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N-Acetyl-L-proline

N-Acetyl-L-proline structure

CAS No.: 68-95-1

Chemical Name:: N-Acetyl-L-proline

Synonyms: AC-PRO-OH;Acetylproline;1-Acetylproline;N-Ac-Pro-OH;ACETYL-L-PROLINE;L-N-Acetylproline;NSC 280718;AC-PROLINE;N-AC-L-PRO;Ac-L-Pro-Oh

CBNumber:: CB0481658

Molecular Formula:: C7H11NO3

Molecular Weight:: 157.17

MDL Number:: MFCD00020837

MOL File:: 68-95-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:43:12

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N-Acetyl-L-proline Properties

Melting point	115-117 °C
alpha	-86 º (c=1 EtOH)
Boiling point	366.2±35.0 °C(Predicted)
Density	1.274±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form	Powder
pka	3.69±0.20(Predicted)
color	White to off-white
BRN	83200
Cosmetics Ingredients Functions	SKIN CONDITIONING - EMOLLIENT
Cosmetic Ingredient Review (CIR)	N-Acetyl-L-proline (68-95-1)
InChI	InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChIKey	GNMSLDIYJOSUSW-LURJTMIESA-N
SMILES	C(O)(=O)[C@@H]1CCCN1C(C)=O
CAS DataBase Reference	68-95-1(CAS DataBase Reference)
FDA UNII	CC8XZ138VZ
NIST Chemistry Reference	L-proline, 1-acetyl-(68-95-1)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Acetyl-L-proline price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A0783	N-Acetyl-L-proline	68-95-1	1g	$69	2025-07-31	Buy
Sigma-Aldrich	A0783	N-Acetyl-L-proline	68-95-1	5g	$140	2023-06-20	Buy
Usbiological	235177	Acetyl-L-proline 99+% ≥99%		5g	$200	2026-06-03	Buy
Usbiological	235177	Acetyl-L-proline 99+% ≥99%		25g	$333	2026-06-03	Buy
Usbiological	235177	Acetyl-L-proline 99+% ≥99%		100g	$645	2026-06-03	Buy

Product number	Packaging	Price	Buy
A0783	1g	$69	Buy
A0783	5g	$140	Buy
235177	5g	$200	Buy
235177	25g	$333	Buy
235177	100g	$645	Buy

N-Acetyl-L-proline Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.

Definition

ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.

Biochem/physiol Actions

N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.

Synthesis

108-24-7

147-85-3

68-95-1

General procedure for the synthesis of N-acetyl-L-proline from L-proline and ethanoic anhydride: 115.1 mg (1 mmol) of L-proline was dissolved in an appropriate amount of methanol, followed by the addition of 0.3 ml (ca. 3 mmol) of ethanoic anhydride and 0.5 ml (ca. 3 mmol) of N,N-diisopropylethylamine (DIEA) to the reaction system. The reaction mixture was refluxed at 70°C for 7 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure and unreacted ethanoic anhydride was removed by freeze-drying. Finally, purification was carried out using high performance liquid chromatography (HPLC) (mobile phase methanol:water = 45:65 with 0.05% formic acid, detection wavelength 214 nm) to give a white solid product in 84.2% yield.

References

[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.

Description

N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However, these methods may result in the production of many byproducts[1].

N-Acetyl-L-proline Preparation Products And Raw materials

Raw materials

Acetyl chloride Acetic anhydride L-Proline N,N-Diisopropylethylamine Methanol

Preparation Products

N-Acetyl-L-proline Suppliers

Global( 377)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuxi maimo topp biotechnology co., LTD	15061806929	linda-fu@mimotopes.cn	China	5795	58
Shanghai Kanglang Biotechnology Co., Ltd.	021-61998208 18217752821;	sales@klbio.cn	China	9619	58
Tangshan Jinyuan Biotechnology Co., Ltd	15222523250	446750422@qq.com	China	299	58
Wuhan Roche Technology Development Co., Ltd.,	18986168071; 18986168071	18986168071@163.com	China	95	55
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56

