BI 6901
- CAS No.
- 2040401-92-9
- Chemical Name:
- BI 6901
- Synonyms
- BI 6901;BI6901,BI 6901;1H-Indole-4-sulfonamide, N-[(1R)-3-(2-cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-
- CBNumber:
- CB04667627
- Molecular Formula:
- C23H27N5O3S
- Molecular Weight:
- 453.56
- MDL Number:
- MFCD34469257
- MOL File:
- 2040401-92-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
BI 6901 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066641 | BI-6901 99.76% | 2040401-92-9 | 5mg | $412 | 2026-06-04 | Buy |
| ChemScene | CS-0066641 | BI-6901 99.76% | 2040401-92-9 | 10mg | $650 | 2026-06-04 | Buy |
| ChemScene | CS-0066641 | BI-6901 99.76% | 2040401-92-9 | 25mg | $1246 | 2026-06-04 | Buy |
| ChemScene | CS-0066641 | BI-6901 99.76% | 2040401-92-9 | 50mg | $1950 | 2026-06-04 | Buy |
| ChemScene | CS-0066641 | BI-6901 99.76% | 2040401-92-9 | 100mg | $3087 | 2026-06-04 | Buy |
BI 6901 Chemical Properties, Uses, Production
Uses
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1].
Biological Activity
BI 6901 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research[1]. BI-6901 (intraperitoneal injection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1].
in vivo
BI-6901 (intraperitonealinjection; 100 mg/kg; bid.) exhibits a dose-dependent anti-inflammatory response against DNFB stimulated ear swelling in sensitized mice. The level of efficacy observed for BI-6901 is similar to that observed with anti-CCL27 antibody in the same model (60-85%)[1].
| Animal Model: | Balb-C mice with a DNFB model of contact hypersensitivity. |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitonealinjection |
| Result: | Had a inhibitory effect on the DNFB stimulated inflammatory response in sensitized Balb-c mice. |
storage
Store at -20°C
References
[1]. Asitha Abeywardane, et al. N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283.
BI 6901 Preparation Products And Raw materials
Raw materials
Preparation Products
BI 6901 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2896 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 1276242629@qq.com | China | 9977 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 4573 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Olix ( Hubei) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9769 | 58 |
