4-Fluorothiophenol
- CAS No.
- 371-42-6
- Chemical Name:
- 4-Fluorothiophenol
- Synonyms
- 4-Fluorothiphenol;4-FLUOROBENZENETHIOL;P-FLUOROTHIOPHENOL;4-MERCAPTOFLUOROBENZENE;uorothiophenoL;Fluorothiophenol2;4-Fluorthiophenol;4-fluorothiophene;4-FLUOROTHIOPHENOL;p-Fluorobenzenethiol
- CBNumber:
- CB0312680
- Molecular Formula:
- C6H5FS
- Molecular Weight:
- 128.17
- MDL Number:
- MFCD00004846
- MOL File:
- 371-42-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Fluorothiophenol 98% | F15315 | 10g | $85.2 |
| 4-Fluorothiophenol 98% | F15315 | 25g | $89 |
| 4-Fluorobenzenethiol >98.0%(GC) | F0393 | 5g | $27 |
| 4-Fluorobenzenethiol >98.0%(GC) | F0393 | 25g | $74 |
| 4-Fluorothiophenol 98% | 5661-3-04 | 500g | $360 |
| More product size | |||
| Melting point | 43-46°C |
|---|---|
| Boiling point | 164-168 °C |
| Density | 1.203 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 130 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| pka | 6.40±0.10(Predicted) |
| Specific Gravity | 1.203 |
| color | Clear colorless to light yellow |
| Water Solubility | Not miscible or difficult to mix in water. |
| Sensitive | Stench |
| BRN | 1446350 |
| InChI | 1S/C6H5FS/c7-5-1-3-6(8)4-2-5/h1-4,8H |
| InChIKey | OKIHXNKYYGUVTE-UHFFFAOYSA-N |
| SMILES | Fc1ccc(S)cc1 |
| CAS DataBase Reference | 371-42-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 26-36-45-16-7/9 | |||||||||
| RIDADR | UN 3336 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 9-13-23 | |||||||||
| Hazard Note | Irritant/Stench | |||||||||
| TSCA | N | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309070 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Fluorothiophenol price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F15315 | 4-Fluorothiophenol 98% | 371-42-6 | 10g | $85.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | F15315 | 4-Fluorothiophenol 98% | 371-42-6 | 25g | $89 | 2026-04-30 | Buy |
| TCI Chemical | F0393 | 4-Fluorobenzenethiol >98.0%(GC) | 371-42-6 | 5g | $27 | 2026-04-30 | Buy |
| TCI Chemical | F0393 | 4-Fluorobenzenethiol >98.0%(GC) | 371-42-6 | 25g | $74 | 2026-04-30 | Buy |
| SynQuest Laboratories | 5661-3-04 | 4-Fluorothiophenol 98% | 371-42-6 | 500g | $360 | 2026-05-22 | Buy |
4-Fluorothiophenol Chemical Properties,Uses,Production
Chemical Properties
clear colorless to light yellow liquid
Uses
It is used in the synthesis of Bicalutamide, an anti-cancer drug.
Definition
ChEBI: 4-Fluorothiophenol is a thiol.
Synthesis
460-00-4
371-42-6
The general procedure for the synthesis of p-fluorothiophenol from p-bromofluorobenzene is as follows: In a Schlenk tube, pre-dried in an oven, the aryl halide p-bromofluorobenzene (0.5 mmol), sodium thiosulphate (100 mg), cesium carbonate (1 mmol, 325 mg), an appropriate amount of tris(dibenzylideneacetone)dipalladium/palladium acetate, and Xphos ligands were added in turn to the tube and placed in a magnetic stirring chamber. Sub. The Schlenk tube was evacuated and replaced three times with argon, followed by the addition of an appropriate amount of solvent. The reaction mixture was stirred at room temperature until uniformly dispersed. Next, the reaction tube was placed in an oil bath at 80°C and stirred for 24 hours. Upon completion of the reaction, the solids were separated by filtration and washed with ether. Zinc powder (0.5 g) and 10% hydrochloric acid solution (5 mL) were added to the resulting solid under cooling conditions in an ice water bath. After stirring for 1 h, the reaction mixture was extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product of p-fluorothiophenol of satisfactory purity. For part of the relatively stable product, it can be further purified by column chromatography.
References
[1] Tetrahedron Letters, 2011, vol. 52, # 2, p. 205 - 208
[2] Chemische Berichte, 1939, vol. 72, p. 594
[3] Journal of the Chemical Society, 1962, p. 1062 - 1067
4-Fluorothiophenol Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5231 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
View Lastest Price from 4-Fluorothiophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-29 | 4-Fluorothiophenol
371-42-6
|
US $233.00 / KG | 1KG | ≥98% | 10 tons | Yancheng Green Chemicals Co.,Ltd | |
 |
2026-05-28 | 4-Fluorothiophenol
371-42-6
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 4-Fluorothiophenol
371-42-6
|
US $10.00 / kg | 1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Fluorothiophenol
371-42-6
- US $233.00 / KG
- ≥98%
- Yancheng Green Chemicals Co.,Ltd
-
- 4-Fluorothiophenol
371-42-6
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-Fluorothiophenol
371-42-6
- US $10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
