D-Proline
- CAS No.
- 344-25-2
- Chemical Name:
- D-Proline
- Synonyms
- Proline;D-PRO;H-D-PRO-OH;D-Pro-OH;(R)-PYRROLIDINE-2-CARBOXYLIC ACID;(2R)-Pyrrolidine-2-carboxylic acid;D-PYRROLIDINE-2-CARBOXYLIC ACID;D-PyrroL;D-PROLINE;D(+)-PROLINE
- CBNumber:
- CB2754303
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00064317
- MOL File:
- 344-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 223 °C (dec.) (lit.) |
|---|---|
| alpha | 84.75 º (c=4, H2O) |
| Boiling point | 215.41°C (rough estimate) |
| Density | 1.36 |
| refractive index | 85 ° (C=4, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Sparingly) |
| pka | 1.952(at 25℃) |
| form | Powder |
| color | White to yellow to pale brown |
| optical activity | [α]22/D +85.0°, c = 4 in H2O |
| Water Solubility | soluble >1000 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| BRN | 80811 |
| InChI | 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1 |
| InChIKey | ONIBWKKTOPOVIA-SCSAIBSYSA-N |
| SMILES | OC(=O)[C@H]1CCCN1 |
| LogP | -0.060 (est) |
| CAS DataBase Reference | 344-25-2(CAS DataBase Reference) |
| FDA 21 CFR | 582.5650 |
| EWG's Food Scores | 1 |
| FDA UNII | L01Q4LGZ5L |
| EPA Substance Registry System | D-Proline (344-25-2) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
D-Proline price More Price(122)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 858919 | D-Proline ReagentPlus , ≥99% | 344-25-2 | 500mg | $51.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 858919 | D-Proline ReagentPlus , ≥99% | 344-25-2 | 5g | $126 | 2026-04-30 | Buy |
| TCI Chemical | P0994 | D-Proline >98.0%(T) | 344-25-2 | 5g | $72 | 2026-04-30 | Buy |
| TCI Chemical | P0994 | D-Proline >98.0%(T) | 344-25-2 | 25g | $230 | 2026-04-30 | Buy |
| Usbiological | P9010-10 | D-Proline, 99.9+% | 344-25-2 | 5g | $96 | 2026-06-04 | Buy |
D-Proline Chemical Properties,Uses,Production
Chemical Properties
White to off-white powder
Occurrence
D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva. These amino acids may be of bacterial origin, but there is also evidence that they are endogenously produced through amino acid racemase activity.
Uses
proline is a skin-conditioning agent. An amino acid found in the collagen molecule.
Uses
Used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.
Uses
Labelled D-Proline Lasubine II and (+)-Cermizine C.
Definition
ChEBI: D-proline is the D-enantiomer of proline. It has a role as a mouse metabolite. It is a D-alpha-amino acid and a proline. It is a conjugate base of a D-prolinium. It is a conjugate acid of a D-prolinate. It is an enantiomer of a L-proline. It is a tautomer of a D-proline zwitterion.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 2818, 1949 DOI: 10.1021/ja01176a065
Tetrahedron Letters, 28, p. 6469, 1987 DOI: 10.1016/S0040-4039(00)96890-4
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
D-amino acids are an important class of chiral reagents and chiral intermediates. Currently, most of the D-amino acids are produced by synthesizing the racemates and then splitting them to obtain the optical isomers. The asymmetric conversion method, using (2 R,3R)-tartaric acid as the splitting agent and in the presence of butyraldehyde, allowed the simultaneous reaction of the racemization of L-proline and the salt crystallization of D-proline with (2 R,3R)-tartaric acid. The total yield was 82 %.
D-Proline Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Organic Bio-Tech (Suzhou) Co.,Ltd | 18061997750 | info@organic-Biotechnology.com | China | 192 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuxi Bikang Bioengineering Co., Ltd | 0510-80245888 400-0510-518 | 1258079079@qq.com | China | 46 | 58 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1459 | 58 |
| Huaibei Desung Biotech Co., Ltd. | 0561-2337889 13515618601 | 390478052@qq.com | China | 1967 | 58 |
| Hubei Hengluyuan Technology co.ltd | 027-88188016 18717196322 | 1764683941@qq.com | China | 5944 | 58 |
| Hebei Qiaozhou Pharmaceutical Co., Ltd., | 13722996852 | 13722996852@163.com | China | 12 | 58 |
| Shanghai Yanze Chemical Co., Ltd. | 15345144255 19901447308 | 260924549@qq.com | China | 9989 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
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View Lastest Price from D-Proline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | D-Proline
344-25-2
|
1kg | 98.5%-101% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | D-Proline
344-25-2
|
$1.10-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-21 | D-Proline
344-25-2
|
1kg | 98% | 20t | Hubei Lidu New Material Technology Co., Ltd |
