ChemicalBook >> CAS DataBase List >>4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide structure

CAS No.: 150727-06-3

Chemical Name:: 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

Synonyms: Bosentan USP RC A;BenzenesulfonaMide(II);Bosentan EP Impurity-A;Bosentan Intermediate 2;bosentan intermediate(II);Bosentan Related CoMpound A;Bosentan Related Compound 3;Bosentan USP Related CoMpound A;4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2;Bosentan Impurity 10(Bosentan USP Related Compound A)

CBNumber:: CB5500707

Molecular Formula:: C25H24ClN5O4S

Molecular Weight:: 526.01

MDL Number:: MFCD09751194

MOL File:: 150727-06-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:22:20

Product description	Number	Pack Size	Price
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide	093075	250.00mg	$213
4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide	093075	1.00g	$471
N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	C66174	1g	$68
N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	C66174	5g	$76
N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	C66174	10g	$80
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4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Properties

Melting point	212-214°C
Boiling point	676.7±65.0 °C(Predicted)
Density	1.348±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	3.67±0.10(Predicted)
form	Solid
color	White to Pale Yellow
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C25H24ClN5O4S/c1-25(2,3)16-10-12-17(13-11-16)36(32,33)31-22-20(35-19-9-6-5-8-18(19)34-4)21(26)29-24(30-22)23-27-14-7-15-28-23/h5-15H,1-4H3,(H,29,30,31)
InChIKey	XKISWHVJIZSPSC-UHFFFAOYSA-N
SMILES	C1(S(NC2C(OC3=CC=CC=C3OC)=C(Cl)N=C(C3=NC=CC=N3)N=2)(=O)=O)=CC=C(C(C)(C)C)C=C1
FDA UNII	6ZB6RG7BMX
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
HS Code	2935909550
Storage Class	11 - Combustible Solids

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	093075	4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide	150727-06-3	250.00mg	$213	2026-05-18	Buy
Matrix Scientific	093075	4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide	150727-06-3	1.00g	$471	2026-05-18	Buy
Synthonix	C66174	N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	150727-06-3	1g	$68	2026-05-06	Buy
Synthonix	C66174	N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	150727-06-3	5g	$76	2026-05-06	Buy
Synthonix	C66174	N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide >98%	150727-06-3	10g	$80	2026-05-06	Buy

Product number	Packaging	Price	Buy
093075	250.00mg	$213	Buy
093075	1.00g	$471	Buy
C66174	1g	$68	Buy
C66174	5g	$76	Buy
C66174	10g	$80	Buy

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Chemical Properties,Uses,Production

Chemical Properties

Light Pale Yellow Sold

Uses

An intermediate of Bosentan, which is a mixed endothelin receptor antagonist. Bosentan USP Related Compound A.

Synthesis

6292-59-7

4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

150728-13-5

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide

150727-06-3

In a flask equipped with a mechanical stirrer, thermometer, reflux condenser, dropping funnel and heating jacket, a solution of 4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine (105 g) and 4-(tert-butyl)benzenesulfonamide (64.1 g, 0.30 mol) in DMSO (525 mL) was added. To this suspension was added potassium carbonate (83 g, 0.60 mol). The reaction mixture was heated to 100-105 °C under stirring and maintained for 3-4 hours. The reaction progress was monitored by HPLC. After completion of the reaction, the solution was cooled to 20-25 °C. Water (875 mL) was added slowly dropwise over 10-15 minutes and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed with water (2 x 350 mL) and subsequently transferred to a mortar. Water (800 mL) and concentrated hydrochloric acid (50 mL) were added and stirred for 30 minutes. The precipitated solid was collected by filtration again and washed with water (2 × 200 mL) and acetone (2 × 175 mL) sequentially. The solid was dried under reduced pressure at 40±2 °C for 16-24 h to afford the milky white solid product N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-dipyrimidin]-4-yl]-4-tert-butylbenzenesulfonamide in a yield of 157.8-158.7 g (100% yield).