Supplier	Advantage
Wuxi maimo topp biotechnology co., LTD	58
Shanghai Kanglang Biotechnology Co., Ltd.	58
Tangshan Jinyuan Biotechnology Co., Ltd	58
Wuhan Roche Technology Development Co., Ltd.,	55
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
Ark Pharm, Inc.	56

View Lastest Price from N-Acetyl-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	N-Acetyl-L-proline 68-95-1	$1.00	100g	98%	200kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	N-acetyl-L-proline 68-95-1	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2025-05-23	N-Acetyl-L-proline 68-95-1	$45.00	1kg	99%	20 tons	Hebei Zhuanglai Chemical Trading Co Ltd

N-Acetyl-L-proline
68-95-1
$1.00
98%
WUHAN FORTUNA CHEMICAL CO., LTD

N-acetyl-L-proline
68-95-1
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

N-Acetyl-L-proline
68-95-1
$45.00
99%
Hebei Zhuanglai Chemical Trading Co Ltd

N-Acetyl-L-proline Spectrum

N-Acetyl-L-proline(68-95-1)¹HNMR

68-95-1(N-Acetyl-L-proline)Related Search:

Acetylacetone Acetyl chloride D-Proline L-Proline cis-4-Hydroxy-L-proline

N-Acetyl-L-valine N-Acetyl-L-cysteine Ac-Tyr-NH2 L-Proline-(4-3H(n)) N-ALPHA-ACETYL-D-PROLINE,N-ACETYL-D-PROLINE,ACETYL-D-PROLINE

Fosinopril sodium 4β-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline,(4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline Disodium Salt Fosinopril N-ALPHA-ACETYL-L-PROLINE AMIDE,ACETYL-L-PROLINE AMIDE N6-Trifluoroacetyl-L-lysyl-L-proline

1-ACETYLPYRROLIDINE (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenyl-d5-butyl)phosphinyl]acetyl]-L-proline Sodium Salt 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-proline tert-Butyl Ester,7-Methoxycoumarin-4-Acetyl-L-proline tert-Butyl Ester

1of4

N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline (2S)-1-acetyl-2-pyrrolidinecarboxylate (S)-N-Acetylproline NSC 280718 ASINEX-REAG BAS 16579166 AC-PYRD(2)-OH AC-PROLINE N-ALPHA-ACETYL-L-PROLINE N-ALPHA-ACETYL-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ACETYL-L-PRO N-ACETYL-L-PROLINE N-AC-L-PRO (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID L-Proline, 1-acetyl- Proline, 1-acetyl-, L- 1-acetyl-L-proline Ac-L-Pro-Oh L-Proline, 1-acetyl- (9CI) (S)-Acetyl-pyrrolidine-2-carboxylic acid Acetyl-L-proline99% N-ACETYL-L-PROLINE (N-AC-L-PRO) N-alpha-Actetyl-L-proline N-Acethyl-L-proline (+/-)-(3-Methoxy-4-hydroxyphenyl)-2-isopropylaminoethanol hydrochloride Benzenemethanol, 4-hydroxy-3-methoxy-a-[[(1-methylethyl)amino]methyl]-, hydrochloride Vanillyl alcohol, a-[(isopropylamino)methyl]-, hydrochloride (2S)-1-Acetylpyrrolidine-2α-carboxylic acid N-Acetyl-L-proline,99% N-ACETYL-L-PROLINE (USP) Ac-Pro-OH ,≥99% (S)-(-)-N-Acetylproline N-Acetyl-L-proline, 99% 1GR l-proline n-acetyl N-Acetyl-L-proline USP/EP/BP N-Acetyl-L-Proline extrapure, 98% N-Acetyl-Pro N-Acetyl-L-proline N-Acetyl-L-proline, 95% ACETYL-L-PROLINE 1-Acetylproline AC-PRO-OH Acetylproline L-N-Acetylproline N-Ac-Pro-OH 68-95-1 C7H10NO3 CARBOXYLIC ACID Modified Amino Acids Biochemicals and Reagents BioChemical A - H Amino Acids and Peptides A - H Amino Acids Modified Amino Acids Amino Acid Derivatives Amino Acids chiral