4-Fluorobenzonitrile
- CAS No.
- 1194-02-1
- Chemical Name:
- 4-Fluorobenzonitrile
- Synonyms
- PFBN;P-FLUOROBENZONITRILE;For fluorobenzonitrile;4-fluoronitrile;4-florobenzonitrile;P-Fluorobenzonitile;4-fluoro-benzonitril;p-Cyanofluorobenzene;p-fluoro-benzonitril;4-CYANOFLUOROBENZENE
- CBNumber:
- CB5200760
- Molecular Formula:
- C7H4FN
- Molecular Weight:
- 121.11
- MDL Number:
- MFCD00001812
- MOL File:
- 1194-02-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 32-34 °C (lit.) |
|---|---|
| Boiling point | 188 °C/750 mmHg (lit.) |
| Density | 1.1070 |
| refractive index | 1.4925 |
| Flash point | 150 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Chloroform, Ethyl Acetate |
| form | Crystalline Low Melting Solid |
| color | White |
| Water Solubility | Insoluble in water. |
| BRN | 2041517 |
| Exposure limits | NIOSH: IDLH 25 mg/m3 |
| InChI | 1S/C7H4FN/c8-7-3-1-6(5-9)2-4-7/h1-4H |
| InChIKey | AEKVBBNGWBBYLL-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)C#N |
| CAS DataBase Reference | 1194-02-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4VJG35CQV3 |
| NIST Chemistry Reference | Benzonitrile, 4-fluoro-(1194-02-1) |
| EPA Substance Registry System | 4-Fluorobenzonitrile (1194-02-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H302+H312+H332 | |||||||||
| Precautionary statements | P210-P240-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 36/37-36/37/39-26-36 | |||||||||
| RIDADR | UN 1325 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DI4368500 | |||||||||
| Hazard Note | Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| HS Code | 29269095 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Flam. Sol. 1 |
|||||||||
| Toxicity | mouse,LD50,intraperitoneal,1gm/kg (1000mg/kg),Farmaco, Edizione Scientifica. Vol. 41, Pg. 41, 1986. | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Fluorobenzonitrile price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 139416 | 4-Fluorobenzonitrile 99% | 1194-02-1 | 5g | $56.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 139416 | 4-Fluorobenzonitrile 99% | 1194-02-1 | 25g | $64 | 2026-04-30 | Buy |
| TCI Chemical | F0221 | 4-Fluorobenzonitrile >99.0%(GC) | 1194-02-1 | 25g | $27 | 2026-04-30 | Buy |
| TCI Chemical | F0221 | 4-Fluorobenzonitrile >99.0%(GC) | 1194-02-1 | 100g | $58 | 2026-04-30 | Buy |
| Usbiological | 276745 | 4-Fluorobenzonitrile Asreported | 1194-02-1 | 100g | $366 | 2026-06-03 | Buy |
4-Fluorobenzonitrile Chemical Properties,Uses,Production
Chemical Properties
white crystalline low melting solid
Uses
4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.
Uses
4-Fluorobenzonitrile is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.
Definition
ChEBI: 4-Fluorobenzonitrile is a member of benzenes and a nitrile.
Application
The application of 4-Fluorobenzonitrile in medicinal chemistry has proven valuable, particularly in the design of novel drug candidates that target specific biological pathways. Additionally, 4-Fluorobenzonitrile is employed in the production of dyes and pigments, offering vibrant colors and improved performance in various formulations.
General Description
4-Fluorobenzonitrile undergoes metal-mediated coupling to yield eight-membered thorium(IV) tetraazamacrocycle. It undergoes condensation with diphenylamine to yield monomer 4-cyanotriphenylamine.
Synthesis
4-Fluorobenzonitrile is synthesised using 4-Fluorobenzyl alcohol as raw material by chemical reaction. The specific synthesis steps are as follows:
With respect to 2 mmol of each alcohol represented by the general formula (1), 4 ml of CH2Cl2 as a solvent, 0.05 equivalent of TEMPO as an N-nitrosyl compound, (A) t-BuOCl, (B) I 2 or (C ) N, N'-diiodo-5,5-dimethylhydantoin (DIH) were mixed in a predetermined amount and stirred for a predetermined time at room temperature.Next, 1.5 equivalents of I 2 and 4 ml of aqueous ammonia were added, and the mixture was stirred at room temperature for 2 hours.
Toxics Screening Level
The screening level is calculated assuming the mouse LD50 was 300 mg/kg and use of the equation from R232(1)(h), as follows. The initial threshold screening level (ITSL) for 4-Fiuorobenzonitrile is 0.5 μg/m3 annual averaging time.
4-Fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing XiLang Chemical Products Co., Ltd. | 18936048580 | chemxilang@163.com | China | 3909 | 58 |
| East Star Biotech (Suzhou) Co., Ltd. | 0512-62620298 17520198886 | 18636423@qq.com | China | 29 | 58 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Xintai Huabao Chemical Technology Co., LTD | 0538-6378866 13854877258 | 934928173@qq.com | China | 9 | 58 |
| Shandong Chengxu Chemical Co., Ltd | 0530-5159166 13508986527 | 347575402@qq.com | China | 17 | 58 |
| Shandong Luoheng Chemical Products Co., LTD | 17306359933 | 439300512@qq.com | China | 76 | 58 |
| Shandong Qianyuan Polymer Material Co. , Ltd. | 18678041314 18765609661 | 2547772582@qq.com | China | 987 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 4-Fluorobenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Fluorobenzonitrile
1194-02-1
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 4-Fluorobenzonitrile
1194-02-1
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-04-27 | 4-Fluorobenzonitrile
1194-02-1
|
1kg | 98% | 100tons | Shandong Vital Biotechnology Co., Ltd. |
-
- 4-Fluorobenzonitrile
1194-02-1
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Fluorobenzonitrile
1194-02-1
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-Fluorobenzonitrile
1194-02-1
- 98%
- Shandong Vital Biotechnology Co., Ltd.
1194-02-1(4-Fluorobenzonitrile)Related Search:
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