References

[1] Organic Process Research and Development, 2011, vol. 15, # 6, p. 1382 - 1387
[2] Patent: WO2014/104904, 2014, A1. Location in patent: Page/Page column 13; 14
[3] Organic Process Research and Development, 2013, vol. 17, # 8, p. 1021 - 1026
[4] Patent: WO2012/73135, 2012, A1. Location in patent: Page/Page column 10
[5] Patent: WO2013/57545, 2013, A1. Location in patent: Paragraph 15

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Preparation Products And Raw materials

Raw materials

4-tert-Butylbenzenesulfonamide 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 6-chloro-5-(2-Methoxyphenoxy)-2,2'-bipyriMidin-4-ol Potassium carbonate Dimethyl sulfoxide

Preparation Products

Bosentan Bosentan Impurity 1

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Suppliers

Global( 161)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Moxin Chemicals	+86-17320513646 +8617320513646	anna@molcoo.com	China	10000	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29793	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	029-81140587 +8618717328141	sales@yutbon.com	China	454	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15076	58

Supplier	Advantage
Moxin Chemicals	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
Xi'an Yutbon Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-16	Bosentan Impurity 3 150727-06-3	US $0.00-0.00 / mg	10mg	95	100000	Moxin Chemicals
	2020-01-03	4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide 150727-06-3	US $1.00 / KG	1KG	99%	1kg-1000kg	Career Henan Chemical Co

Bosentan Impurity 3
150727-06-3
US $0.00-0.00 / mg
95
Moxin Chemicals

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
150727-06-3
US $1.00 / KG
99%
Career Henan Chemical Co

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide Spectrum

4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide(150727-06-3)¹HNMR

150727-06-3(4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide)Related Search:

tert-Butyl peroxyacetate 2-Butoxyethanol p-Anisidine Cyhalofop-butyl 4-Methoxybenzyl alcohol

4-Methoxybenzyl cyanide Diethylene glycol monobutyl ether tert-Butyl acetate 4-Methoxyphenol Anisole

(Trifluoromethoxy)benzene Guaiacol Butyl acetate Buprofezin p-Anisaldehyde

Butyl acrylate tert-Butanol 4-tert-Butylbenzenesulfonamide

1of4

N-[6-CHLORO-5-(2-METHOXYPHENOXY)-(2,2-BIPYRIMIDINE)4-4-YL]-(1,1-DIMETHYLETHYL)-BENZENESULFONAMIDE 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide n-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-B Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)- (bosentan intermediate) Benzenesulfonamide, N-[6-Chloro-5-(2-Methoxyphenoxy)[2,2'-Bi-Pyrimidin]-4-Yl]-4-(1,1-Dimethylethyl)-(9ci) 4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2 Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)- N-[6-Chloro-5-(2-methoxphenoxy)(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-(9CI)-benzenesulfonamide 4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide 4-tert-Butyl-N-[6-chloro-5-(2-methoxy-phenoxy) -[2,2']bipyrimidinyl-4-yl]-benzenesulfonamide BenzenesulfonaMide(II) N-[6-CHLORO-5-(2-METHOXYPHENOXY) [2,2-BIPRIMIDIN]-4-(1,1-DIMETHYLETHYL) BENZENESULFONAMIDE Bosentan USP Related CoMpound A Bosentan Related CoMpound A Bosentan Related Compound 3 Bosentan Related Compound A (15 mg) (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl] benzenesulfonamide) Bosentan USP RC A bosentan intermediate(II) Bosentan USP Related Compound A: 4-(tert-Butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl]benzenesulfonamide N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)- n-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimeth N-{6-chloro-5-(2-methoxy phenoxy)[2,2'-bipyrimidin]-4-yl}-4-(1,1-dimethylethyl)benzensulfonamide 4-TERT-BUTYL-N-(6-CHLORO-5- (2-METHOXYPHENOXY)-2,2'- BIPYRIMIDIN-4-YL)BENZENE Bosentan Intermediate 2 Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bi... Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)Q: What is Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What is the CAS Number of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What is the storage condition of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Q: What are the applications of Benzenesulfonamide, N-[6-chloro-5-(2-methoxyphenoxy)[2,2-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl) Bosentan Related Compound A (4-(tert-butyl)-N-[6-chloro-5-(2-methoxyphenoxy)-(2,2''-bipyrimidin)-4-y (1076126) Bosentan Impurity 10(Bosentan USP Related Compound A) N - [6-chloro-5- (2-methoxyphenyloxy) [2,2 '- pyrimidine] -4-yl] -4-tert butylbenzenesulfonamide N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)-Benzenesulfonamide Bosentan EP Impurity-A N-[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-tert-butylbenzenesulfonamide 4-(1,1-dimethylethyl)-N-[6-chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide. 4-tert-Butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]benzenesulfonamide 150727-06-3 C25H26ClN5O4S C25H24ClN5O4S pyrimidine Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals