PF 4693627
- CAS No.
- 1312815-93-2
- Chemical Name:
- PF 4693627
- Synonyms
- PF 4693627;PF 4693627,PF4693627;PF 4693627 - PF 04693627;4-Piperidinecarboxamide, 1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-
- CBNumber:
- CB03146356
- Molecular Formula:
- C26H29Cl2N3O3
- Molecular Weight:
- 502.433
- MDL Number:
- MFCD28396403
- MOL File:
- 1312815-93-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
PF 4693627 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22768 | PF-4693627 ≥98% | 1312815-93-2 | 500μg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 22768 | PF-4693627 ≥98% | 1312815-93-2 | 1mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 22768 | PF-4693627 ≥98% | 1312815-93-2 | 5mg | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 22768 | PF-4693627 ≥98% | 1312815-93-2 | 10mg | $659 | 2026-04-30 | Buy |
| Biosynth | MCC81593 | PF-4693627 | 1312815-93-2 | 10mg | $1031.1 | 2026-06-04 | Buy |
PF 4693627 Chemical Properties, Uses, Production
Description
PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Uses
PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA)[1].
in vivo
PF-4693627 (10 mg/kg; orally) inhibits 63% of PGE2 production relative to vehicle control in Guinea pig carrageenan stimulated air pouch model[1].
PF-4693627 (1.0 mg/kg; i.v.) shows good bioavailability (59%) and modest half life (t1/2=3.7 h) in Sprague-Dawley rats[1].
| Animal Model: | Guinea pig with carrageenan stimulated air pouch inflammation model[1] |
| Dosage: | 10 mg/kg |
| Administration: | Administered orally |
| Result: | 63% PGE2 inhibition. |
| Animal Model: | Sprague-Dawley rats[1]. |
| Dosage: | 1.0 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Administered i.v. |
| Result: | Clearance (CL), volume of distribution (Vdss), t1/2, mean residence time (MRT) and bioavailability (F) is 12 mL/min/kg, 3.0 L/kg, 3.7 h, 4.42 h, 59%, respectively. |
References
[1] Arhancet GB, et al. Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1114-9. DOI:10.1016/j.bmcl.2012.11.109
PF 4693627 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 4693627 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
View Latest Price from PF 4693627 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | PF-4693627
1312815-93-2
|
$246.00-2160.00 | 10g | TargetMol Chemicals Inc. |
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- PF-4693627
1312815-93-2
- $246.00-2160.00
- TargetMol Chemicals Inc.
