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4-Morpholinopiperidine

4-Morpholinopiperidine Structure
4-Morpholinopiperidine structure
CAS No.
53617-35-9
Chemical Name:
4-Morpholinopiperidine
Synonyms
AKOS BB-9182;CHEMBRDG-BB 4004473;TIMTEC-BB SBB010091;4-Morpholino-piperidin;4-MORPHOLINOPIPERIDINE; Alectinib Impurity 27;4-(4-Piperidyl)morpholine;4-(Morpholin-4-yl)piperidine;4-(4-Piperidinyl) morpholine;Morpholine,4-(4-piperidinyl)-
CBNumber:
CB7423547
Molecular Formula:
C9H18N2O
Molecular Weight:
170.25
MDL Number:
MFCD03274733
MOL File:
53617-35-9.mol
MSDS File:
SDS
Last updated:2026-05-28 03:22:39
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4-Morpholinopiperidine Properties

Melting point 40-43 °C(lit.)
Boiling point 100-115 °C0.15-0.20 mm Hg(lit.)
Density 1.033±0.06 g/cm3(Predicted)
vapor pressure 0.63-4.58Pa at 25-45℃
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Solid
pka 10.21±0.10(Predicted)
Appearance Colorless to off-white Solid
InChI InChI=1S/C9H18N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h9-10H,1-8H2
InChIKey YYBXNWIRMJXEQJ-UHFFFAOYSA-N
SMILES N1(C2CCNCC2)CCOCC1
LogP 0.3 at 25℃ and pH11
Dissociation constant 5.44-10.1 at 20℃
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-36/37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active

4-Morpholinopiperidine price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 578045 4-Morpholinopiperidine 98% 53617-35-9 1g $34.7 2026-04-30 Buy
Sigma-Aldrich 578045 4-Morpholinopiperidine 98% 53617-35-9 5g $70.7 2026-04-30 Buy
Apolloscientific OR0953 4-(Piperidin-4-yl)morpholine 97% 53617-35-9 1g $21 2026-06-04 Buy
Apolloscientific OR0953 4-(Piperidin-4-yl)morpholine 97% 53617-35-9 5g $24 2026-06-04 Buy
AK Scientific Q685 4-Morpholino piperidine 98%(GC) 53617-35-9 1g $16 2026-06-04 Buy
Product number Packaging Price Buy
578045 1g $34.7 Buy
578045 5g $70.7 Buy
OR0953 1g $21 Buy
OR0953 5g $24 Buy
Q685 1g $16 Buy

4-Morpholinopiperidine Chemical Properties, Uses, Production

Uses

Reactant for synthesis of:

  • Selective adenosine A2A receptor antagonists
  • Antidepressents
  • Small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells
  • Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
  • Quinoline derivatives with antimicrobial activity
  • Antimalarials

Synthesis

4-(1-benzyl-piperidin-4-yl)-morpholine

415967-79-2

4-Morpholinopiperidine

53617-35-9

General procedure for the synthesis of 4-(4-piperidinyl)morpholine from N-benzyl-4-(4-morpholinyl)piperidine: 41.59 g (0.16 mol) of N-benzyl-4-(4-morpholinyl)piperidine was dissolved in 400 mL of methanol, and 5.2 g of 10% palladium/carbon catalyst was added. The hydrogenation reaction was carried out at room temperature for 18 hours at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. A colorless oily substance was obtained, which was left to crystallize. The yield was 25.29 g with 93% yield.

References

[1] Patent: US2008/45705, 2008, A1. Location in patent: Page/Page column 10-11
[2] Patent: US2003/69297, 2003, A1
[3] Patent: US2003/125370, 2003, A1

4-Morpholinopiperidine synthesis

415967-79-2
53617-35-9
Synthesis of 4-Morpholinopiperidine from 4-(1-benzyl-piperidin-4-yl)-morpholine

4-Morpholinopiperidine Preparation Products And Raw materials

Raw materials

1-boc-4-morpholinopiperdine 4-(1-benzyl-piperidin-4-yl)-morpholine Morpholine N-(tert-Butoxycarbonyl)-4-piperidone Methanol
Hydrogen

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Preparation Products

4-Morpholinopiperidine Suppliers

Global Suppliers ( 273)
Supplier Tel Email Country ProdList Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Shanghai Famo Bio-chemical Technology Company Ltd. 021-36680027 15821745250 fengqiang@famobiotech.com China 494 56
Sichuan aibike Pharmaceutical Technology Co., Ltd 028-68517313 18428121256 wangxinlong@emtco.cn China 22 58
Rushpharm Co.,Ltd. 025-66042949 15161141411 2244332520@qq.com China 55 58
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
Shandong Meiao Huawei Technology Co., LTD 0531-88682301 18595278766 yuhongmeng@mayowell.com China 88 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Shanghai Famo Bio-chemical Technology Company Ltd. 56
Sichuan aibike Pharmaceutical Technology Co., Ltd 58
Rushpharm Co.,Ltd. 58
Shanghai Hobor Chemical Co., Ltd 60
Shandong Meiao Huawei Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Sichuan Tongsheng Amino acids Co.,Ltd. 66
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 4-Morpholinopiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Morpholinopiperidine pictures 2026-09-02 4-Morpholinopiperidine
53617-35-9
 $1.10-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
Alectinib Impurity pictures 2025-12-16 Alectinib Impurity
53617-35-9
 10mg 95%+ 100000 Moxin Chemicals
Alectinib Impurity 27 pictures 2025-12-16 Alectinib Impurity 27
53617-35-9
 10mg 95%+ 1000000 Moxin Chemicals

4-Morpholinopiperidine Spectrum

4-Morpholinopiperidine(53617-35-9)1HNMR4-Morpholinopiperidine(53617-35-9)IR

53617-35-9 (4-Morpholinopiperidine) Related Search:

Phenylpropiolaldehyde Phenylpropyl aldehyde 2,2-Dimorpholinodiethylether 4-Aminopiperidine 4-methylaminopiperidine dihydrochloride
(R)-3-Aminopiperidine N-methylpiperidin-3-amine N,N-Dimethylpiperidin-4-amine 4-Piperidinopiperidine Alectinib
tert-butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate 4-(Piperidin-4-yl)-morpholine 4-Morpholinopiperidine 2,6-Dimethyl-4-piperidin-4-yl-morpholine dihydrochloride 2,6-Dimethyl-4-piperidin-4-yl-morpholine
N-(piperidin-4-yl)morpholine-4-sulfonamide 4-[1-(6-Chloro-pyrimidin-4-yl)-piperidin-4-yl]-morpholine 4-Morpholin-4-yl-piperidine-4-carboxylic aciddihydrochloride

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TIMTEC-BB SBB010091 4-(PIPERIDIN-4-YL)-MORPHOLINE AKOS BB-9182 CHEMBRDG-BB 4004473 4-Morpholino-piperidin 4-(PIPERIDIN-4-YL)-MORPHOLINE >98% 4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE 4-piperidin-4-ylmorpholine(SALTDATA: 2HCl) 4-piperidin-4-ylmorpholine 2HCl 4-(Morpholin-4-yl)piperidine Morpholine,4-(4-piperidinyl)- 4-(4-Piperidinyl) morpholine 4-(Piperidin-4-yl)-morpholinFree state 4-(4-Piperidyl)morpholine 4-MORPHOLINOPIPERIDINE TIANFU CHEM---4-(PIPERIDIN-4-YL)-MORPHOLINE Alectinib Impurity 27 53617-35-9 Heterocyclic Building Blocks Piperidines Building Blocks Building Blocks Heterocyclic Building Blocks Piperidines