4-(Piperidin-4-yl)-morpholine
- CAS No.
- 436099-97-7
- Chemical Name:
- 4-(Piperidin-4-yl)-morpholine
- Synonyms
- AKOS BB-9182;CHEMBRDG-BB 4004473;TIMTEC-BB SBB010091;morpholine 2,2,2-trifluoroacetate;4-piperidinium-4-ylmorpholin-4-ium;4-(4-Piperidinyl)Morpholine trifluoroacetate;4-(4-piperidinyl)Morpholine2,2,2-trifluoroacetate;4-(piperidin-4-yl)Morpholine 2,2,2-trifluoroacetate
- CBNumber:
- CB0423548
- Molecular Formula:
- C11H19F3N2O3
- Molecular Weight:
- 284.28
- MDL Number:
- MFCD06801222
- MOL File:
- 436099-97-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
4-(Piperidin-4-yl)-morpholine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 008595 | 4-Piperidin-4-yl-morpholinetrifluoroacetate | 436099-97-7 | 1.00g | $378 | 2026-05-18 | Buy |
| aablocks | AA00I89H | 4-(Piperidin-4-Yl)Morpholine 2,2,2-Trifluoroacetate | 436099-97-7 | 1g | $523 | 2026-05-29 | Buy |
| Crysdot | CD11123958 | 4-(Piperidin-4-yl)morpholine 2,2,2-trifluoroacetate 95+% | 436099-97-7 | 25g | $347 | 2026-05-26 | Buy |
| AK Scientific | 3533AE | 4-Piperidin-4-yl-morpholinetrifluoroacetate | 436099-97-7 | 250mg | $73 | 2021-12-16 | Buy |
| Matrix Scientific | 008595 | 4-Piperidin-4-yl-morpholinetrifluoroacetate | 436099-97-7 | 1g | $378 | 2021-12-16 | Buy |
4-(Piperidin-4-yl)-morpholine Chemical Properties, Uses, Production
Synthesis
76-05-1
53617-35-9
436099-97-7
General procedure for the synthesis of 4-morpholinopiperidine trifluoroacetate from 2,2,2-trifluoroacetic acid and 4-(4-piperidinyl)morpholine: To a stirred solution of tert-butyl 4-oxo-piperidine-1-carboxylate (3.0 g, 15 mmol) in THF (25 mL) were sequentially added morpholine (1.56 g, 18 mmol) and tetraisopropyl titanate (5.58 mL). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, ethanol (15 mL) was added followed by sodium cyanoborohydride (0.63 g, 10.05 mmol). The resulting mixture was stirred at room temperature overnight and the reaction was quenched by the addition of water (4 mL). After continued stirring for 30 min, the white solid was removed by filtration and the filtrate was concentrated by evaporation. The residue was partitioned between ether and water, and the organic layer was separated and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give a white solid. The solid was dissolved in 40 mL of 50% trifluoroacetic acid in dichloromethane solution and stirred at room temperature for 1 hour before removing the solvent. The residue was lyophilized to give the target product 4-morpholinopiperidine trifluoroacetate as a white solid (5.48 g, 98% yield). Mass spectrometry analysis showed that the (M+H)+ peak was located at m/z 171.
References
[1] Patent: US2005/239843, 2005, A1. Location in patent: Page/Page column 15
4-(Piperidin-4-yl)-morpholine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| ExcelChemical (Shanghai) Chemical Technology Co., Ltd. | +86 13671938079 | China | 39 | 55 | |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
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