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4-Iodopyrazole

4-Iodopyrazole Structure
4-Iodopyrazole structure
CAS No.
3469-69-0
Chemical Name:
4-Iodopyrazole
Synonyms
4-IODO-1H-PYRAZOLE;4 - iodine pyrazole;4-iodopyrazol;4-IODOPYRAZOLE;4-Lodophrazole;4-LODO PYRAZOLE;4-iodopyrazole 4-;4-Iodopyrazole>4-IODOPYRAZOLE 99%;4-Iodopyrazole ,98%
CBNumber:
CB0456472
Molecular Formula:
C3H3IN2
Molecular Weight:
193.97
MDL Number:
MFCD00005244
MOL File:
3469-69-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:43:23
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4-Iodopyrazole Properties

Melting point 108-110 °C (lit.)
Boiling point 291.9±13.0 °C(Predicted)
Density 2.335±0.06 g/cm3(Predicted)
RTECS UQ7145000
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 12.99±0.50(Predicted)
form Crystalline Powder
color White to off-white
Water Solubility Soluble in water.
Sensitive Light Sensitive
InChI InChI=1S/C3H3IN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey LLNQWPTUJJYTTE-UHFFFAOYSA-N
SMILES N1C=C(I)C=N1
CAS DataBase Reference 3469-69-0(CAS DataBase Reference)
FDA UNII F33UJD465Q
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29331990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Iodopyrazole price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 213993 4-Iodopyrazole 99% 3469-69-0 10g $97.3 2026-04-30 Buy
TCI Chemical I0692 4-Iodopyrazole >98.0%(GC)(T) 3469-69-0 5g $35 2026-04-30 Buy
TCI Chemical I0692 4-Iodopyrazole >98.0%(GC)(T) 3469-69-0 25g $123 2026-04-30 Buy
Usbiological 280718 4-Iodopyrazole Asreported 3469-69-0 25g $319 2026-06-03 Buy
Usbiological 280718 4-Iodopyrazole Asreported 3469-69-0 50g $439 2026-06-03 Buy
Product number Packaging Price Buy
213993 10g $97.3 Buy
I0692 5g $35 Buy
I0692 25g $123 Buy
280718 25g $319 Buy
280718 50g $439 Buy

4-Iodopyrazole Chemical Properties, Uses, Production

Chemical Properties

White or off-white solid

Uses

4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.

Uses

4-Iodopyrazole was used in an indium-mediated synthesis of heterobiaryls.

Definition

ChEBI: 4-iodopyrazole is a member of pyrazoles and an organoiodine compound.

General Description

4-Iodopyrazole is a valuable intermediate for the synthesis of biologically active compounds. It undergoes iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole.

Synthesis

Pyrazole

288-13-1

4-Iodopyrazole

3469-69-0

The general procedure for the synthesis of 4-iodopyrazole from pyrazole is as follows: Example 1: Preparation of 2-amino-3-methyl-5-(1-methyl-1H-pyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)-3,5-dihydro-4H-imidazol-4-one Step a): Preparation of compound 2 A mixture of pyrazole (3.00 g, 44.0 mmol), iodine (6.71 g, 26.4 mmol) and ceric ammonium nitrate (14.5 g, 26.4 mmol) in acetonitrile (400 mL) was stirred at room temperature for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and partitioned between ethyl acetate (250 mL) and 5% aqueous sodium bisulfite (250 mL). After addition of water (150 mL), the organic layer was separated, washed with brine (250 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to afford compound 2 (7.80 g, 91% yield) as a white solid with a melting point of 105-108 °C. 1H NMR (300 MHz, CDCl3) δ 7.63 (s, 2H).

References

[1] Tetrahedron Letters, 2001, vol. 42, # 5, p. 863 - 865
[2] Heterocycles, 2003, vol. 60, # 4, p. 879 - 886
[3] Journal of Organic Chemistry, 2003, vol. 68, # 21, p. 8075 - 8079
[4] Tetrahedron Letters, 2001, vol. 42, # 11, p. 2089 - 2092
[5] Russian Chemical Bulletin, 2014, vol. 63, # 2, p. 360 - 367

4-Iodopyrazole synthesis

288-13-1
3469-69-0
Synthesis of 4-Iodopyrazole from Pyrazole

4-Iodopyrazole Preparation Products And Raw materials

Raw materials

3,4-Diiodopyrazole 4-Bromopyrazole Pyrazole 1H-Pyrazol-4-ylamine Acetonitrile
iodine Ceric ammonium nitrate

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Preparation Products

4-Iodo-1-methyl-1H-pyrazole 1-Benzyl-1H-pyrazole 1-Benzyl-4-iodo-1H-pyrazole 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester 1-Butyl-4-iodo-1H-pyrazole
4-(2-(4-Iodo-1H-pyrazol-1-yl)ethyl)morpholine 1H-Pyrazole, 4-iodo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-

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4-Iodopyrazole Suppliers

Global Suppliers ( 478)
Supplier Tel Email Country ProdList Advantage
Nanjing YiFan Biological Technology Co., Ltd. 025-025-52700520 18914499889 sales@yfbiotech.com China 494 58
LEADMEDPHARM CO.,LTD 13674959855 13674959855 sales@synthontech.com China 3025 58
Changzhou Standard Chemicals Ltd. 0519-85607885 13776800733 email@standardschem.com China 118 62
Hubei Shishun Biotechnology Co. Ltd 027-59223025 15107168801 1718480011@qq.com China 9389 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Bridge Organics +1269-649-4200 ab@bridgeorganics.com United States 160 55
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Nanjing YiFan Biological Technology Co., Ltd. 58
LEADMEDPHARM CO.,LTD 58
Changzhou Standard Chemicals Ltd. 62
Hubei Shishun Biotechnology Co. Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Bridge Organics 55
future industrial shanghai co., ltd 65
Alfa Aesar 84

View Latest Price from 4-Iodopyrazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-iodopyrazole pictures 2026-09-02 4-iodopyrazole
3469-69-0
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-iodopyrazole pictures 2026-06-30 4-iodopyrazole
3469-69-0
 1KG 98% 1000KG Shaanxi Dideu New Materials Co. Ltd
4-Iodopyrazole pictures 2026-05-28 4-Iodopyrazole
3469-69-0
 $10.70 10kg 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
  • 4-Iodopyrazole pictures
  • 4-Iodopyrazole
    3469-69-0
  • $10.70
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD

4-Iodopyrazole Spectrum

4-Iodopyrazole(3469-69-0)MS4-Iodopyrazole(3469-69-0)1HNMR4-Iodopyrazole(3469-69-0)13CNMR4-Iodopyrazole(3469-69-0)IR14-Iodopyrazole(3469-69-0)IR24-Iodopyrazole(3469-69-0)Raman

3469-69-0 (4-Iodopyrazole) Related Search:

Pyrazole Pyraclostrobin Zolpidem tartrate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 3,4-Diiodopyrazole
1-ACETYL-4-IODO-1H-PYRAZOLE,acetyl-4-iodo-1H-pyrazole 3,5-DIMETHYL-4-IODO-1H-PYRAZOLE,3,5-DIMETHYL-4-IODOPYRAZOLE Zolpidem 1-Phenyl-4-iodopyrazole 3-Methyl-4-iodopyrazole
TERT-BUTYL 4-IODOPYRAZOLE-1-CARBOXYLATE,1-BOC-4-IODOPYRAZOLE,T-BUTYL 4-IODO-1H-PYRAZOLE-1-CARBOXYLATE 1-Benzyl-4-iodo-1H-pyrazole 4-Iodo-1,3,5-trimethyl-1H-pyrazole Iodoantipyrine 1H-Pyrazole, 4-iodo-1-(phenylmethoxy)-
5-Iodo-1H-pyrazole 4-Iodo-1-methyl-1H-pyrazole 4-Iodo-pyrazole-3-carboxylic acid

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4-IODOPYRAZOLE 1H-PYRAZOLE, 4-IODO- 4-Iodo-1H-pyrazole 99% Crizotinib Impurity 14 4-IODOPYRAZOLE 99% 4-Iodopyrazole ,98% 4-Lodophrazole 4-LODO PYRAZOLE 4-Iodopyrazole, 97+% 4-Iodopyrazole 4-Iodo-1H-pyrazole 4-iodopyrazole 4- 4-Iodopyrazole> 4-Iodopyrazole, 98%, for synthesis 4 - iodine pyrazole 4-IODO-1H-PYRAZOLE 4-iodopyrazol 3469-69-0 33469-69-0 3469-69-1 C3H3N2I C3H3IN2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrazoles HALOGEN Halides Pyrazoles & Triazoles Pyrazoles & Triazoles Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrazoles PyrazolesHeterocyclic Building Blocks Azoles blocks Iodides