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1-Bromo-2-methoxynaphthalene

1-Bromo-2-methoxynaphthalene Structure
1-Bromo-2-methoxynaphthalene structure
CAS No.
3401-47-6
Chemical Name:
1-Bromo-2-methoxynaphthalene
Synonyms
1-Bromo-2-methoxynapthalene;2-Methoxy-1-naphtyl bromide;1-Bromo-2-methoxynaphthalene;Naphthalene, 1-broMo-2-Methoxy-;1-Bromo-2-Naphthalene Methyl Ether;1-Bromo-2-methoxynaphthalene, >=97%;1-BROMO-2-METHOXYNAPHTHALENE,3401-47-6,OLED Intermediates,organic synthetic intermediate
CBNumber:
CB0312286
Molecular Formula:
C11H9BrO
Molecular Weight:
237.09
MDL Number:
MFCD00055374
MOL File:
3401-47-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:06
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1-Bromo-2-methoxynaphthalene Properties

Melting point 80-83 °C
Boiling point 190-192 °C(Press: 22 Torr)
Density 1.447±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
color White to Light yellow
Water Solubility Slightly soluble in water.
BRN 2045600
InChI InChI=1S/C11H9BrO/c1-13-10-7-6-8-4-2-3-5-9(8)11(10)12/h2-7H,1H3
InChIKey XNIGURFWNPLWJM-UHFFFAOYSA-N
SMILES C1(Br)=C2C(C=CC=C2)=CC=C1OC
CAS DataBase Reference 3401-47-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29093090
NFPA 704
1
0 0

1-Bromo-2-methoxynaphthalene price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B6103 1-Bromo-2-methoxynaphthalene 3401-47-6 5G $49 2026-04-30 Buy
TCI Chemical B6103 1-Bromo-2-methoxynaphthalene 3401-47-6 25G $170 2026-04-30 Buy
ChemScene CS-W004988 1-Bromo-2-methoxynaphthalene ≥98% 3401-47-6 25g $14 2026-06-04 Buy
ChemScene CS-W004988 1-Bromo-2-methoxynaphthalene ≥98% 3401-47-6 100g $48 2026-06-04 Buy
ChemScene CS-W004988 1-Bromo-2-methoxynaphthalene ≥98% 3401-47-6 500g $152 2026-06-04 Buy
Product number Packaging Price Buy
B6103 5G $49 Buy
B6103 25G $170 Buy
CS-W004988 25g $14 Buy
CS-W004988 100g $48 Buy
CS-W004988 500g $152 Buy

1-Bromo-2-methoxynaphthalene Chemical Properties, Uses, Production

Chemical Properties

solid

Uses

1-Bromo-2-methoxy-naphthalene is a useful synthetic intermediate. It is used as a reagent to synthesize a catalyst for highly enantioselective aziridination of styrene derivatives. It can also be used to prepare biaryls or biheterocycles by palladium-catalyzed Ullmann coupling.

Synthesis

1-Bromo-2-naphthol

573-97-7

Iodomethane

74-88-4

1-BROMO-2-METHOXYNAPHTHALENE

3401-47-6

In a 500 mL round-bottomed three-necked flask, 1-bromo-2-naphthol (30.0 g, 134.5 mmol), potassium hydroxide (KOH, 11.3 g, 201.7 mmol) and 300 mL of dimethylsulfoxide (DMSO) were added, and stirred under nitrogen protection for 10 min. Subsequently, the reaction system was cooled in an ice-water bath and iodomethane (28.6 g, 201.7 mmol) was added dropwise slowly. After the dropwise addition, stirring was continued at room temperature under nitrogen atmosphere for 12 h. The reaction was then warmed up to 50 °C for 1 h. The reaction was then completed by cooling to 50 °C for 10 min. After completion of the reaction, it was cooled to room temperature. The reaction mixture was poured into 500 mL of water and extracted with ether. The organic phase was washed three times with distilled water and dried over anhydrous magnesium sulfate (MgSO4). After the solvent was evaporated under reduced pressure, it was purified by silica gel column chromatography (eluent: n-hexane) to afford 1-bromo-2-methoxynaphthalene 22.0 g (yield 69.0%) as a white solid.

References

[1] Patent: KR2016/17530, 2016, A. Location in patent: Paragraph 0238; 0241; 0245; 0246
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 24, p. 4800 - 4818
[3] Journal of Organic Chemistry, 2000, vol. 65, # 5, p. 1511 - 1515
[4] Patent: JP5656843, 2015, B2. Location in patent: Paragraph 0092; 0093
[5] Journal of the Chemical Society, 1900, vol. 77, p. 37

1-Bromo-2-methoxynaphthalene Preparation Products And Raw materials

Raw materials

2-Methoxynaphthalene 1-Bromo-2-naphthol Iodomethane Potassium hydroxide Dimethyl sulfoxide

Preparation Products

2-Methoxy-1-naphthoic acid 3-Methoxynaphthalene-2-boronic acid (2-Methoxy-1-naphthyl)boronic acid 1,6-Dibromo-2-methoxynaphthalene

1-Bromo-2-methoxynaphthalene Suppliers

Global Suppliers ( 218)
Supplier Tel Email Country ProdList Advantage
Shanghai Enong Biotechnology Co., LTD 15821616017 2507465308@qq.com China 89 58
Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD 19963477321; 19963477321 2041275825@qq.com China 1541 58
Sanjing New Materials Technology (Taizhou) Co., Ltd. 13852622638 1048979734@qq.com China 778 58
Anhui Sun-wise Pharmaceutical Co., Ltd. 18856027890 18856027890 83618010@qq.com China 53 58
91610131MAETLLY230 18119371275 2536464251@qq.com China 428 58
Shaanxi pure crystal photoelectric technology co. LTD +86-13152027579 13152027579 2589440029@qq.com China 462 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Shanghai Enong Biotechnology Co., LTD 58
Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD 58
Sanjing New Materials Technology (Taizhou) Co., Ltd. 58
Anhui Sun-wise Pharmaceutical Co., Ltd. 58
91610131MAETLLY230 58
Shaanxi pure crystal photoelectric technology co. LTD 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 1-Bromo-2-methoxynaphthalene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-2-methoxynaphthalene pictures 2026-09-02 1-Bromo-2-methoxynaphthalene
3401-47-6
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
1-BROMO-2-METHOXYNAPHTHALENE pictures 2026-08-13 1-BROMO-2-METHOXYNAPHTHALENE
3401-47-6
 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
1-BROMO-2-METHOXYNAPHTHALENE pictures 2026-03-20 1-BROMO-2-METHOXYNAPHTHALENE
3401-47-6
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-2-methoxynaphthalene Spectrum

1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)MS1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)1HNMR1-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)IR11-BROMO-2-METHOXYNAPHTHALENE(3401-47-6)IR2

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2-Methoxy-1-naphtyl bromide Naphthalene, 1-broMo-2-Methoxy- 1-Bromo-2-methoxynapthalene 1-Bromo-2-methoxynaphthalene, >=97% 1-Bromo-2-Naphthalene Methyl Ether 1-BROMO-2-METHOXYNAPHTHALENE,3401-47-6,OLED Intermediates,organic synthetic intermediate 1-Bromo-2-methoxynaphthalene 3401-47-6 Ethers Organic Building Blocks Oxygen Compounds Building Blocks Ethers Organic Building Blocks Oxygen Compounds Building Blocks C11 Chemical Synthesis Organic Building Blocks Oxygen Compounds