-BUTYL 3-OXOSPIRO[INDAN-1,4'-PIPERIDINE]-1'-CARBOXYLATE

185525-42-2

N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE

159634-59-0

Tert-butyl 3-hydroxyspiro[indene-1,4'-piperidine]-1'-carboxylate (20 g, 66 mmol) was used as a raw material, which was dissolved in ethyl acetate (300 mL) and o-iodobenzoic acid (IBX) (37 g, 132 mmol) was added with stirring. The reaction mixture was heated to 80 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and the solid was separated by filtration. The filter cake was washed well with ethyl acetate (3 x 100 mL). The filtrate and washings were combined and concentrated under reduced pressure to give a solid residue. The residue was purified by silica gel column chromatography, first eluting with a 1:10 solvent mixture of ethyl acetate-hexane, and then switching to a 1:3 solvent mixture of ethyl acetate-hexane, to give 1'-(tert-butoxycarbonyl)-spiro-(indene-1,4'-piperidinium) (19.5 g, 98% yield) as a white solid with a melting point of 121 °C. The residue was purified by IR (KBr). The product was characterized by IR (KBr), 1H NMR (CDCl3,400 MHz), 13C NMR (CDCl3,100 MHz) and GC-MS (EI) to confirm its structure.

References

[1] Patent: WO2008/68159, 2008, A1. Location in patent: Page/Page column 28; 30
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 363 - 366
[3] Patent: WO2009/61681, 2009, A2. Location in patent: Page/Page column 65

N-Boc-1-[4-spiro-piperidine]-3-indanone synthesis

137419-24-0
159634-59-0
Synthesis of N-Boc-1-[4-spiro-piperidine]-3-indanone from CHEMBRDG-BB 4011973

N-Boc-1-[4-spiro-piperidine]-3-indanone Preparation Products And Raw materials

Raw materials

Tert-butyl bis(2-chloroethyl)carbamate tert-Butyl 2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate Ethyl acetate CHEMBRDG-BB 4011973 2-Iodoxybenzoic acid
tert-Butyl 3-oxospiro[indan-1,4'-piperidine]-1'-carboxylate Indene Borane-methyl sulfide complex

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Preparation Products

N-Boc-1-[4-spiro-piperidine]-3-indanone Suppliers

Global Suppliers ( 71)
Supplier Tel Email Country ProdList Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Xiannuo Biotechnology Co., Ltd. 021-50718719 13918719472 China 978 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
shanghai cooperpharm co.,LTD . +86-021-58975553 sales@cooperpharm.com China 1210 56
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2853 52
Shanghai Carlow Chemicals Co., Ltd. 21-33526724 18930996265 info@carlowchem.com China 1996 58
Supplier Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Pure Chemistry Scientific Inc. 62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Xiannuo Biotechnology Co., Ltd. 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
shanghai cooperpharm co.,LTD . 56
Shanghai Witofly Chemical Co.,Ltd 52
Shanghai Carlow Chemicals Co., Ltd. 58

View Latest Price from N-Boc-1-[4-spiro-piperidine]-3-indanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE pictures 2020-01-13 N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE
159634-59-0
 $6.68 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

N-Boc-1-[4-spiro-piperidine]-3-indanone Spectrum

N-BOC-1-[4-SPIRO-PIPERIDINE]-3-INDANONE(159634-59-0)1HNMR

159634-59-0 (N-Boc-1-[4-spiro-piperidine]-3-indanone) Related Search:

N-Boc-1-[4-spiro-piperidine]-3-indanone tert-Butyl 6-methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 3-oxo-6-(trifluoromethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 6-fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 7-cyano-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
tert-Butyl 4-cyano-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 6-chloro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 4-chloro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 5-methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 6-cyano-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
tert-Butyl 7-chloro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 3-oxo-4-(trifluoromethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 5-chloro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 5-fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 4-fluoro-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate
tert-Butyl 4-methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 7-methoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 5-cyano-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

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2,3-Dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester tert-butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-car Spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-3-oxo- 1,1-diMethyl ethyl ester Caboxylate 1'-Boc-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine] 2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester tert-butyl 3-oxospiro[2H-indene-1,4'-piperidine]-1'-carboxylate tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidine]-1'-carboxylate tert-butyl 3-oxo-2,3-dihydro-1'H-spiro[indene-1,4'-piperidin... 1,1-Dimethylethyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate 1’-Boc-3-oxo-2,3-dihydrospiro[indene-1,4’-piperidine tert-Butyl 2,3-dihydro-3-oxospiro[1H-indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate tert-Butyl 3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate N-Boc-1-[4-spiro-piperidine]-3-indanone 159634-59-0