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2-Cyano-N-(4-methylphenyl)ethanethioamide

2-Cyano-N-(4-methylphenyl)ethanethioamide Structure
2-Cyano-N-(4-methylphenyl)ethanethioamide structure
CAS No.
6127-18-0
Chemical Name:
2-Cyano-N-(4-methylphenyl)ethanethioamide
Synonyms
4-BroMo-2-Methyl-1H-indole;TOSLAB 23085;4-BroMo-2-Methylindole;1H-Indole,4-bromo-2-methyl-;2-Cyano-N-(4-methylphenyl)ethanethioamide
CBNumber:
CB0680068
Molecular Formula:
C9H8BrN
Molecular Weight:
210.07
MDL Number:
MFCD18380829
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-09-12 18:48:27
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2-Cyano-N-(4-methylphenyl)ethanethioamide Properties

storage temp. 2-8°C
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C9H8BrN/c1-6-5-7-8(10)3-2-4-9(7)11-6/h2-5,11H,1H3
InChIKey MXRPXKYWAYTGJY-UHFFFAOYSA-N
SMILES N1C2=C(C(Br)=CC=C2)C=C1C
CAS DataBase Reference 6127-18-0

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-Cyano-N-(4-methylphenyl)ethanethioamide price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS37064 4-Bromo-2-methyl-1H-indole 98% 6127-18-0 1g $138 2026-06-04 Buy
Activate Scientific AS37064 4-Bromo-2-methyl-1H-indole 98% 6127-18-0 5g $546 2026-06-04 Buy
Matrix Scientific 307247 4-Bromo-2-methyl-1H-indole 6127-18-0 1.00g $91 2026-05-19 Buy
Matrix Scientific 307247 4-Bromo-2-methyl-1H-indole 6127-18-0 5.00g $378 2026-05-19 Buy
Matrix Scientific 307247 4-Bromo-2-methyl-1H-indole 6127-18-0 25.00g $1318 2026-05-19 Buy
Product number Packaging Price Buy
AS37064 1g $138 Buy
AS37064 5g $546 Buy
307247 1.00g $91 Buy
307247 5.00g $378 Buy
307247 25.00g $1318 Buy

2-Cyano-N-(4-methylphenyl)ethanethioamide Chemical Properties, Uses, Production

Synthesis

1H-Indole, 4-bromo-2-methyl-1-(phenylsulfonyl)-

1232861-11-8

2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE

6127-18-0

The general procedure for the synthesis of 4-bromo-2-methyl-1H-indole using the compound (CAS:1232861-11-8) as starting material was as follows: sodium hydroxide (4.01 g, 0.1 mol) was added to a mixture of methanol (80 mL) and water (40 mL) of intermediate 3 (7.0 g, 20.1 mmol). The reaction mixture was stirred at 50 °C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, petroleum ether/ethyl acetate=5:1 as eluent) to afford the target product 4-bromo-2-methyl-1H-indole 4 (3.0 g, 71% yield). Low resolution mass spectrometry (LRMS) (M+H+) m/z: calculated value 209.98; measured value 210.12.

References

[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 186; 187
[2] Patent: US2010/160647, 2010, A1. Location in patent: Page/Page column 18-19
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9480 - 9497

2-Cyano-N-(4-methylphenyl)ethanethioamide Preparation Products And Raw materials

Raw materials

1H-Indole, 4-bromo-2-methyl-1-(phenylsulfonyl)- 2-(2-bromophenyl)-3-methyl-2H-azirine Sodium hydroxide Water Methanol

Preparation Products

2-Cyano-N-(4-methylphenyl)ethanethioamide Suppliers

Global Suppliers ( 99)
Supplier Tel Email Country ProdList Advantage
Beijing YiboYuntian Technology Co., Ltd. 13811826434 lichen13811826434@126.com China 702 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Dtchem Laboratories,（Gan Su）Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 773 61
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3980 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
SynAsst Chemical. 021-60343070 China 12731 55
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3537 55
Shanghai Huikai Chemical Technology Co., Ltd. 021-61995394 18916691159 chemicalsea@163.com China 1970 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
Beijing YiboYuntian Technology Co., Ltd. 58
Shanghai Hanhong Scientific Co.,Ltd. 64
Dtchem Laboratories,（Gan Su）Co.,Ltd. 61
Wuhan TCASChem Technology Co., Ltd. 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
SynAsst Chemical. 55
Wuhan Kaymke Chemical Co., Ltd., 55
Shanghai Huikai Chemical Technology Co., Ltd. 58
Bide Pharmatech Ltd. 60

View Latest Price from 2-Cyano-N-(4-methylphenyl)ethanethioamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Bromo-2-methyl-1H-indole pictures 2025-04-04 4-Bromo-2-methyl-1H-indole
6127-18-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-Cyano-N-(4-methylphenyl)ethanethioamide Spectrum

2-CYANO-N-(4-METHYLPHENYL)ETHANETHIOAMIDE(6127-18-0)1HNMR

6127-18-0 (2-Cyano-N-(4-methylphenyl)ethanethioamide) Related Search:

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1of2

TOSLAB 23085 1H-Indole,4-bromo-2-methyl- 4-BroMo-2-Methylindole 4-BroMo-2-Methyl-1H-indole 2-Cyano-N-(4-methylphenyl)ethanethioamide 6127-18-0