1-(Boc-amino)cyclopropanecarboxylic acid
- CAS No.
- 88950-64-5
- Chemical Name:
- 1-(Boc-amino)cyclopropanecarboxylic acid
- Synonyms
- BOC-ACPC-OH;Boc-ACC-OH;BOC-AC3C-OH;BOC-1, 1-ACCP;Boc-1-aminocycL;BOC-(1)NH-DELTA-OH;BOC-(1)NHCPROPN-OH;RARECHEM AR PA 0007;1-{[(tert-butoxy)carbonyl]amino};Boc-1-aminocyclopropyl formic acid
- CBNumber:
- CB0409746
- Molecular Formula:
- C9H15NO4
- Molecular Weight:
- 201.22
- MDL Number:
- MFCD00083257
- MOL File:
- 88950-64-5.mol
- MSDS File:
- SDS
| Melting point | 178 °C |
|---|---|
| Boiling point | 347.6±21.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.04±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| BRN | 4430628 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C9H15NO4/c1-8(2,3)14-7(13)10-9(4-5-9)6(11)12/h4-5H2,1-3H3,(H,10,13)(H,11,12) |
| InChIKey | DSKCOVBHIFAJRI-UHFFFAOYSA-N |
| SMILES | C1(NC(OC(C)(C)C)=O)(C(O)=O)CC1 |
| CAS DataBase Reference | 88950-64-5(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn,O | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-(Boc-amino)cyclopropanecarboxylic acid price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 39977 | 1-(Boc-amino)cyclopropanecarboxylic acid ≥98.0% (TLC) | 88950-64-5 | 1g | $572 | 2023-06-20 | Buy |
| TCI Chemical | B3138 | 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | 88950-64-5 | 5G | $127 | 2026-04-30 | Buy |
| TCI Chemical | B3138 | 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | 88950-64-5 | 25G | $380 | 2026-04-30 | Buy |
| Usbiological | 266539 | Boc-1-aminocyclopropane-1-carboxylic acid Asreported | 88950-64-5 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 266539 | Boc-1-aminocyclopropane-1-carboxylic acid Asreported | 88950-64-5 | 1g | $476 | 2026-06-03 | Buy |
1-(Boc-amino)cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Description
1-(Boc-amino)cyclopropanecarboxylic acid is an important organic compound. It is used in the biological field for the synthesis of irreversible inhibitors of tetrapeptide carboxypeptidases, leading to covalent substrate modifications; preparation of combinatorial libraries. It is used in the synthetic field as a pharmaceutical synthesis intermediate.
Chemical Properties
White crystalline powder
Uses
1-(Boc-amino)cyclopropanecarboxylic Acid is used as a reagent in the synthesis of pyrrolotriazinone derivatives as therapeutic PI3K inhibitors. Also used as a reagent in the synthesis of ether, carbamate and ester derivatives of adarotene as potential antitumor agents.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
68781-13-5
88950-64-5
General procedure for the synthesis of Boc-1-aminocyclopropanecarboxylic acid from di-tert-butyl dicarbonate and 1-aminocyclopropanecarboxylic acid hydrochloride: 4.18 g (30.37 mmol) of 1-aminocyclopropanecarboxylic acid hydrochloride was dissolved in 61 ml of dichloromethane and 4.7 ml (33.40 mmol) of triethylamine (TEA) was added. The mixture was stirred for 10 minutes and then the dichloromethane was removed by evaporation under reduced pressure. The reaction was dissolved in a solvent mixture of 36.5 ml of 1N NaOH solution and 101 ml of 1,4-dioxane, followed by the addition of 8.4 ml (36.44 mmol) of di-tert-butyl dicarbonate (Boc2O). The reaction mixture was stirred at room temperature for 16 h, after which the 1,4-dioxane was removed by evaporation under reduced pressure. The residue was acidified to pH 3 with 1N HCl and then extracted with 3100 ml of ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and after evaporation of the solvent under reduced pressure, 3.59 g of 1-(tert-butoxycarbonylamino)cyclopropylacetic acid was obtained in 59% yield. The product was characterized by 1H NMR (400 MHz, MeOD): δ 1.51 (s, 2H), 1.51 (s, 9H), 1.44 (s, 4H).
References
[1] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0088; 0089
[2] Tetrahedron, 2013, vol. 69, # 16, p. 3495 - 3505
1-(Boc-amino)cyclopropanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Hexin Chengsai Science and Technology Development Co., Ltd. | 022-23410962 13752273685 | suna@hisyntech.com | China | 299 | 58 |
| Shanghai Jiajie Biotechnology Co., Ltd | 19542788059 | sales@jonellchem.com | China | 424 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 1-(Boc-amino)cyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
||
 |
2021-08-12 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
