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4-Bromo-6-fluoro (1H)indazole

4-Bromo-6-fluoro (1H)indazole structure

CAS No.: 885520-70-7

Chemical Name:: 4-Bromo-6-fluoro (1H)indazole

Synonyms: 4-Bromo-6-fluoro-1H-indole;1H-INDOLE, 4-BROMO-6-FLUORO

CBNumber:: CB32514830

Molecular Formula:: C8H5BrFN

Molecular Weight:: 214.03

MDL Number:: MFCD08272203

MOL File:: 885520-70-7.mol

MSDS File:: SDS

Last updated:2026-09-12 18:51:54

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4-Bromo-6-fluoro (1H)indazole Properties

Boiling point	315.1±22.0 °C(Predicted)
Density	1.750
storage temp.	Sealed in dry,Room Temperature
pka	15.47±0.30(Predicted)
Appearance	Off-white to light yellow Solid-Liquid Mixture
InChI	InChI=1S/C8H5BrFN/c9-7-3-5(10)4-8-6(7)1-2-11-8/h1-4,11H
InChIKey	DMOWKZSCECYXSE-UHFFFAOYSA-N
SMILES	N1C2=C(C(Br)=CC(F)=C2)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

4-Bromo-6-fluoro (1H)indazole price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Activate Scientific	AS37882	4-Bromo-6-fluoro-1H-indole 97%	885520-70-7	1g	$76	2026-06-04	Buy
Activate Scientific	AS37882	4-Bromo-6-fluoro-1H-indole 97%	885520-70-7	5g	$281	2026-06-04	Buy
Synthonix	B26142	4-Bromo-6-fluoro-1H-indole 97%	885520-70-7	100mg	$24	2026-05-06	Buy
Synthonix	B26142	4-Bromo-6-fluoro-1H-indole 97%	885520-70-7	250mg	$30	2026-05-06	Buy
Synthonix	B26142	4-Bromo-6-fluoro-1H-indole 97%	885520-70-7	1g	$60	2026-05-06	Buy

Product number	Packaging	Price	Buy
AS37882	1g	$76	Buy
AS37882	5g	$281	Buy
B26142	100mg	$24	Buy
B26142	250mg	$30	Buy
B26142	1g	$60	Buy

4-Bromo-6-fluoro (1H)indazole Chemical Properties, Uses, Production

Uses

4-BROMO-6-FLUORO (1H)INDAZOLE used in the preparation of PI3 kinase inhibitors.

Uses

Halogentated indole derivative used in the preparation of PI3 kinase inhibitors.

Synthesis

Pyrrolidine, 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-

1093066-65-9

885520-70-7

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene (7.49 g, 31.8 mmol) was used as a raw material, which was dissolved in dioxane (40 mL) and then DMF-DMA (21.0 mL, 158 mmol) and pyrrolidine (2.6 mL, 31.1 mmol) were added sequentially. The reaction mixture was heated at 100 °C for the reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent to afford 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-pyrrolidine as a dark red residue (10.0 g, theoretical amount). This pyrrolidine derivative (10.0 g, 31.7 mmol) was mixed with Raney nickel (suspended in water, 15 mL) in MeOH:THF (1:1, 150 mL), and hydrazine monohydrate (2.3 mL, 47.4 mmol) was added slowly at 0 °C, followed by stirring the mixture for 5 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc. The filtrates were combined and concentrated to dryness under reduced pressure to afford the title compound 4-bromo-6-fluoro-1H-indole as a light colored oil (2.57 g, 37% yield). NMR hydrogen spectrum (300 MHz, CDCl3) δH 6.57 (apparent triple peak, J = 2.7 Hz, 1H), 7.04 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.12 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.20-7.25 (multiple peaks, 1H), 8.25 (single peak, 1H).

References

[1] Patent: WO2008/152387, 2008, A1. Location in patent: Page/Page column 34
[2] Patent: WO2009/53716, 2009, A1. Location in patent: Page/Page column 56
[3] Patent: WO2008/152394, 2008, A1. Location in patent: Page/Page column 39
[4] Patent: WO2008/152390, 2008, A1. Location in patent: Page/Page column 54-55

4-Bromo-6-fluoro (1H)indazole synthesis

Synthesis of 4-Bromo-6-fluoro (1H)indazole from Ethenamine, 2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethyl-

4-Bromo-6-fluoro (1H)indazole Preparation Products And Raw materials

Raw materials

Pyrrolidine, 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]- Ethenamine, 2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethyl- 2-Bromo-4-fluoro-6-nitrotoluene HYDRAZINE Methanol

Water Tetrahydrofuran N,N-Dimethylformamide dimethyl acetal

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Preparation Products

1H-Indole-4-carbonitrile, 6-fluoro- 1-(benzenesulfonyl)-4-bromo-6-fluoro-1H-indole

4-Bromo-6-fluoro (1H)indazole Suppliers

Global Suppliers ( 115)

Supplier	Tel	Email	Country	ProdList	Advantage
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shenzhen Gre-syn Chemical Technology Co., Ltd.	13226079980	761330897@qq.com	China	1164	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Wuhan TCASChem Technology Co., Ltd.	027-86697669 13986148687	sales@tcaschem.com	China	4000	55
Wuhan Kaymke Chemical Co., Ltd.,	027-87342388 18086026008	sales@kaymke.com	China	3522	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	+86-28-85122536 85324413	market@astatech.cn	China	8016	55
Shanghai Devinchem Ltd	027-65318838 13646286950	sales@devinchem.com	China	2983	58
CEG Chemical Science&Technology Co., Ltd.	Mobile:13665161512		China	1784	58
Tianjin Anhao Biological Technology Co., Ltd.		sales@ahpharmatech.com	China	5734	55

Supplier	Advantage
Bide Pharmatech Ltd.	60
Shenzhen Gre-syn Chemical Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Chemsky (shanghai) International Co.,Ltd	60
Wuhan TCASChem Technology Co., Ltd.	55
Wuhan Kaymke Chemical Co., Ltd.,	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	55
Shanghai Devinchem Ltd	58
CEG Chemical Science&Technology Co., Ltd.	58
Tianjin Anhao Biological Technology Co., Ltd.	55

View Latest Price from 4-Bromo-6-fluoro (1H)indazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	4-BROMO-6-FLUORO (1H)INDAZOLE 885520-70-7	$1.00	1kg	98%	200KG	Career Henan Chemical Co

4-BROMO-6-FLUORO (1H)INDAZOLE
885520-70-7
$1.00
98%
Career Henan Chemical Co

4-Bromo-6-fluoro (1H)indazole Spectrum

4-BROMO-6-FLUORO (1H)INDAZOLE(885520-70-7)¹HNMR

885520-70-7 (4-Bromo-6-fluoro (1H)indazole) Related Search:

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