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Sinomenine hydrochloride

Sinomenine hydrochloride Structure
Sinomenine hydrochloride structure
CAS No.
6080-33-7
Chemical Name:
Sinomenine hydrochloride
Synonyms
Sinomenin HCl;SINOMENINE HCL;Kukoline hydrochloride;Cucoline hydrochloride;Sinomenine Hydrocloride;Tuduranine Hydrochloride;Sinomenine HCl Dihydrate;Sinomenine hydrochloride;Sabianine A hydrochloride;Sinomenine hydrochloride-RM
CBNumber:
CB6245173
Molecular Formula:
C19H23NO4.ClH
Molecular Weight:
365.85
MDL Number:
MFCD01714307
MOL File:
6080-33-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:07
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Sinomenine hydrochloride Properties

Melting point 231.0 to 235.0 °C
storage temp. Inert atmosphere,2-8°C
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
optical activity [α]/D -70 to -90°, c = 1 in H2O
Water Solubility Soluble to 100 mM in water
InChI InChI=1/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/s3
InChIKey YMEVIMJAUHZFMW-FSYSDVFBNA-N
SMILES OC1C(=CC=C2C[C@]3([H])N(CC[C@]4(CC(C(=C[C@@]43[H])OC)=O)C2=1)C)OC.Cl |&1:7,12,17,r|
FDA UNII 2J34HRJ45S

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351
Precautionary statements  P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313
Safety Statements  24/25
WGK Germany  3
RTECS  QD2163000
HS Code  29334900
NFPA 704
0
3 0

Sinomenine hydrochloride price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1002 Sinomenine hydrochloride ≥98% (HPLC) 6080-33-7 50mg $129 2026-04-30 Buy
TCI Chemical S0926 Sinomenine Hydrochloride >98.0%(HPLC)(T) 6080-33-7 1g $117 2023-01-07 Buy
TCI Chemical S0926 Sinomenine Hydrochloride >98.0%(HPLC)(T) 6080-33-7 5g $402 2022-04-27 Buy
Cayman Chemical 16143 Sinomenine (hydrochloride) ≥98% 6080-33-7 50mg $36 2026-04-30 Buy
Cayman Chemical 16143 Sinomenine (hydrochloride) ≥98% 6080-33-7 100mg $49 2026-04-30 Buy
Product number Packaging Price Buy
SML1002 50mg $129 Buy
S0926 1g $117 Buy
S0926 5g $402 Buy
16143 50mg $36 Buy
16143 100mg $49 Buy

Sinomenine hydrochloride Chemical Properties, Uses, Production

Description

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.

Chemical Properties

White Solid

Uses

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.

in vivo

Sinomenine hydrochloride (i.p.) produces antinociception in the hot plate and tail flick tests in male rats at 40 mg/kg, but not at lower doses (10 or 20 mg/kg). At 10 to 40 mg/kg Sinomenine hydrochloride does not produce any observable side effect such as sedation, allergy or motor impairments. Sinomenine hydrochloride at 80 mg/kg i.p. does not produce any observable side effects in mice. I.p or p.o. Sinomenine hydrochloride at 40 or 80 mg/kg dose-dependently reduces mechanical hypersensitivity in nerve injured mice. I.p. Sinomenine hydrochloride at 40 mg/kg, but not lower doses or vehicle, significantly decreases mechanical and cold allodynia for up to 240 min without producing motor deficits or sedation[3]. At doses of 10 to 40 mg/kg, Sinomenine hydrochloride dose-dependently increases the paw withdrawal threshold. In non-chronic constriction injury (CCI) healthy rats, Sinomenine hydrochloride at the dose range of 10 to 40 mg/kg does not change the immobility behavior in the forced swimming test[4].

