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4-tert-Butylbenzenesulfonamide

4-tert-Butylbenzenesulfonamide Structure
4-tert-Butylbenzenesulfonamide structure
CAS No.
6292-59-7
Chemical Name:
4-tert-Butylbenzenesulfonamide
Synonyms
Bosentan Related CoMpound E;BUTTPARK 44\03-78;Bosentan USP RC E;p-Tosylbenzylamine;Bosentan EP Impurity-E;Bosentan USP Impurity E;t-Butyl bezene sulfonamide;4-t-Butylbenzenesulfonamide;Bosentan Related Compound 2;4-t-Butylbenzenesulphonamide
CBNumber:
CB4406783
Molecular Formula:
C10H15NO2S
Molecular Weight:
213.3
MDL Number:
MFCD00068599
MOL File:
6292-59-7.mol
Last updated:2026-06-12 08:45:15
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4-tert-Butylbenzenesulfonamide Properties

Melting point 136-138°C
Boiling point 337.2±35.0 °C(Predicted)
Density 1.152±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Sparingly)
form Solid
pka 10.22±0.10(Predicted)
color White to Off-White
Major Application pharmaceutical (small molecule)
InChI 1S/C10H15NO2S/c1-10(2,3)8-4-6-9(7-5-8)14(11,12)13/h4-7H,1-3H3,(H2,11,12,13)
InChIKey KYDZEZNYRFJCSA-UHFFFAOYSA-N
SMILES [S](=O)(=O)(N)c1ccc(cc1)C(C)(C)C
CAS DataBase Reference 6292-59-7(CAS DataBase Reference)
FDA UNII 3HBX5G8GUV
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  20/21/22
Safety Statements  22-36/37/39
Hazard Note  Irritant
HS Code  29350090
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

4-tert-Butylbenzenesulfonamide price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1076160 Bosentan Related Compound E 6292-59-7 15mg $1390 2026-04-30 Buy
TCI Chemical B3837 4-tert-Butylbenzenesulfonamide >98.0%(HPLC)(N) 6292-59-7 5g $108 2026-04-30 Buy
TRC TRC-B690735-10G 4-tert-Butylbenzenesulfonamide 6292-59-7 10g $149 2026-06-03 Buy
TRC TRC-B690735-100G 4-tert-Butylbenzenesulfonamide 6292-59-7 100g $1170 2026-06-03 Buy
Biosynth FB140626 4-(tert-Butyl)benzenesulfonamide 6292-59-7 50g $150 2026-06-04 Buy
Product number Packaging Price Buy
1076160 15mg $1390 Buy
B3837 5g $108 Buy
TRC-B690735-10G 10g $149 Buy
TRC-B690735-100G 100g $1170 Buy
FB140626 50g $150 Buy

4-tert-Butylbenzenesulfonamide Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

4-tert-Butylbenzenesulfonamide is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan (B675900).

Synthesis

4-tert-Butylbenzenesulfonyl chloride

15084-51-2

4-tert-Butylbenzenesulfonamide

6292-59-7

A solution of 4-(tert-butyl)benzenesulfonyl chloride (2.30 g, 10.0 mmol) in dichloromethane (100 mL) was added to a 500 mL round bottom flask at 0 °C, followed by the slow addition of concentrated ammonia (50 mL, 100 mmol, 10 equiv). The reaction mixture was gradually warmed to room temperature and stirred continuously for 20 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting slurry was filtered through a Brinell funnel to afford 1.60 g (75% yield) of 4-(tert-butyl)benzenesulfonamide (Compound A) as a white solid.

References

[1] Chemische Berichte, 1993, vol. 126, # 7, p. 1713 - 1722
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 21, p. 3355 - 3368
[3] Patent: US2004/39033, 2004, A1. Location in patent: Page/Page column 16; 64
[4] European Journal of Medicinal Chemistry, 2004, vol. 39, # 10, p. 835 - 847
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 16, p. 4397 - 4406

4-tert-Butylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

4-tert-Butylbenzenesulfonyl chloride Dichloromethane Water Ammonia

Preparation Products

Bosentan Impurity 1

4-tert-Butylbenzenesulfonamide Suppliers

Global( 354)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
EnciPharmatech Co., Ltd 025-52714267-66 13813902930 stephen_shengll@hotmail.com China 231 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
EnciPharmatech Co., Ltd 64

View Lastest Price from 4-tert-Butylbenzenesulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-tert-Butylbenzenesulfonamide pictures 2026-09-02 4-tert-Butylbenzenesulfonamide
6292-59-7
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-tert-Butylbenzenesulfonamide pictures 2026-06-30 4-tert-Butylbenzenesulfonamide
6292-59-7
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
4-tert-Butylbenzenesulfonamide pictures 2026-06-30 4-tert-Butylbenzenesulfonamide
6292-59-7
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

4-tert-Butylbenzenesulfonamide Spectrum

4-tert-Butylbenzenesulfonamide(6292-59-7)1HNMR4-tert-Butylbenzenesulfonamide(6292-59-7)FT-IR

6292-59-7(4-tert-Butylbenzenesulfonamide)Related Search:

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide N-n-Butyl benzene sulfonamide 4-tert-Butylbenzoyl chloride Methyl 4-tert-butylbenzoate tert-Butyl methyl ether
Benzenesulfonamide 3-Aminobenzenesulfonamide 4-tert-Butylphenol 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)-
BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Bosentan Related Compound 4 tert-Butanol Sulfanilamide Bosentan Related Compound 5
Bosentan Impurity 15 HCl 2-Bromo-N-tert-butylbenzenesulfonamide Recombinant Human Telomerase

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BUTTPARK 44\03-78 4-TERT-BUTYLBENZENESULFONAMIDE 4-TERT-BUTYLBENZENESULPHONAMIDE 4-(TERT-BUTYL)BENZENE-1-SULFONAMIDE P-TERT-BUTYL-BENZENESULFONAMIDE TertiaryButylBenzeneSulphonamide 4-(1,1-DIMETHYLETHYL)BENZENESULFONAMIDE 4-TERT-BUTYLBENZENESULFONAMIDE (SEE 5062) 4-t-Butylbenzenesulphonamide Bosentan USP RC E 4-t-Butylbenzenesulfonamide Bosentan Related Compound 2 Bosentan Related Compound E (15 mg) (4-(tert-butyl)benzenesulfonamide) Tert-butyl benzene sulfonamide t-Butyl bezene sulfonamide Bosentan USP Related Compound E: 4-(tert-Butyl)benzenesulfonamide 4-Tertiarybutylbenzene sulphonamine 4-tert-Butylbenzenesulfomide Bosentan USP Related Compound E Tert. Butyl Benzene Sulphonamide 4-tert-Butylbenzenesulfonamide > Benzenesulfonamide, 4-(1,1-dimethylethyl)- 4-tert-Butylbenzenesulfonamide ISO 9001：2015 REACH 4-(tert-Butyl)benzene-1-sulfonamideQ: What is 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the CAS Number of 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the storage condition of 4-(tert-Butyl)benzene-1-sulfonamide Q: What are the applications of 4-(tert-Butyl)benzene-1-sulfonamide Bosentan Related Compound E (4-(tert-butyl)benzenesulfonamide) (1076160) Bosentan Impurity 12(Bosentan USP Related Compound E) 4-Tertiarybutylbenzene sulphonamide Bosentan USP Impurity E 4-TERT-BUTYLBENZENESULFONAMIDE–98% Bosentan EP Impurity-E p-Tosylbenzylamine Bosentan Related CoMpound E 6292-59-7 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals