2-Hydroxy-6-methyl-5-nitropyridine
- CAS No.
- 28489-45-4
- Chemical Name:
- 2-Hydroxy-6-methyl-5-nitropyridine
- Synonyms
- 6-METHYL-5-NITROPYRIDIN-2-OL;2-Hydroxy-6-methyL;6-Methyl-5-nitro-2-pyridone;6-HYDROXY-3-NITRO-2-PICOLINE;6-METHYL-5-NITRO-2-PYRIDINOL;2-Hydorxy-5-Nitro-6-Picoline;2-HYDROXY-5-NITRO-6-PICOLINE;and6-HYDROXY-3-NITRO-2-PICOLINE;6-Hydroxy-3-nitro-2-picoline,98%;6-Methyl-5-nitropyridin-2(1H)-one
- CBNumber:
- CB0432362
- Molecular Formula:
- C6H6N2O3
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD00092010
- MOL File:
- 28489-45-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 230-232 °C |
|---|---|
| Boiling point | 277.46°C (rough estimate) |
| Density | 1.4564 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Dimethylformamide |
| pka | 8.16±0.10(Predicted) |
| form | Crystalline Powder |
| color | Light brown to brown |
| InChI | InChI=1S/C6H6N2O3/c1-4-5(8(10)11)2-3-6(9)7-4/h2-3H,1H3,(H,7,9) |
| InChIKey | AJDDHNXZBGZBJN-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(C)=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 28489-45-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
2-Hydroxy-6-methyl-5-nitropyridine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1160 | 6-Hydroxy-2-methyl-3-nitropyridine >98.0%(GC)(T) | 28489-45-4 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | H1160 | 6-Hydroxy-2-methyl-3-nitropyridine >98.0%(GC)(T) | 28489-45-4 | 5g | $73 | 2026-04-30 | Buy |
| Apolloscientific | OR40439 | 6-Hydroxy-2-methyl-3-nitropyridine >98% | 28489-45-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR40439 | 6-Hydroxy-2-methyl-3-nitropyridine >98% | 28489-45-4 | 25g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR40439 | 6-Hydroxy-2-methyl-3-nitropyridine >98% | 28489-45-4 | 100g | $98 | 2026-06-04 | Buy |
2-Hydroxy-6-methyl-5-nitropyridine Chemical Properties, Uses, Production
Chemical Properties
Light yellow cryst
Uses
2-Hydroxy-6-methyl-5-nitropyridine is a versatile building block that can be used to create a range of compounds, such as 3-Amino-2-methylpyridine, 6-Chloro-2-methyl-3-nitropyridine, etc.
Synthesis
22280-62-2
28489-45-4
General procedure for the synthesis of 2-hydroxy-6-methyl-5-nitropyridine from 2-amino-5-nitro-6-methylpyridine: (b) 6-amino-3-nitro-2-methylpyridine (20 g, 0.131 mol) was suspended in a mixture of concentrated hydrochloric acid, H2SO4 (23.7 ml) and water (335 ml). H2SO4 (20 ml) was added slowly under cooling in an ice bath, at which point the amine was not completely dissolved. The suspension was poured into ice (100 g), followed by the addition of NaNO2 (13.53 g, 0.196 mol) solution in water (40 ml) drop by drop. Gas escaped during the reaction. The brown suspension was stirred at 10 °C for 1 h. Subsequently, it was filtered and the precipitate was washed with cold water. The resulting brown product was dried in a freeze dryer to give a final 15.78 g of 6-hydroxy-3-nitro-2-methylpyridine in 78% yield.
References
[1] Patent: WO2005/42464, 2005, A1. Location in patent: Page/Page column 33
[2] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[3] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0020
[4] Journal of the American Chemical Society, 1952, vol. 74, p. 3828,3830
[5] Yakugaku Zasshi, 1952, vol. 72, p. 434
2-Hydroxy-6-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Xiaochang Pharmaceutical Trading Co., Ltd. | 0513-82104991 18862997351 | sales11@btcpharm.com | China | 859 | 58 |
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1341 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from 2-Hydroxy-6-methyl-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-08-12 | 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Hydroxy-6-methyl-5-nitropyridine
28489-45-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
