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4-BROMO-6-FLUORO (1H)INDAZOLE

4-BROMO-6-FLUORO (1H)INDAZOLE structure

CAS No.: 885520-70-7

Chemical Name:: 4-BROMO-6-FLUORO (1H)INDAZOLE

Synonyms: 4-Bromo-6-fluoro-1H-indole;1H-INDOLE, 4-BROMO-6-FLUORO

CBNumber:: CB32514830

Molecular Formula:: C8H5BrFN

Molecular Weight:: 214.03

MDL Number:: MFCD08272203

MOL File:: 885520-70-7.mol

Last updated:2025-10-14 17:28:43

Product description	Number	Pack Size	Price
4-Bromo-6-fluoroindole	B684400	1g	$1260
4-Bromo-6-fluoro-1H-indole	CS-W019334	250mg	$60
4-Bromo-6-fluoroindole	FB19167	2g	$600
4-Bromo-6-fluoroindole	FB19167	100mg	$75
4-Bromo-6-fluoro-1H-indole	Z5269	250mg	$132
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4-BROMO-6-FLUORO (1H)INDAZOLE Properties

Boiling point	315.1±22.0 °C(Predicted)
Density	1.750
storage temp.	Sealed in dry,Room Temperature
pka	15.47±0.30(Predicted)
Appearance	Off-white to light yellow Solid-Liquid Mixture
InChI	InChI=1S/C8H5BrFN/c9-7-3-5(10)4-8-6(7)1-2-11-8/h1-4,11H
InChIKey	DMOWKZSCECYXSE-UHFFFAOYSA-N
SMILES	N1C2=C(C(Br)=CC(F)=C2)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501

4-BROMO-6-FLUORO (1H)INDAZOLE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B684400	4-Bromo-6-fluoroindole	885520-70-7	1g	$1260	2021-12-16	Buy
ChemScene	CS-W019334	4-Bromo-6-fluoro-1H-indole	885520-70-7	250mg	$60	2021-12-16	Buy
Biosynth Carbosynth	FB19167	4-Bromo-6-fluoroindole	885520-70-7	2g	$600	2021-12-16	Buy
Biosynth Carbosynth	FB19167	4-Bromo-6-fluoroindole	885520-70-7	100mg	$75	2021-12-16	Buy
AK Scientific	Z5269	4-Bromo-6-fluoro-1H-indole	885520-70-7	250mg	$132	2021-12-16	Buy

Product number	Packaging	Price	Buy
B684400	1g	$1260	Buy
CS-W019334	250mg	$60	Buy
FB19167	2g	$600	Buy
FB19167	100mg	$75	Buy
Z5269	250mg	$132	Buy

4-BROMO-6-FLUORO (1H)INDAZOLE Chemical Properties,Uses,Production

Uses

4-BROMO-6-FLUORO (1H)INDAZOLE used in the preparation of PI3 kinase inhibitors.

Uses

Halogentated indole derivative used in the preparation of PI3 kinase inhibitors.

Synthesis

Pyrrolidine, 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-

1093066-65-9

885520-70-7

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene (7.49 g, 31.8 mmol) was used as a raw material, which was dissolved in dioxane (40 mL) and then DMF-DMA (21.0 mL, 158 mmol) and pyrrolidine (2.6 mL, 31.1 mmol) were added sequentially. The reaction mixture was heated at 100 °C for the reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent to afford 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-pyrrolidine as a dark red residue (10.0 g, theoretical amount). This pyrrolidine derivative (10.0 g, 31.7 mmol) was mixed with Raney nickel (suspended in water, 15 mL) in MeOH:THF (1:1, 150 mL), and hydrazine monohydrate (2.3 mL, 47.4 mmol) was added slowly at 0 °C, followed by stirring the mixture for 5 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc. The filtrates were combined and concentrated to dryness under reduced pressure to afford the title compound 4-bromo-6-fluoro-1H-indole as a light colored oil (2.57 g, 37% yield). NMR hydrogen spectrum (300 MHz, CDCl3) δH 6.57 (apparent triple peak, J = 2.7 Hz, 1H), 7.04 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.12 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.20-7.25 (multiple peaks, 1H), 8.25 (single peak, 1H).

References

[1] Patent: WO2008/152387, 2008, A1. Location in patent: Page/Page column 34
[2] Patent: WO2009/53716, 2009, A1. Location in patent: Page/Page column 56
[3] Patent: WO2008/152394, 2008, A1. Location in patent: Page/Page column 39
[4] Patent: WO2008/152390, 2008, A1. Location in patent: Page/Page column 54-55

4-BROMO-6-FLUORO (1H)INDAZOLE synthesis

Synthesis of 4-BROMO-6-FLUORO (1H)INDAZOLE from Ethenamine, 2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethyl-

4-BROMO-6-FLUORO (1H)INDAZOLE Preparation Products And Raw materials

Raw materials

Pyrrolidine, 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]- Ethenamine, 2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethyl- 2-BROMO-4-FLUORO-6-NITROTOLUENE HYDRAZINE Methanol

Water Tetrahydrofuran N,N-Dimethylformamide dimethyl acetal

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Preparation Products

1H-Indole-4-carbonitrile, 6-fluoro- 1-(benzenesulfonyl)-4-bromo-6-fluoro-1H-indole

4-BROMO-6-FLUORO (1H)INDAZOLE Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5661	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58
CR Corporation Limited	58

View Lastest Price from 4-BROMO-6-FLUORO (1H)INDAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	4-BROMO-6-FLUORO (1H)INDAZOLE 885520-70-7	US $1.00 / kg	1kg	98%	200KG	Career Henan Chemical Co

4-BROMO-6-FLUORO (1H)INDAZOLE
885520-70-7
US $1.00 / kg
98%
Career Henan Chemical Co

4-BROMO-6-FLUORO (1H)INDAZOLE Spectrum

4-BROMO-6-FLUORO (1H)INDAZOLE(885520-70-7)¹HNMR

885520-70-7(4-BROMO-6-FLUORO (1H)INDAZOLE)Related Search:

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1H-INDOLE, 4-BROMO-6-FLUORO 4-Bromo-6-fluoro-1H-indole 885520-70-7 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals