1H-Pyrazol-4-ylamine
- CAS No.
- 28466-26-4
- Chemical Name:
- 1H-Pyrazol-4-ylamine
- Synonyms
- 1H-Pyrazol-4-amine;4-AMINOPYRAZOLE;4-AMINO-1H-PYRAZOLE;AKOS PAO-0001;H-PYRAZOL-4-YLAMINE;1H-Pyrazole-4-amine;4-Aminopyrazole 95%;1H-Pyrazol-4-ylamine;1H-Pyrazol-4-amine (9CI, ACI)
- CBNumber:
- CB1840324
- Molecular Formula:
- C3H5N3
- Molecular Weight:
- 83.09
- MDL Number:
- MFCD01693729
- MOL File:
- 28466-26-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 75-77°C |
|---|---|
| Boiling point | 142.17°C (rough estimate) |
| Density | 1.0248 (rough estimate) |
| refractive index | 1.5060 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | powder to crystal |
| pka | 17.70±0.50(Predicted) |
| color | White to Brown to Dark purple |
| Sensitive | Hygroscopic |
| InChI | InChI=1S/C3H5N3/c4-3-1-5-6-2-3/h1-2H,4H2,(H,5,6) |
| InChIKey | AXINVSXSGNSVLV-UHFFFAOYSA-N |
| SMILES | N1C=C(N)C=N1 |
| CAS DataBase Reference | 28466-26-4 |
| NIST Chemistry Reference | 4-NH2-pyrazole(28466-26-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ4993000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933199090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1H-Pyrazol-4-ylamine price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 700940 | 4-Aminopyrazole 95% | 28466-26-4 | 1g | $139 | 2026-04-30 | Buy |
| TCI Chemical | P2523 | 1H-Pyrazol-4-amine >98.0%(GC)(T) | 28466-26-4 | 1g | $65 | 2026-04-30 | Buy |
| Usbiological | 232754 | 4-Amino-1H-pyrazole ≥97% (GC) ≥97%(GC) | 28466-26-4 | 1g | $240 | 2026-06-03 | Buy |
| Usbiological | 232754 | 4-Amino-1H-pyrazole ≥97% (GC) ≥97%(GC) | 28466-26-4 | 5g | $531 | 2026-06-03 | Buy |
| Usbiological | 232754 | 4-Amino-1H-pyrazole ≥97% (GC) ≥97%(GC) | 28466-26-4 | 25g | $1727 | 2026-06-03 | Buy |
1H-Pyrazol-4-ylamine Chemical Properties,Uses,Production
Form
powder
Chemical Properties
It is white to brownish-purple solid under normal temperature and pressure, with certain alkalinity, and can form salts with various acids.
Uses
4-Aminopyrazole, is a versatile building block for the preparation of pharmaceutical and biologically active compounds. 4-Amino-1H-pyrazole, has also shown to have anticonvulsant activity, and thus can be used in the treatment of epileptic seizures.
Synthesis
2075-46-9
28466-26-4
4-Nitropyrazole (1.13 g, 10 mmol) was dissolved in methanol (10 mL) under hydrogen (1 atm) atmosphere and 10% Pd-C catalyst (0.1 g) was added. The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-aminopyrazole (860 mg, yield: 100%), which could be used in subsequent reactions without further purification.
References
[1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0252; 0253
[2] ChemMedChem, 2016, p. 1695 - 1699
[3] Patent: CN105418616, 2016, A. Location in patent: Paragraph 0118; 0119
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 3, p. 395 - 399
[5] Patent: WO2017/178510, 2017, A1. Location in patent: Page/Page column 297
1H-Pyrazol-4-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 1H-Pyrazol-4-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 1H-PYRAZOL-4-YLAMINE
28466-26-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | 1H-PYRAZOL-4-YLAMINE
28466-26-4
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 1H-PYRAZOL-4-YLAMINE
28466-26-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1H-PYRAZOL-4-YLAMINE
28466-26-4
- $1.00
- 98%
- Career Henan Chemical Co
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