D-Proline
- CAS No.
- 344-25-2
- Chemical Name:
- D-Proline
- Synonyms
- Proline;D-PRO;H-D-PRO-OH;D-Pro-OH;(R)-PYRROLIDINE-2-CARBOXYLIC ACID;(2R)-Pyrrolidine-2-carboxylic acid;D-PYRROLIDINE-2-CARBOXYLIC ACID;D-PyrroL;D-PROLINE;D(+)-PROLINE
- CBNumber:
- CB2754303
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00064317
- MOL File:
- 344-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| D-Proline ReagentPlus , ≥99% | 858919 | 500mg | $51.2 |
| D-Proline ReagentPlus , ≥99% | 858919 | 5g | $126 |
| D-Proline >98.0%(T) | P0994 | 5g | $72 |
| D-Proline >98.0%(T) | P0994 | 25g | $230 |
| D-PROLINE 98% | 69586 | 25G | $11 |
| More product size | |||
| Melting point | 223 °C (dec.) (lit.) |
|---|---|
| alpha | 84.75 º (c=4, H2O) |
| Boiling point | 215.41°C (rough estimate) |
| Density | 1.36 |
| refractive index | 85 ° (C=4, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Sparingly) |
| pka | 1.952(at 25℃) |
| form | Powder |
| color | White to yellow to pale brown |
| optical activity | [α]22/D +85.0°, c = 4 in H2O |
| Water Solubility | soluble >1000 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| BRN | 80811 |
| InChI | 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1 |
| InChIKey | ONIBWKKTOPOVIA-SCSAIBSYSA-N |
| SMILES | OC(=O)[C@H]1CCCN1 |
| LogP | -0.060 (est) |
| FDA 21 CFR | 582.5650 |
| CAS DataBase Reference | 344-25-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | L01Q4LGZ5L |
| EPA Substance Registry System | D-Proline (344-25-2) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
D-Proline price More Price(78)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 858919 | D-Proline ReagentPlus , ≥99% | 344-25-2 | 500mg | $51.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 858919 | D-Proline ReagentPlus , ≥99% | 344-25-2 | 5g | $126 | 2026-04-30 | Buy |
| TCI Chemical | P0994 | D-Proline >98.0%(T) | 344-25-2 | 5g | $72 | 2026-04-30 | Buy |
| TCI Chemical | P0994 | D-Proline >98.0%(T) | 344-25-2 | 25g | $230 | 2026-04-30 | Buy |
| AstaTech | 69586 | D-PROLINE 98% | 344-25-2 | 25G | $11 | 2026-04-30 | Buy |
D-Proline Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Occurrence
D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity.
Uses
proline is a skin-conditioning agent. An amino acid found in the collagen molecule.
Uses
Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.
Uses
Labelled D-Proline Lasubine II and (+)-Cermizine C.
Definition
ChEBI: D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 2818, 1949 DOI: 10.1021/ja01176a065
Tetrahedron Letters, 28, p. 6469, 1987 DOI: 10.1016/S0040-4039(00)96890-4
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
D-amino acids are an important class of chiral reagents and chiral intermediates. Currently, most of the D-amino acids are produced by synthesizing the racemates and then splitting them to obtain the optical isomers. The asymmetric conversion method, using (2 R,3R)-tartaric acid as the splitting agent and in the presence of butyraldehyde, allowed the simultaneous reaction of the racemization of L-proline and the salt crystallization of D-proline with (2 R,3R)-tartaric acid. The total yield was 82 %.
D-Proline Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Maanshan Tiantai Biotechnology Co., Ltd. | +86-0555-8889890 +86-17356584060 | GM@tiantaibio-tech.com | China | 72 | 58 |
| Huzhou Chenxi Environmental Protection Technology Co. , Ltd. | +8616762203950 | 1034385273@qq.com | China | 55 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5981 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5233 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
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View Lastest Price from D-Proline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-22 | D-Proline
344-25-2
|
US $0.00 / kg | 1kg | 98% | 20t | Hubei Lidu New Material Technology Co., Ltd | |
 |
2026-05-22 | D-Proline
344-25-2
|
US $0.00-0.00 / kg | 1kg | 98.5%-101% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-05-11 | (R)-pyrrolidine-2-carboxylic acid
344-25-2
|
US $29.00 / mL | 99.98% | 10g | TargetMol Chemicals Inc. |
-
- D-Proline
344-25-2
- US $0.00 / kg
- 98%
- Hubei Lidu New Material Technology Co., Ltd
-
- D-Proline
344-25-2
- US $0.00-0.00 / kg
- 98.5%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- (R)-pyrrolidine-2-carboxylic acid
344-25-2
- US $29.00 / mL
- 99.98%
- TargetMol Chemicals Inc.
