4-Amino-2-methoxypyridine
- CAS No.
- 20265-39-8
- Chemical Name:
- 4-Amino-2-methoxypyridine
- Synonyms
- 2-Methoxypyridin-4-amine;NSC 133109;2-Methoxypyridin-aMine;2-Methoxy-4-myridinamine;2-Methoxy-4-pyridinamine;2-METHOXY-4-AMINOPYRIDINE;4-PyridinaMine,2-Methoxy-;4-Amino-6-methoxypyridine;2-Methoxy-4-pyridineamine;4-AMINO-2-METHOXYPYRIDINE
- CBNumber:
- CB8435107
- Molecular Formula:
- C6H8N2O
- Molecular Weight:
- 124.14
- MDL Number:
- MFCD06738657
- MOL File:
- 20265-39-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 87-88°C |
|---|---|
| Boiling point | 271.7±20.0 °C(Predicted) |
| Density | 1.139±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 7.29±0.30(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 20265-39-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
4-Amino-2-methoxypyridine price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000354 | 2-Methoxy-pyridin-4-ylamine Aldrich | 20265-39-8 | 1g | $482 | 2024-03-01 | Buy |
| TCI Chemical | A2543 | 4-Amino-2-methoxypyridine >98.0%(GC)(T) | 20265-39-8 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | A2543 | 4-Amino-2-methoxypyridine >98.0%(GC)(T) | 20265-39-8 | 5g | $116 | 2026-04-30 | Buy |
| AstaTech | 52127 | 4-AMINO-2-METHOXYPYRIDINE 97% | 20265-39-8 | 5G | $10 | 2026-04-30 | Buy |
| AstaTech | 52127 | 4-AMINO-2-METHOXYPYRIDINE 97% | 20265-39-8 | 25G | $29 | 2026-04-30 | Buy |
4-Amino-2-methoxypyridine Chemical Properties, Uses, Production
Chemical Properties
Off-white solid
Uses
4-Amino-2-methoxypyridine serves as a precursor for synthesizing 4-aminopyridyl-based inhibitors by replacing 4-aminopyridine[2].
Synthesis
14432-12-3
20265-39-8
General procedure for the synthesis of 4-amino-2-methoxypyridine from 2-chloro-4-aminopyridine: 4-amino-2-chloropyridine (15 g, 117 mmol, 1.0 equiv) was dissolved in 100 mL of tetrahydrofuran (THF). To this solution was added a methanolic solution of sodium methanolate (1.0 M, 234 mL, 234 mmol, 2.0 eq.), and the mixture was subsequently transferred to a sealed tube and the reaction was refluxed for 16 hours at 140 °C. Upon completion of the reaction, the reaction mixture was slowly poured into 500 mL of rapidly stirred saturated aqueous sodium bicarbonate solution. The organic and aqueous layers were separated by adding 500 mL of ethyl acetate for extraction. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. Finally, purification by silica gel column chromatography (eluent: 30% hexane solution of ethyl acetate) gave the target product 4-amino-2-methoxypyridine (2.1 g, 14% yield) as a yellow solid.
References
[1] Patent: WO2009/154769, 2009, A1. Location in patent: Page/Page column 53
[2]Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., & Roush, W. R. (2013). Rational Development of 4-Aminopyridyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51 as Anti-Chagas Agents. Journal of Medicinal Chemistry, 56(19), 7651–7668. https://doi.org/10.1021/jm401067s
4-Amino-2-methoxypyridine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 4-Amino-2-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Methoxy-4-pyridinamine
20265-39-8
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 4-Amino-2-methoxypyridine
20265-39-8
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 4-Amino-2-methoxypyridine
20265-39-8
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Methoxy-4-pyridinamine
20265-39-8
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Amino-2-methoxypyridine
20265-39-8
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Amino-2-methoxypyridine
20265-39-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
