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N-Acetyl-L-proline

N-Acetyl-L-proline Structure
N-Acetyl-L-proline structure
CAS No.
68-95-1
Chemical Name:
N-Acetyl-L-proline
Synonyms
AC-PRO-OH;NSC 280718;AC-PROLINE;N-AC-L-PRO;N-Ac-Pro-OH;Ac-L-Pro-Oh;N-Acetyl-Pro;AC-PYRD(2)-OH;Acetylproline;N-ACETYL-L-PRO
CBNumber:
CB0481658
Molecular Formula:
C7H11NO3
Molecular Weight:
157.17
MDL Number:
MFCD00020837
MOL File:
68-95-1.mol
MSDS File:
SDS
Last updated:2026-01-15 13:03:24
Product description Number Pack Size Price
N-Acetyl-L-proline A0783 1g $69
N-Acetyl-L-proline A0783 5g $140
Acetyl-L-proline 99+% 235177 5g $200
N-Acetyl-L-proline A187590 100g $475
N-Acetyl-L-proline FA10864 250g $935
More product size
Request For Quotation

N-Acetyl-L-proline Properties

Melting point 115-117 °C
alpha -86 º (c=1 EtOH)
Boiling point 366.2±35.0 °C(Predicted)
Density 1.274±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form Powder
pka 3.69±0.20(Predicted)
color White to off-white
BRN 83200
Cosmetics Ingredients Functions SKIN CONDITIONING - EMOLLIENT
Cosmetic Ingredient Review (CIR) N-Acetyl-L-proline (68-95-1)
InChI InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChIKey GNMSLDIYJOSUSW-LURJTMIESA-N
SMILES C(O)(=O)[C@@H]1CCCN1C(C)=O
CAS DataBase Reference 68-95-1(CAS DataBase Reference)
FDA UNII CC8XZ138VZ
NIST Chemistry Reference L-proline, 1-acetyl-(68-95-1)
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

N-Acetyl-L-proline price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A0783 N-Acetyl-L-proline 68-95-1 1g $69 2025-07-31 Buy
Sigma-Aldrich A0783 N-Acetyl-L-proline 68-95-1 5g $140 2023-06-20 Buy
Usbiological 235177 Acetyl-L-proline 99+% 68-95-1 5g $200 2021-12-16 Buy
TRC A187590 N-Acetyl-L-proline 68-95-1 100g $475 2021-12-16 Buy
Biosynth Carbosynth FA10864 N-Acetyl-L-proline 68-95-1 250g $935 2021-12-16 Buy
Product number Packaging Price Buy
A0783 1g $69 Buy
A0783 5g $140 Buy
235177 5g $200 Buy
A187590 100g $475 Buy
FA10864 250g $935 Buy

N-Acetyl-L-proline Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.

Definition

ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.

Biochem/physiol Actions

N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.

Synthesis

Acetic anhydride

108-24-7

L-Proline

147-85-3

N-Acetyl-L-proline

68-95-1

General procedure for the synthesis of N-acetyl-L-proline from L-proline and ethanoic anhydride: 115.1 mg (1 mmol) of L-proline was dissolved in an appropriate amount of methanol, followed by the addition of 0.3 ml (ca. 3 mmol) of ethanoic anhydride and 0.5 ml (ca. 3 mmol) of N,N-diisopropylethylamine (DIEA) to the reaction system. The reaction mixture was refluxed at 70°C for 7 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure and unreacted ethanoic anhydride was removed by freeze-drying. Finally, purification was carried out using high performance liquid chromatography (HPLC) (mobile phase methanol:water = 45:65 with 0.05% formic acid, detection wavelength 214 nm) to give a white solid product in 84.2% yield.

References

[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.

Description

N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However,  these methods may result in the production of many byproducts[1]. 

