10-METHYLPHENOTHIAZINE
- CAS No.
- 1207-72-3
- Chemical Name:
- 10-METHYLPHENOTHIAZINE
- Synonyms
- N-METHYLPHENOTHIAZINE;10-Methyl-10H-phenothiazine;AKOS 93806;10-METHYLPHENOTHIAZINE;2 - Methyl Phenothiazine;10-Methylphenothiazine>Phenothiazine, 10-methyl-;10-Methylphenothiazine,98%;10-Methylphenothiazine 98%;10-methyl-10h-phenothiazin
- CBNumber:
- CB0334226
- Molecular Formula:
- C13H11NS
- Molecular Weight:
- 213.3
- MDL Number:
- MFCD00041836
- MOL File:
- 1207-72-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 10-Methylphenothiazine 98% | 425346 | 5g | $92.2 |
| 10-Methylphenothiazine >98.0%(GC) | M2517 | 5g | $51 |
| 10-Methylphenothiazine ≥98%(GC) | 44034 | 5G | $88.33 |
| 10-Methylphenothiazine 98% | AA003DRG | 250mg | $5 |
| 10-Methylphenothiazine 98% | AA003DRG | 5g | $9 |
| Melting point | 99-101 °C (lit.) |
|---|---|
| Boiling point | 341.6±12.0 °C(Predicted) |
| Density | 1.1168 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 0.56±0.20(Predicted) |
| color | White to Light yellow |
| Water Solubility | Insoluble in water. |
| λmax | 310nm(CHCl3)(lit.) |
| InChI | InChI=1S/C13H11NS/c1-14-10-6-2-4-8-12(10)15-13-9-5-3-7-11(13)14/h2-9H,1H3 |
| InChIKey | QXBUYALKJGBACG-UHFFFAOYSA-N |
| SMILES | C1=C2C(SC3=C(N2C)C=CC=C3)=CC=C1 |
| CAS DataBase Reference | 1207-72-3(CAS DataBase Reference) |
| EPA Substance Registry System | 10H-Phenothiazine, 10-methyl- (1207-72-3) |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2934.30.5000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
10-METHYLPHENOTHIAZINE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 425346 | 10-Methylphenothiazine 98% | 1207-72-3 | 5g | $92.2 | 2026-04-30 | Buy |
| TCI Chemical | M2517 | 10-Methylphenothiazine >98.0%(GC) | 1207-72-3 | 5g | $51 | 2026-04-30 | Buy |
| Chem-Impex | 44034 | 10-Methylphenothiazine ≥98%(GC) | 1207-72-3 | 5G | $88.33 | 2026-05-19 | Buy |
| aablocks | AA003DRG | 10-Methylphenothiazine 98% | 1207-72-3 | 250mg | $5 | 2026-05-28 | Buy |
| aablocks | AA003DRG | 10-Methylphenothiazine 98% | 1207-72-3 | 5g | $9 | 2026-05-28 | Buy |
10-METHYLPHENOTHIAZINE Chemical Properties,Uses,Production
Chemical Properties
slightly yellow to pale green crystalline powder
Uses
They are used in pharmaceutical manufacturing especially antipsychotic drugs. Also used as a stabilizer against polymerization of acrylates.
Definition
ChEBI: 10-methylphenothiazine is a member of phenothiazines.
Synthesis
92-84-2
74-88-4
1207-72-3
General procedure for the synthesis of 10-methylphenothiazine from phenothiazine and iodomethane: NaH (60% purity, 1.0 g, 25.1 mmol) was slowly added to a 50 ml round-bottomed flask containing DMF (10 ml) under ice-water bath conditions. Iodomethane (1.3 g, 11.04 mmol) and phenothiazine (2 g, 10.0 mmol) were then added sequentially. The reaction mixture was transferred to room temperature and stirred for 2 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction was quenched by addition of water and extracted with dichloromethane (50 ml x 3). The organic phases were combined and dried with magnesium sulfate and subsequently concentrated to remove the solvent. Purification by silica gel column chromatography afforded the target product 10-methylphenothiazine (2.1 g, white solid) with a melting point of 96 °C in 97% yield.
Purification Methods
Recrystallise it (three times) from EtOH to give the -form (prisms). Recrystallisation from EtOH/*benzene gives the .-form (needles). It has also been purified by vacuum sublimation and is carefulmax 255nm (log 4.60) (pH 6.3) and 255nm in hexane. [Cymerman-Craig & Warburton Aust J Chem 9 294 1956, Beilstein 27 II 33, 27 III/IV 1215.]
References
[1] Molecular Crystals and Liquid Crystals, 2010, vol. 520, p. 36 - 43
[2] Patent: CN106045986, 2016, A. Location in patent: Paragraph 0039; 0040; 0041
[3] Patent: CN106045987, 2016, A. Location in patent: Paragraph 0039; 0040; 0041
[4] Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1053 - 1056
[5] ACS Chemical Neuroscience, 2017, vol. 8, # 4, p. 798 - 806
10-METHYLPHENOTHIAZINE Preparation Products And Raw materials
Raw materials
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Preparation Products
10-METHYLPHENOTHIAZINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9694 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43392 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32288 | 55 |
| Wuxi MinHua Biochem Pharmatech Co.,Ltd. | 0510-0510-66903969 13961776301 | mrweizhihua@sina.com | China | 44 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 10-METHYLPHENOTHIAZINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-08-12 | 10-METHYLPHENOTHIAZINE
1207-72-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-02 | 10-Methylphenothiazine
1207-72-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-02-02 | 10-METHYLPHENOTHIAZINE
1207-72-3
|
$1.00 | 1g | 99% | 200g | Career Henan Chemical Co |
-
- 10-METHYLPHENOTHIAZINE
1207-72-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 10-Methylphenothiazine
1207-72-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 10-METHYLPHENOTHIAZINE
1207-72-3
- $1.00
- 99%
- Career Henan Chemical Co
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