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N-Acetyl-L-valine

N-Acetyl-L-valine structure

CAS No.: 96-81-1

Chemical Name:: N-Acetyl-L-valine

Synonyms: AC-VAL-OH;ACETYL-L-VALINE;Ac-L-Val-OH;Acetylvaline;AC-VALINE;Ac-Veu-OH;N-Ac-L-Val-OH;N-ACETYL-L-VALINE;L-Valine, N-acetyl-;N-α-Actetyl-L-valine

CBNumber:: CB5716614

Molecular Formula:: C7H13NO3

Molecular Weight:: 159.18

MDL Number:: MFCD00066066

MOL File:: 96-81-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:04:09

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N-Acetyl-L-valine Properties

Melting point	163-167℃
alpha	[α]D20 -16～-20゜ (c=5, C2H5OH)
Boiling point	362.2±25.0 °C(Predicted)
Density	1.094±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	soluble in Methanol
form	Crystalline Powder
pka	3.62±0.10(Predicted)
color	White
optical activity	-18° (C=0.01 g/ml, H2O)
Major Application	peptide synthesis
InChI	InChI=1S/C7H13NO3/c1-4(2)6(7(10)11)8-5(3)9/h4,6H,1-3H3,(H,8,9)(H,10,11)/t6-/m0/s1
InChIKey	IHYJTAOFMMMOPX-LURJTMIESA-N
SMILES	C(O)(=O)[C@H](C(C)C)NC(C)=O
CAS DataBase Reference	96-81-1(CAS DataBase Reference)
FDA UNII	U83P7H9HV3
NIST Chemistry Reference	L-valine, n-acetyl-(96-81-1)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
Hazard Codes	Xi
Risk Statements	36-43
Safety Statements	26-36/37
WGK Germany	3
HS Code	2922498590
Storage Class	11 - Combustible Solids

N-Acetyl-L-valine price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	806463	N-Acetyl-L-valine	96-81-1	250mg	$40.5	2024-03-01	Buy
TCI Chemical	A2366	N-Acetyl-L-valine >98.0%(HPLC)(T)	96-81-1	5g	$23	2026-04-30	Buy
TCI Chemical	A2366	N-Acetyl-L-valine >98.0%(HPLC)(T)	96-81-1	25g	$48	2026-04-30	Buy
Usbiological	260558	Acetyl-L-valine Asreported	96-81-1	25g	$347	2026-06-03	Buy
Usbiological	260558	Acetyl-L-valine Asreported	96-81-1	50g	$516	2026-06-03	Buy

Product number	Packaging	Price	Buy
806463	250mg	$40.5	Buy
A2366	5g	$23	Buy
A2366	25g	$48	Buy
260558	25g	$347	Buy
260558	50g	$516	Buy

N-Acetyl-L-valine Chemical Properties, Uses, Production

Chemical Properties

White crystalline powder

Uses

Ac-Val-OH may be employed as a ligand for the meta-selective tert-alkylation reaction.

Definition

ChEBI: An L-valine derivative in which one of the amino hydrogens of L-valine has been replaced by an acetyl group.

General Description

Ac-Val-OH is an N-protected valine amino acid ligand. It participates in the 2,6-diolefination reaction of phenylacetic acids.

Synthesis

72-18-4

108-24-7

96-81-1

The general procedure for the synthesis of N-acetyl-L-valine from L-valine and acetic anhydride was as follows: L-valine (200 g, 1.7 mol) was dissolved in distilled water (500 mL), followed by the addition of 30% sodium hydroxide solution (170 mL). After cooling the reaction mixture to 0-5°C, acetic anhydride (32 mL, 1.4 eq.) was added slowly and dropwise. This was repeated six times (total acetic anhydride: 6 x 32 mL; 30% sodium hydroxide solution: 6 x 34 mL) by alternating dropwise additions of 30% sodium hydroxide solution (34 mL) and acetic anhydride (32 mL) while maintaining the temperature at 0-5°C. After the addition was completed, the reaction mixture continued to be stirred at 0°C for 2 hours. Subsequently, 32% hydrochloric acid (380 mL) was slowly added to adjust the pH to below 3 while maintaining the reaction temperature at 0°C. The resulting slurry was allowed to crystallize for 12 h. The solid product was collected by filtration and the filter cake was washed with 0.1 N hydrochloric acid (100 mL). Finally, the wet N-acetyl-L-valine was dried to give 233 g of white crystalline solid in 86% yield.

IC 50

Human Endogenous Metabolite

References

[1] New Journal of Chemistry, 2002, vol. 26, # 7, p. 834 - 843
[2] Synthetic Communications, 1992, vol. 22, # 2, p. 257 - 264
[3] Patent: WO2005/40097, 2005, A1. Location in patent: Page/Page column 9
[4] Journal of the American Chemical Society, 2011, vol. 133, # 43, p. 17176 - 17179
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 4636,4642

N-Acetyl-L-valine Preparation Products And Raw materials

Raw materials

L-Valine Crotonic acid, 2-acetamido-3-methyl- Acetic anhydride Sodium hydroxide Hydrochloric acid

Preparation Products

N-Acetyl-L-valine Suppliers

Global Suppliers ( 311)

Supplier	Tel	Email	Country	ProdList	Advantage
LEADMEDPHARM CO.,LTD	13674959855 13674959855	sales@synthontech.com	China	3025	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60

Supplier	Advantage
LEADMEDPHARM CO.,LTD	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60

View Latest Price from N-Acetyl-L-valine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	N-Acetyl-L-valine 96-81-1		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	N-Acetyl-L-valine 96-81-1	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	N-Acetyl-L-valine 96-81-1	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

N-Acetyl-L-valine
96-81-1
98%
Henan Aochuang Chemical Co.,Ltd.

N-Acetyl-L-valine
96-81-1
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Acetyl-L-valine
96-81-1
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Acetyl-L-valine Spectrum

N-Acetyl-L-valine(96-81-1)MS N-Acetyl-L-valine(96-81-1)¹HNMR

96-81-1 (N-Acetyl-L-valine) Related Search:

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L-Valine Acetylacetone N-Acetylneuraminic acid N-Acetyl-L-proline N-Acetyl-L-cysteine

Acetylcholine Ac-Tyr-NH2 N-Acetyl-L-asparagine 2-Acetylaminopropionic acid N-Acetyl-L-isoleucine

N-Acetyl-L-tryptophan N-Acetyl-D-phenylalanine 2-Acetylamino-propionic acid

1of4

N-alpha-Actetyl-L-valine (S)-2-ACETAMIDO-3-METHYLBUTANOIC ACID N-ACETYL-L-VALINE extrapure for biochemistry (2S)-2-acetamido-3-methylbutanoic acid (2S)-2-acetamido-3-methyl-butanoic acid (2S)-2-acetamido-3-methyl-butyric acid L-Valine, N-acetyl-Valine, N-acetyl-, L-Ac-L-Val-OH N-α-Actetyl-L-valine N-Ac-L-Val-OH Acetyl-L-valine≥ 98% (Assay) L-Valine, N-acetyl- Valine, N-acetyl-, L- AC-VALINE N-Acetyl-L-valine N-ALPHA-ACETYL-L-VALINE N-ACETYL-L-VALINE N-Acetyl-L-valine > N-Acetyl-L-valine,98% N-Acetyl-L-valine USP/EP/BP N-Acetyl-L-Valine extrapure, 99% Ac-Veu-OH N -Acety1- L - leucine Acetylvaline AC-VAL-OH ACETYL-L-VALINE Ac-L-Val-OH 96-81-1 96-81-8 amino amino acid Amino Acids Amino Acid Derivatives