IC 50

NF-κB; μ Opioid Receptor/MOR

Purification Methods

Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]

References

[1] QUANXING WANG  Xiao K L. Immunosuppressive and anti-inflammatory activities of sinomenine[J]. International immunopharmacology, 2011, 11 3: Pages 373-376. DOI: 10.1016/j.intimp.2010.11.018
[2] MAYEDA H. THE SITE OF HISTAMINE RELEASE BY SINOMENINE*[J]. Japanese journal of pharmacology, 1954, 3 2: Pages 73-81. DOI: 10.1254/jjp.3.73
[3] YUE SUN  Cong zhu D  Yao Yao. A combination of Sinomenine and Methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines[J]. International immunopharmacology, 2014, 18 1: Pages 135-141. DOI: 10.1016/j.intimp.2013.11.014
[4] MIN XU. Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis.[J]. Planta medica, 2008, 74 12: 1423-1429. DOI: 10.1055/s-2008-1081346
[5] KRITIKA KESARWANI  Rajiv G. Bioavailability enhancers of herbal origin: An overview[J]. Asian Pacific journal of tropical biomedicine, 2013, 3 4: Pages 253-266. DOI: 10.1016/s2221-1691(13)60060-x
[6] ZHEN LIU. Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression.[J]. PLoS ONE, 2014: e98560. DOI: 10.1371/journal.pone.0098560

Sinomenine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Sinomenine hydrochloride Suppliers

Global Suppliers ( 280)
Supplier Tel Email Country ProdList Advantage
Nantong Feiyu Biological Technology CO.,LTD 0513-68819626 15152877458 feiyubio@163.com China 4796 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Supplier Advantage
Nantong Feiyu Biological Technology CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
BioBioPha Co., Ltd. 65
ShangHai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from Sinomenine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SINOMENINE HYDROCHLORIDE pictures 2026-09-11 SINOMENINE HYDROCHLORIDE
6080-33-7
 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
SINOMENINE HYDROCHLORIDE pictures 2026-08-25 SINOMENINE HYDROCHLORIDE
6080-33-7
 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Sinomenine Hydrochloride pictures 2026-07-28 Sinomenine Hydrochloride
6080-33-7
 1kg 98%HPLC 1 ton Hovane Phytochemicals Co., Ltd

Sinomenine hydrochloride Spectrum

SINOMENINE HYDROCHLORIDE(6080-33-7)MS

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hydroxy-dimethoxy-methyl-BLAH-azatetracyclo[BLAH]hexadeca-BLAH,BLAH,BLAH,BLAH-tetraenone Sinomenine Hydrocloride Cucoline hydrochloride (9a,13a,14a)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride SINOMENINE HCL (9α,13α,14α)- 7,8-Didehydro-4- hydroxy-3,7-diMet 7,8-Didehydro-4-hydroxy-3,7-diMethoxy-17-Methyl- 9α,13α,14α-Morphinan-6-one Hydrochloride Tuduranine Hydrochloride Sinomenine hydrochloride (Cucoline hydrochloride) Sinomenine Hydrochloride > Kukoline hydrochloride Sabianine A hydrochloride 9α,13α,14α-Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride TIANFU-CHEM CAS:6080-33-7 SINOMENINE HYDROCHLORIDE Sinomenine hydrochloride (Cucoline) Sinomenine HCl Dihydrate Sinomenine hydrochloride (6CI, 7CI) Sinomenin HCl 98% Sinomenine Hydrochloride Powder Sinomenine Hydrochloride, ≥ 98.0% Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9α,13α,14α)- (4bR,8aS,9S)-4-Hydroxy-3,7-dimethoxy-11-methyl-9,10-dihydro-5H-9,4b-(epiminoethano)phenanthren-6(8aH)-one hydrochloride Sinomenine hydrochloride-RM Sinomenine hydrochloride, Morphinan analog Sinomenine hydrochloride, 10 mM in DMSO Sinomenine hydrochloride 99% (4b-R,8a-S,9S)-4-hydroxy-3,7-dimethoxy-1-methyl-9,10-dihydro-5H-9,4b-(aminoethanol)phenanthrene-6(8a-H)-onehydrochloride Sinomenine hydrochloride (Standard) Sinomenine hydrochloride 6080-33-7 C19H23NO4HCl Alkaloids Inhibitors pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract chemical reagent Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals APIs