N-Acetyl-L-proline Preparation Products And Raw materials

Raw materials

Acetyl chloride Acetic anhydride L-Proline N,N-Diisopropylethylamine Methanol

Preparation Products

N-Acetyl-L-proline Suppliers

Global( 370)Suppliers
Supplier Tel Email Country ProdList Advantage
DONBOO AMINO ACID COMPANY
+8618051385538 donboo@donboo.com China 9363 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Hebei Zhuanglai Chemical Trading Co Ltd 		+86-16264648883 niki@zlchemi.com China 7245 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13799 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 340 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Supplier Advantage
DONBOO AMINO ACID COMPANY
58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58

View Lastest Price from N-Acetyl-L-proline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-L-proline pictures 2026-02-10 N-Acetyl-L-proline
68-95-1
 US $1.00 / g 100g 98% 200kg/month WUHAN FORTUNA CHEMICAL CO., LTD
N-acetyl-L-proline pictures 2025-09-25 N-acetyl-L-proline
68-95-1
 US $200.00-1.00 / KG 1KG 99%, 99.5% Sublimated g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
N-Acetyl-L-proline pictures 2025-05-23 N-Acetyl-L-proline
68-95-1
 US $45.00 / kg 1kg 99% 20 tons Hebei Zhuanglai Chemical Trading Co Ltd
  • N-acetyl-L-proline pictures
  • N-acetyl-L-proline
    68-95-1
  • US $200.00-1.00 / KG
  • 99%, 99.5% Sublimated
  • Henan Fengda Chemical Co., Ltd

N-Acetyl-L-proline Spectrum

N-Acetyl-L-proline(68-95-1)1HNMR

68-95-1(N-Acetyl-L-proline)Related Search:

L-Proline cis-4-Hydroxy-L-proline Acetylacetone Acetyl chloride D-Proline
L-PROLINE-(4-3H(N)) N-Acetyl-L-valine AC-TYR-NH2 N-Acetyl-L-cysteine N-ALPHA-ACETYL-D-PROLINE,N-ACETYL-D-PROLINE,ACETYL-D-PROLINE
Fosinopril sodium 4β-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline,(4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline Disodium Salt Fosinopril N-ALPHA-ACETYL-L-PROLINE AMIDE,ACETYL-L-PROLINE AMIDE N6-Trifluoroacetyl-L-lysyl-L-proline
1-ACETYLPYRROLIDINE (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenyl-d5-butyl)phosphinyl]acetyl]-L-proline Sodium Salt 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-proline tert-Butyl Ester,7-Methoxycoumarin-4-Acetyl-L-proline tert-Butyl Ester

1of4

N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline (2S)-1-acetyl-2-pyrrolidinecarboxylate (S)-N-Acetylproline L-N-Acetylproline NSC 280718 N-Ac-Pro-OH ASINEX-REAG BAS 16579166 ACETYL-L-PROLINE AC-PYRD(2)-OH AC-PROLINE AC-PRO-OH N-ALPHA-ACETYL-L-PROLINE N-ALPHA-ACETYL-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ACETYL-L-PRO N-ACETYL-L-PROLINE N-AC-L-PRO (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID 1-Acetylproline Acetylproline L-Proline, 1-acetyl- Proline, 1-acetyl-, L- 1-acetyl-L-proline Ac-L-Pro-Oh L-Proline, 1-acetyl- (9CI) (S)-Acetyl-pyrrolidine-2-carboxylic acid Acetyl-L-proline99% N-ACETYL-L-PROLINE (N-AC-L-PRO) N-alpha-Actetyl-L-proline N-Acethyl-L-proline (+/-)-(3-Methoxy-4-hydroxyphenyl)-2-isopropylaminoethanol hydrochloride Benzenemethanol, 4-hydroxy-3-methoxy-a-[[(1-methylethyl)amino]methyl]-, hydrochloride Vanillyl alcohol, a-[(isopropylamino)methyl]-, hydrochloride (2S)-1-Acetylpyrrolidine-2α-carboxylic acid N-Acetyl-L-proline,99% N-ACETYL-L-PROLINE (USP) Ac-Pro-OH ,≥99% (S)-(-)-N-Acetylproline N-Acetyl-L-proline, 99% 1GR l-proline n-acetyl N-Acetyl-L-proline USP/EP/BP N-Acetyl-L-Proline extrapure, 98% N-Acetyl-Pro N-Acetyl-L-proline N-Acetyl-L-proline, 95% 68-95-1 C7H10NO3 CARBOXYLIC ACID Modified Amino Acids Biochemicals and Reagents BioChemical A - H Amino Acids and Peptides A - H Amino Acids Modified Amino Acids Amino Acid Derivatives Amino Acids chiral