2-Methoxy-4-methylpyridine
- CAS No.
- 100848-70-2
- Chemical Name:
- 2-Methoxy-4-methylpyridine
- Synonyms
- CAS:100848-70-2;2-Methoxy-p-picoline;2-METHOXY-4-PICOLINE;2-METHOXY-4-METHYLPYRIDINE;2-METHOXY-4-METHYLPYRIDINEV;Pyridine, 2-methoxy-4-methyl-;2-Methoxy-4-methylpyridine>2-Methoxy-4-methylpyridine 97%;2-Methoxy-4-Methylpyridine,97%;Pyridine, 2-methoxy-4-methyl- (9CI)
- CBNumber:
- CB1442933
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MDL Number:
- MFCD06200799
- MOL File:
- 100848-70-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 136 °C |
|---|---|
| Boiling point | 152-153 °C (lit.) |
| Density | 1.001±0.06 g/cm3(Predicted) |
| refractive index | 1.4990-1.5030 |
| Flash point | 53 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 4.07±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| InChI | 1S/C7H9NO/c1-6-3-4-8-7(5-6)9-2/h3-5H,1-2H3 |
| InChIKey | HGRXBKDKSYDWLD-UHFFFAOYSA-N |
| SMILES | COc1cc(C)ccn1 |
| CAS DataBase Reference | 100848-70-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 16-26-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Methoxy-4-methylpyridine price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 578525 | 2-Methoxy-4-methylpyridine 97% | 100848-70-2 | 5g | $197 | 2023-06-20 | Buy |
| TCI Chemical | M2190 | 2-Methoxy-4-methylpyridine >98.0%(GC) | 100848-70-2 | 1g | $51 | 2026-04-30 | Buy |
| TCI Chemical | M2190 | 2-Methoxy-4-methylpyridine >98.0%(GC) | 100848-70-2 | 5g | $157 | 2026-04-30 | Buy |
| Usbiological | 230492 | 2-Methoxy-4-methylpyridine 99+% (GC) ≥99%(GC) | 100848-70-2 | 1g | $215 | 2026-06-03 | Buy |
| Usbiological | 230492 | 2-Methoxy-4-methylpyridine 99+% (GC) ≥99%(GC) | 100848-70-2 | 5g | $390 | 2026-06-03 | Buy |
2-Methoxy-4-methylpyridine Chemical Properties, Uses, Production
Description
2-Methoxy-4-methylpyridine is an organic intermediate, which can be prepared by nucleophilic substitution of 2-chloro-4-methylpyridine with sodium methoxide.
Uses
2-Methoxy-4-methylpyridine is a heterocyclic organic compound and can be used as an organic intermediate.
Preparation
The mixture of 2-chloro-4-picoline and NaOCH3 in DMSO was extracted with ethyl acetate and reacted to obtain 2-methoxy-4-picoline.
Synthesis
13466-41-6
74-88-4
100848-70-2
To a stirred solution of 2-hydroxy-4-methylpyridine (10 g, 92 mmol) in chloroform (350 mL) was sequentially added silver carbonate (34.2 g, 124 mmol) and iodomethane (130 g, 920 mmol) at room temperature. The reaction mixture was stirred continuously under light-avoidance conditions for 48 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with ether. The filtrate was concentrated at a temperature below 20 °C and the resulting residue was purified by column chromatography using n-pentane/ether (5:1, v/v) as eluent to afford 2-methoxy-4-methylpyridine (8.0 g, 71% yield) as a colorless oil. The structure of the product was characterized by 1H NMR (CDCl3, δ): 8.02 (d, 1H, J=5.4 Hz), 6.69 (d, 1H, J=5.4 Hz), 6.55 (s, 1H), 3.91 (s, 3H), 2.28 (s, 3H); 13C NMR (CDCl3, δ): 164.40, 149.72, 146.31. 118.21, 110.88, 53.17, 20.81; Mass Spectrometry (MS) m/z (relative abundance): 123 (M+, 76%), 122 (100%) confirmed.
References
[1] Tetrahedron Letters, 1997, vol. 38, # 35, p. 6153 - 6156
[2] Patent: WO2005/806, 2005, A2. Location in patent: Page 72
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 6, p. 921 - 924
2-Methoxy-4-methylpyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Heze Bona Medical Technology Co., LTD | 15865805009 | 15865805009@139.com | China | 2995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
View Latest Price from 2-Methoxy-4-methylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Methoxy-4-methylpyridine
100848-70-2
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 2-Methoxy-4-methylpyridine
100848-70-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
