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N-Acetyl-L-valine

N-Acetyl-L-valine Structure
N-Acetyl-L-valine structure
CAS No.
96-81-1
Chemical Name:
N-Acetyl-L-valine
Synonyms
AC-VAL-OH;AC-VALINE;Ac-Veu-OH;Ac-L-Val-OH;Acetylvaline;N-Ac-L-Val-OH;ACETYL-L-VALINE;N-ACETYL-L-VALINE;L-Valine, N-acetyl-;N-α-Actetyl-L-valine
CBNumber:
CB5716614
Molecular Formula:
C7H13NO3
Molecular Weight:
159.18
MDL Number:
MFCD00066066
MOL File:
96-81-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:54
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N-Acetyl-L-valine Properties

Melting point 163-167℃
alpha [α]D20 -16～-20゜ (c=5, C2H5OH)
Boiling point 362.2±25.0 °C(Predicted)
Density 1.094±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility soluble in Methanol
form Crystalline Powder
pka 3.62±0.10(Predicted)
color White
optical activity -18° (C=0.01 g/ml, H2O)
InChI InChI=1S/C7H13NO3/c1-4(2)6(7(10)11)8-5(3)9/h4,6H,1-3H3,(H,8,9)(H,10,11)/t6-/m0/s1
InChIKey IHYJTAOFMMMOPX-LURJTMIESA-N
SMILES C(O)(=O)[C@H](C(C)C)NC(C)=O
CAS DataBase Reference 96-81-1(CAS DataBase Reference)
FDA UNII U83P7H9HV3
NIST Chemistry Reference L-valine, n-acetyl-(96-81-1)
UNSPSC Code 12352116
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  26-36/37
WGK Germany  3
HS Code  2922498590

N-Acetyl-L-valine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 806463 N-Acetyl-L-valine 96-81-1 250mg $40.5 2024-03-01 Buy
TCI Chemical A2366 N-Acetyl-L-valine >98.0%(HPLC)(T) 96-81-1 5g $20 2025-07-31 Buy
TCI Chemical A2366 N-Acetyl-L-valine >98.0%(HPLC)(T) 96-81-1 25g $46 2025-07-31 Buy
TRC A192393 N-Acetyl-L-valine 96-81-1 100mg $60 2021-12-16 Buy
Usbiological 260558 Acetyl-L-valine 96-81-1 25g $347 2021-12-16 Buy
Product number Packaging Price Buy
806463 250mg $40.5 Buy
A2366 5g $20 Buy
A2366 25g $46 Buy
A192393 100mg $60 Buy
260558 25g $347 Buy

N-Acetyl-L-valine Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

Ac-Val-OH may be employed as a ligand for the meta-selective tert-alkylation reaction.

Definition

ChEBI: An L-valine derivative in which one of the amino hydrogens of L-valine has been replaced by an acetyl group.

General Description

Ac-Val-OH is an N-protected valine amino acid ligand. It participates in the 2,6-diolefination reaction of phenylacetic acids.

Synthesis

L-Valine

72-18-4

Acetic anhydride

108-24-7

N-Acetyl-L-valine

96-81-1

The general procedure for the synthesis of N-acetyl-L-valine from L-valine and acetic anhydride was as follows: L-valine (200 g, 1.7 mol) was dissolved in distilled water (500 mL), followed by the addition of 30% sodium hydroxide solution (170 mL). After cooling the reaction mixture to 0-5°C, acetic anhydride (32 mL, 1.4 eq.) was added slowly and dropwise. This was repeated six times (total acetic anhydride: 6 x 32 mL; 30% sodium hydroxide solution: 6 x 34 mL) by alternating dropwise additions of 30% sodium hydroxide solution (34 mL) and acetic anhydride (32 mL) while maintaining the temperature at 0-5°C. After the addition was completed, the reaction mixture continued to be stirred at 0°C for 2 hours. Subsequently, 32% hydrochloric acid (380 mL) was slowly added to adjust the pH to below 3 while maintaining the reaction temperature at 0°C. The resulting slurry was allowed to crystallize for 12 h. The solid product was collected by filtration and the filter cake was washed with 0.1 N hydrochloric acid (100 mL). Finally, the wet N-acetyl-L-valine was dried to give 233 g of white crystalline solid in 86% yield.

IC 50

Human Endogenous Metabolite

References

[1] New Journal of Chemistry, 2002, vol. 26, # 7, p. 834 - 843
[2] Synthetic Communications, 1992, vol. 22, # 2, p. 257 - 264
[3] Patent: WO2005/40097, 2005, A1. Location in patent: Page/Page column 9
[4] Journal of the American Chemical Society, 2011, vol. 133, # 43, p. 17176 - 17179
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 4636,4642

N-Acetyl-L-valine Preparation Products And Raw materials

Raw materials

L-Valine Crotonic acid, 2-acetamido-3-methyl- Acetic anhydride Sodium hydroxide Hydrochloric acid

Preparation Products

N-Acetyl-L-valine Suppliers

Global( 305)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 sales@hbmojin.com China 12285 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 340 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Sichuan Jiaying Lai Technology Co.,LTD 		18716376478 ycling@enlaibio.com CHINA 302 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211 info@longyupharma.com China 2557 58
Supplier Advantage
Hebei Mujin Biotechnology Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Anqing Chico Pharmaceutical Co., Ltd. 		58
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58
Sichuan Jiaying Lai Technology Co.,LTD 		58
BOC Sciences 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58

View Lastest Price from N-Acetyl-L-valine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-L-valine pictures 2025-08-08 N-Acetyl-L-valine
96-81-1
 US $0.00 / KG 1KG 99.5% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
N-Acetyl-L-valine pictures 2025-04-04 N-Acetyl-L-valine
96-81-1
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
N-Acetyl-L-valine pictures 2021-07-13 N-Acetyl-L-valine
96-81-1
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • N-Acetyl-L-valine pictures
  • N-Acetyl-L-valine
    96-81-1
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

N-Acetyl-L-valine Spectrum

N-Acetyl-L-valine(96-81-1)MSN-Acetyl-L-valine(96-81-1)1HNMR

96-81-1(N-Acetyl-L-valine)Related Search:

Acetylspiramycin Acetylcholine Acetylsalicylic acid Valine Acetaminophen
N-Acetyl-L-cysteine Acetyl chloride Acetylacetone L-Valine N-Acetyl-L-proline
AC-TYR-NH2 N-Acetylneuraminic acid N-Acetyl-L-tryptophan N-Acetyl-L-isoleucine 2-Acetylaminopropionic acid
N-Acetyl-L-asparagine N-ACETYL-D-PHENYLALANINE 2-Acetylamino-propionic acid

1of4

Ac-L-Val-OH N-alpha-Actetyl-L-valine (S)-2-ACETAMIDO-3-METHYLBUTANOIC ACID N-ACETYL-L-VALINE extrapure for biochemistry (2S)-2-acetamido-3-methylbutanoic acid (2S)-2-acetamido-3-methyl-butanoic acid (2S)-2-acetamido-3-methyl-butyric acid L-Valine, N-acetyl-Valine, N-acetyl-, L-Ac-L-Val-OH N-α-Actetyl-L-valine N-Ac-L-Val-OH Acetyl-L-valine≥ 98% (Assay) Acetylvaline L-Valine, N-acetyl- Valine, N-acetyl-, L- AC-VAL-OH AC-VALINE ACETYL-L-VALINE N-Acetyl-L-valine N-ALPHA-ACETYL-L-VALINE N-ACETYL-L-VALINE N-Acetyl-L-valine > N-Acetyl-L-valine,98% N-Acetyl-L-valine USP/EP/BP N-Acetyl-L-Valine extrapure, 99% Ac-Veu-OH N -Acety1- L - leucine 96-81-1 96-81-8 amino amino acid Amino Acids Amino Acid Derivatives