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4-Bromo-7-methyl-1H-indole

4-Bromo-7-methyl-1H-indole structure

CAS No.: 936092-87-4

Chemical Name:: 4-Bromo-7-methyl-1H-indole

Synonyms: 4-BROMO-7-METHYLINDOLE;4-Bromo-7-methyl-1H-indole;1H-Indole, 4-broMo-7-Methyl-

CBNumber:: CB0342285

Molecular Formula:: C9H8BrN

Molecular Weight:: 210.07

MDL Number:: MFCD08272256

MOL File:: 936092-87-4.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:18

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4-Bromo-7-methyl-1H-indole Properties

storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Appearance	Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H317
Precautionary statements	P280
HS Code	2933998090

4-Bromo-7-methyl-1H-indole price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR471099	4-Bromo-7-methylindole 95%	936092-87-4	100mg	$26	2026-06-04	Buy
Apolloscientific	OR471099	4-Bromo-7-methylindole 95%	936092-87-4	250mg	$39	2026-06-04	Buy
Apolloscientific	OR471099	4-Bromo-7-methylindole 95%	936092-87-4	1g	$108	2026-06-04	Buy
Apolloscientific	OR471099	4-Bromo-7-methylindole 95%	936092-87-4	5g	$515	2026-06-04	Buy
Apolloscientific	OR471099	4-Bromo-7-methylindole 95%	936092-87-4	25g	$1812	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR471099	100mg	$26	Buy
OR471099	250mg	$39	Buy
OR471099	1g	$108	Buy
OR471099	5g	$515	Buy
OR471099	25g	$1812	Buy

4-Bromo-7-methyl-1H-indole Chemical Properties, Uses, Production

Synthesis

60956-26-5

1826-67-1

936092-87-4

4-Bromo-1-methyl-2-nitrobenzene (11.57 mmol, 2.5 g) was dissolved in tetrahydrofuran (THF, 116 mL) under nitrogen protection and cooled to -40 °C. Vinylmagnesium bromide (46.28 mmol, 46 mL) was added slowly, keeping the reaction temperature at -40 °C. The reaction mixture was stirred at this temperature for 40 min before the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl). The aqueous layer was separated and extracted with ethyl acetate (2×). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and the solvent was concentrated. The crude product obtained was dissolved in THF (35 mL) and cooled to 0 °C. 0.5 N hydrochloric acid (HCl, 4.4 mL) was added slowly and the reaction mixture was stirred at 0 °C for 1 hour. Subsequently, the reaction was quenched with aqueous sodium bicarbonate (NaHCO3, 44 mL). The aqueous layer was separated and extracted with ethyl acetate (2×). The organic extracts were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and the solvent concentrated. The crude product was purified by fast column chromatography on silica gel, the eluent being a hexane solution of 11% ethyl acetate to give the pure 4-bromo-7-methyl-1H-indole (1.05 g, yield: 43%). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and LC-MS: 1H NMR δ 8.21 (1H, brs), 7.28-7.26 (1H, m), 7.21 (1H, d, J = 7.2 Hz), 6.87 (1H, d, J = 6.8 Hz), 6.63-6.61 (1H, m), 2.47 (3H, s); LC-MS: tR = 3.58 min, [M + H]+ not detected (Method 3).

References

[1] Patent: WO2013/149997, 2013, A1. Location in patent: Page/Page column 120-121
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2016, vol. 55B, # 9, p. 1117 - 1130
[3] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 93

4-Bromo-7-methyl-1H-indole Preparation Products And Raw materials

Raw materials

4-Bromo-2-nitrotoluene Vinylmagnesium bromide

Preparation Products

4-Bromo-7-methyl-1H-indole Suppliers

Global Suppliers ( 63)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan TCASChem Technology Co., Ltd.	027-86697669 13986148687	sales@tcaschem.com	China	3982	55
Wuhan Kaymke Chemical Co., Ltd.,	027-87342388 18086026008	sales@kaymke.com	China	3537	55
Shanghai Devinchem Ltd	027-65318838 13646286950	sales@devinchem.com	China	2983	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
ShangHai AmK Pharmaceutical Technology Co., Ltd.	微信 18019252918 18019252918	sale@amkchem.com	China	14982	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	025-66162170		China	7180	55
Shanghai CR Corporation Limited	13917420128 13062833949	fred.wen@crcorporation.cn	China	9769	58
Beijing YiboYuntian Technology Co., Ltd.	13811826434	lichen13811826434@126.com	China	701	58
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58

Supplier	Advantage
Wuhan TCASChem Technology Co., Ltd.	55
Wuhan Kaymke Chemical Co., Ltd.,	55
Shanghai Devinchem Ltd	58
Bide Pharmatech Ltd.	60
ShangHai AmK Pharmaceutical Technology Co., Ltd.	55
Amadis Chemical Company Limited	58
Nanjing KaiMubo Pharmaceutical Co., Ltd.	55
Shanghai CR Corporation Limited	58
Beijing YiboYuntian Technology Co., Ltd.	58
Aikon International Limited	58

4-Bromo-7-methyl-1H-indole Spectrum

4-BROMO-7-METHYL-1H-INDOLE(936092-87-4)¹HNMR

936092-87-4 (4-Bromo-7-methyl-1H-indole) Related Search:

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