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VU 0409106

VU 0409106 Structure
VU 0409106 structure
CAS No.
1276617-62-9
Chemical Name:
VU 0409106
Synonyms
VU 0409106;3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide;Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-
CBNumber:
CB04726384
Molecular Formula:
C15H11FN4O2S
Molecular Weight:
330.34
MDL Number:
MOL File:
1276617-62-9.mol
Last updated:2025-04-17 18:22:24
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VU 0409106 Properties

Density 1.445±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 6.61±0.50(Predicted)
color White to off-white
FDA UNII J65UDU5WEA

VU 0409106 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 5322 VU0409106 ≥98%(HPLC) 1276617-62-9 10 $164 2021-12-16 Buy
TRC V787573 VU0409106 1276617-62-9 100mg $1080 2021-12-16 Buy
Product number Packaging Price Buy
5322 10 $164 Buy
V787573 100mg $1080 Buy

VU 0409106 Chemical Properties,Uses,Production

Uses

VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.

in vivo

VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].

Animal Model:CD-1 mice[1]
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mL?h)702
AUCbrain (ng/mL?h)696
B/P ratio0.99

IC 50

mGlu5: 24 nM (IC50)

VU 0409106 Preparation Products And Raw materials

Raw materials

Preparation Products

VU 0409106 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 994 55
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2959 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
BOC Sciences -- info@bocsci.com USA 0 65
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19965 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Shanghaizehan biopharma technology co., Ltd. 55
Shanghai Rechem science Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
TargetMol Chemicals Inc. 58

View Lastest Price from VU 0409106 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VU0409106 pictures 2024-10-24 VU0409106
1276617-62-9
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • VU0409106 pictures
  • VU0409106
    1276617-62-9
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.

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VU 0409106 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)- 1276617-62-9