4-Chloro-2-methoxy-pyridine
- CAS No.
- 72141-44-7
- Chemical Name:
- 4-Chloro-2-methoxy-pyridine
- Synonyms
- IFLAB-BB F2108-0069;4-chloro-methoxypridine;2-METHOXY-4-CHLORO-PYRIDINE;4-Chloro-2-methoxy-pyridine;Pyridine, 4-chloro-2-methoxy-
- CBNumber:
- CB0679255
- Molecular Formula:
- C6H6ClNO
- Molecular Weight:
- 143.57
- MDL Number:
- MFCD06738656
- MOL File:
- 72141-44-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 26℃ |
|---|---|
| Boiling point | 177℃ |
| Density | 1.210 |
| Flash point | 61℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 3.66±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 72141-44-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| HS Code | 2933399990 |
4-Chloro-2-methoxy-pyridine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 269829 | 4-Chloro-2-methoxy-pyridine Asreported | 72141-44-7 | 250mg | $368 | 2026-06-03 | Buy |
| Usbiological | 269829 | 4-Chloro-2-methoxy-pyridine Asreported | 72141-44-7 | 500mg | $509 | 2026-06-03 | Buy |
| Usbiological | 269829 | 4-Chloro-2-methoxy-pyridine Asreported | 72141-44-7 | 1g | $798 | 2026-06-03 | Buy |
| Usbiological | 269829 | 4-Chloro-2-methoxy-pyridine Asreported | 72141-44-7 | 2g | $1114 | 2026-06-03 | Buy |
| Usbiological | 269829 | 4-Chloro-2-methoxy-pyridine Asreported | 72141-44-7 | 5g | $1576 | 2026-06-03 | Buy |
4-Chloro-2-methoxy-pyridine Chemical Properties,Uses,Production
Uses
4-Chloro-2-methoxypyridine is a reagent in the preparation of cyclopalladated ferrocenylimines as efficient catalysts for the preparation of arylboronate esters.
Synthesis
98197-72-9
72141-44-7
General procedure for the synthesis of 4-chloro-2-methoxypyridine from 4-iodo-2-methoxypyridine: (d) 50.6 mL of isopropylmagnesium chloride (2 mol/L tetrahydrofuran solution) was mixed with 19.8 g (84.3 mmol) of the crude product of 4-iodo-2-methoxypyridine made in step (c) dissolved in 80 mL of tetrahydrofuran under ice bath cooling conditions. The reaction mixture was stirred at 0 °C for 1 hour, followed by continued stirring at room temperature for 1 hour. Then, 16.9 g (127 mmol) of N-chlorosuccinimide was slowly added and stirring was continued for 1 hour at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of 100 mL of water and the tetrahydrofuran was removed by distillation under reduced pressure. The reaction mixture was extracted with ether and the organic layer was dried with sodium sulfate, filtered and the solvent was removed by decompression distillation to give 11.0 g (91% crude yield) of 4-chloro-2-methoxypyridine crude product. 1H-NMR (CDCl3, 400 MHz): δ (ppm) = 3.91 (s, 3H), 6.70 (d, 1H, J = 2.0 Hz), 6.81 (dd, 1H, J = 6.0 Hz, 2.0 Hz), 7.99 (d, 1H, J = 6.0 Hz).
References
[1] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 7
4-Chloro-2-methoxy-pyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 4-Chloro-2-methoxy-pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 4-CHLORO-2-METHOXY-PYRIDINE
72141-44-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-CHLORO-2-METHOXY-PYRIDINE
72141-44-7
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 4-CHLORO-2-METHOXY-PYRIDINE
72141-44-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-CHLORO-2-METHOXY-PYRIDINE
72141-44-7
- $1.00
- 98%
- Career Henan Chemical Co
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