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ChemicalBook >> CAS DataBase List >>4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Structure
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine structure
CAS No.
150728-13-5
Chemical Name:
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
Synonyms
2,2'-Bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)-;4,6-Dich;Bosentan USP RC D;BOSENTAN INTERMEDIATES;Bosentan interMediate (I);Bosentan Related Compound 1;Bosentan Related CoMpound D;Intermediate of Bosentan (I);Bosentan USP Related Compound D;2,2'-Bipyrimidine,4,6-dichloro-5-(2-methoxyphenox
CBNumber:
CB0511409
Molecular Formula:
C15H10Cl2N4O2
Molecular Weight:
349.17
MDL Number:
MFCD03839838
MOL File:
150728-13-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:50:56
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4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Properties

Melting point 157.0 to 161.0 °C
Boiling point 520.7±60.0 °C(Predicted)
Density 1.418±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka -3.58±0.33(Predicted)
form Solid
color White to Light Brown
Major Application pharmaceutical (small molecule)
InChI InChI=1S/C15H10Cl2N4O2/c1-22-9-5-2-3-6-10(9)23-11-12(16)20-15(21-13(11)17)14-18-7-4-8-19-14/h2-8H,1H3
InChIKey IZGOBGVYADHVKH-UHFFFAOYSA-N
SMILES C1(C2=NC=CC=N2)=NC(Cl)=C(OC2=CC=CC=C2OC)C(Cl)=N1
CAS DataBase Reference 150728-13-5(CAS DataBase Reference)
FDA UNII SLW8S7AP2H
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
WGK Germany  WGK 3
HS Code  2935909550
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D4598 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine >98.0%(GC)(N) 150728-13-5 1g $24 2026-04-30 Buy
TCI Chemical D4598 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine >98.0%(GC)(N) 150728-13-5 5g $75 2026-04-30 Buy
TRC TRC-D434910-1G 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2’-bipyrimidine 150728-13-5 1g $122 2026-06-03 Buy
TRC TRC-D434910-100MG 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2’-bipyrimidine 150728-13-5 100mg $82 2026-06-03 Buy
Usbiological 009202 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2’-bipyrimidine 150728-13-5 5mg $425 2026-06-03 Buy
Product number Packaging Price Buy
D4598 1g $24 Buy
D4598 5g $75 Buy
TRC-D434910-1G 1g $122 Buy
TRC-D434910-100MG 100mg $82 Buy
009202 5mg $425 Buy

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Chemical Properties, Uses, Production

Chemical Properties

Brown solid

Uses

Bosentan USP Related Compound D

Synthesis

5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

150728-12-4

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

150728-13-5

General procedure for the synthesis of 4,6-dichloro-5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]-4,6(1H,5H)-dione from 5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]: Example of implementation: 1. 343.70 g of phosphoryl chloride was added to a reactor followed by 175.0 g of 5-(2-methoxyphenoxy)-[2,2'-dipyrimidin]-4,6(1H,5H)-dione (Compound 1). 2. The reaction mixture was heated to reflux temperature and stirred under reflux conditions for 4.0 hours. The reaction process was monitored by HPLC. 3. Upon completion of the reaction, the reaction mixture was slowly cooled to 40-50 °C. The reaction mixture was then cooled at 5-10 °C. The reaction mixture was then cooled at 5-10 °C. 4. The reaction mixture was quenched by slowly pouring into 2.625 liters of water at 5-10 °C. 5. the reaction mixture was continued to be stirred at 5-10 °C for 2.0 hours. 6. the reaction mixture was filtered and the wet filter cake was washed three times with 175.0 mL of water. 7. The wet filter cake was collected to give 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-dipyrimidine (Compound 2) with a wet weight of 255 g. The reaction was carried out at 55° C. The wet filter cake was washed three times with 175.0 mL of water. 8. The wet filter cake was dried under vacuum at 55-60°C for 8.0 hours. 9. After drying, 182 g of Compound 2 was obtained in 93% yield and >98% HPLC purity.

References

[1] Patent: US2012/136015, 2012, A1. Location in patent: Page/Page column 7
[2] Patent: CN104193687, 2017, B. Location in patent: Paragraph 0133; 0134
[3] Patent: US2008/242687, 2008, A1. Location in patent: Page/Page column 32; 34
[4] Chimia, 1996, vol. 50, # 11, p. 538 - 543
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 17, p. 2223 - 2228

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-5-(2-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine 5-(2-Methoxyphenoxy)-[2,2'-bipyrimidine]-4,6(1H,5H)-dione

Preparation Products

4-Chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-2,2''-bipyrimidine

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Suppliers

Global Suppliers ( 288)
Supplier Tel Email Country ProdList Advantage
Suzhou ChemWe Chemical Co., Ltd. 512-62706911 13401923197 sales@chemwe.com China 94 56
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 029-029-029-81148696 18161915376 1027@dideu.com China 9989 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Yangzhou Siyu Chemical Co.,Ltd. 0514-87325867 sales@siyuchem.com China 370 55
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Suzhou ChemWe Chemical Co., Ltd. 56
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Yangzhou Siyu Chemical Co.,Ltd. 55
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chembest Research Laboratories Limited 61
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine pictures 2026-09-02 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
150728-13-5
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine pictures 2026-06-30 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
150728-13-5
 1kg 98% Shaanxi Dideu New Materials Co. Ltd
4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine pictures 2026-02-02 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
150728-13-5
 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd

150728-13-5 (4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine) Related Search:

3-Methoxyphenethylamine 4-Methoxybenzyl cyanide 4-Methoxybenzyl alcohol Dichloroacetic acid p-Anisaldehyde
(Trifluoromethoxy)benzene 4-Methoxybenzoyl chloride Anisole 3-Methoxyacetophenone BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)-
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- 4-tert-Butylbenzenesulfonamide Bosentan Related Compound 4 4-Methoxybenzoic acid
Bosentan Impurity 15 HCl Bosentan Related Compound 5 Bosentan

1of4

4,6-Dich 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 99% Bosentan Related Compound D (4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine) Bosentan Related Compound D (15 mg) (4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine) Bosentan Related CoMpound D Bosentan Related Compound 1 Bosentan USP Related Compound D: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (bosentan intermediate) Bosentan interMediate (I) 4,6-dichloro-5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)pyriMidine Bosentan USP RC D 2-(4,6-dichloro-5-(2-methoxyphenoxy) pyrimidin-2-yl)pyrimidine 2,2'-Bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)- (bosentan intermediate) 4,6-Dichloro-5-(O-Methoxyphenoxy)-2-(2-Pyrimidinyl)Pyrimidine BOSENTAN INTERMEDIATES 2,2'-Bipyrimidine,4,6-dichloro-5-(2-methoxyphenox 4,6-Dichloro-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl 2-(5-(2-methoxyphenoxy)-4,6-dichloropyrimidin-2-yl)pyrimidine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Bosentan USP Related Compound D 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine > 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine,95% (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine)Q: What is (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What is the CAS Number of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What is the storage condition of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Q: What are the applications of (4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2-Bipyrimidine) Bosentan Related Compound D (4,6-dichloro-5-(2-methoxyphenoxy)-2,2''-bipyrimidine) (1076159) 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine Manufacturer/High quality/Best price/In stock 4,6-Dichloro-5- (2-methoxyphenyloxy) -2,2 '- Dipyrimidine 4,6-dichloro-5-(methoxyphenoxy)-2,2'-bipyrimidine Bosentan Impurity 11(Bosentan USP Related Compound D) Intermediate of Bosentan (I) 2,2'-Bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)- 150728-13-5 C15H10Cl2N4O2 Aromatics Bases & Related Reagents Heterocycles Nucleotides API intermediates pyrimidine