2-Bromo-2-methylpropionic acid
- CAS No.
- 2052-01-9
- Chemical Name:
- 2-Bromo-2-methylpropionic acid
- Synonyms
- 2-Bromo-2-methylpropanoic acid;2-BROMOISOBUTYRIC ACID;Isobromobutyric acid;A-BROMOISOBUTYRIC ACID;2-bromo-2-methyl-Propanoicacid;2-broMo isobutyrate;α-Bromoisobutyric acid;α-Bromoisobutyric acid;pha-Bromoisobutyric acid;ALPHA-BROMOISOBUTYRIC ACID
- CBNumber:
- CB0433637
- Molecular Formula:
- C4H7BrO2
- Molecular Weight:
- 167
- MDL Number:
- MFCD00004168
- MOL File:
- 2052-01-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-2-methylpropionic acid 98% | 306851 | 25g | $53.6 |
| 2-Bromo-2-methylpropionic acid 98% | 306851 | 100g | $152 |
| 2-Bromoisobutyric Acid >98.0%(GC) | B0605 | 25g | $33 |
| 2-Bromoisobutyric Acid >98.0%(GC) | B0605 | 100g | $84 |
| 2-Bromoisobutyric Acid >98.0%(GC) | B0605 | 500g | $267 |
| More product size | |||
| Melting point | 44-47 °C(lit.) |
|---|---|
| Boiling point | 198-200 °C(lit.) |
| Density | 1.43 g/cm3 |
| refractive index | 1.4570 (estimate) |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | soluble in Chloroform, Methanol |
| form | Liquid |
| pka | 2.91±0.10(Predicted) |
| color | Clear colorless to slightly yellow |
| Water Solubility | Soluble in alcohol and ether. Slightly soluble in water. |
| Merck | 14,1421 |
| BRN | 1745543 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C4H7BrO2/c1-4(2,5)3(6)7/h1-2H3,(H,6,7) |
| InChIKey | XXSPGBOGLXKMDU-UHFFFAOYSA-N |
| SMILES | CC(C)(Br)C(O)=O |
| CAS DataBase Reference | 2052-01-9(CAS DataBase Reference) |
| FDA UNII | 821P2R6B0A |
| NIST Chemistry Reference | «alpha»-Bromoisobutyric acid(2052-01-9) |
| EPA Substance Registry System | Propanoic acid, 2-bromo-2-methyl- (2052-01-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45-25 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 13 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29156000 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2-Bromo-2-methylpropionic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 306851 | 2-Bromo-2-methylpropionic acid 98% | 2052-01-9 | 25g | $53.6 | 2025-07-31 | Buy |
| Sigma-Aldrich | 306851 | 2-Bromo-2-methylpropionic acid 98% | 2052-01-9 | 100g | $152 | 2025-07-31 | Buy |
| TCI Chemical | B0605 | 2-Bromoisobutyric Acid >98.0%(GC) | 2052-01-9 | 25g | $33 | 2025-07-31 | Buy |
| TCI Chemical | B0605 | 2-Bromoisobutyric Acid >98.0%(GC) | 2052-01-9 | 100g | $84 | 2025-07-31 | Buy |
| TCI Chemical | B0605 | 2-Bromoisobutyric Acid >98.0%(GC) | 2052-01-9 | 500g | $267 | 2025-07-31 | Buy |
2-Bromo-2-methylpropionic acid Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
2-Bromo-2-methylpropionic acid is used in the Herceptin functionalization of polyhedral oligomeric silsesquioxane-conjugated oligomers-silica /iron oxide nanoparticles for tumor cell sorting.
Uses
2-Bromoisobutyric acid is used in the synthesis of dextran macroinitiator for atom transfer radical polymerization (ATRP) by partial esterification of hydroxyl group of the polysaccharide. The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
General Description
The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.
Synthesis
79-31-2
630-51-3
2052-01-9
The general procedure for the synthesis of 2,2,3,3-tetramethylbutanedioic acid and 2-bromo isobutyric acid using isobutyric acid as starting material was as follows: 0.005 moles of carboxylic acid 1 was dissolved in 20 mL of anhydrous THF under argon protection, followed by the slow dropwise addition of this solution to a pre-cooled 0.01 moles of LDA (lithium diisopropylammonium) in 30 mL of anhydrous THF. The reaction mixture was gradually warmed to 35-40°C and stirred at this temperature for 30-40 minutes. Upon completion of the reaction, the mixture was cooled to 20-25°C, followed by addition of 0.005 moles of a solution of N,N-diethyl-N-halogenated amine 3 in 20 mL of anhydrous THF. The resulting mixture was continued to be stirred for 2 hours. At the end of the reaction, it was diluted with 30 ml of distilled water and the pH was adjusted with HCl to 1. The reaction product was extracted with ether (3 x 30 ml) and the combined organic phases were dried over anhydrous Na2SO4 and subsequently concentrated. Removal of the ether gave a mixture of dicarboxylic acids 8a-8c and α-halocarboxylic acids 9a-9f. The structures of the products were confirmed by 1H NMR and 13C NMR spectroscopic analyses and the data were in agreement with those reported in the literature [2,3].
References
[1] Russian Journal of General Chemistry, 2016, vol. 86, # 11, p. 2469 - 2472
[2] Zh. Obshch. Khim., 2016, vol. 86, # 11, p. 1826 - 1829,4
2-Bromo-2-methylpropionic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5241 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13800 | 58 |
| Yancheng Longshen Chemical Co.,Ltd. | +86-18352073383 +86-18352073383 | sales@longshenchem.com | China | 100 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21596 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 2-Bromo-2-methylpropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-02-27 | 2-Bromo-2-methylpropionic acid
2052-01-9
|
US $0.00 / KG | 1KG | ≥98% | 40 Tons/Month | Yancheng Longshen Chemical Co.,Ltd. | |
 |
2026-01-30 | 2-Bromo-2-methylpropionic acid
2052-01-9
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-27 | 2-Bromo-2-methylpropionic acid
2052-01-9
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2-Bromo-2-methylpropionic acid
2052-01-9
- US $0.00 / KG
- ≥98%
- Yancheng Longshen Chemical Co.,Ltd.
-
- 2-Bromo-2-methylpropionic acid
2052-01-9
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Bromo-2-methylpropionic acid
2052-01-9
- US $0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
