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4-Chloro-6-methoxypyrimidine

4-Chloro-6-methoxypyrimidine Structure
4-Chloro-6-methoxypyrimidine structure
CAS No.
26452-81-3
Chemical Name:
4-Chloro-6-methoxypyrimidine
Synonyms
4-CHLORO-6-METHOXYPYRIMIDINE;4-Chloro-6-methoxy-1,3-diazine;Pyrimidine, 4-chloro-6-methoxy-;4-Chloro-6-methoxypyrimidine >4-Chloro-6-methoxypyrimidine 98%;4-Chloro-6-methoxypyrimidine 98+%;6-CHLORO-4-PYRIMIDINYL METHYL ETHER;4-Chloro-6-MethoxypyriMidine（in stock）;4-Chloro-6-MethoxypyriMidine, 98.0%(GC);4-chloro-6-methoxypyrimidine(SALTDATA: FREE)
CBNumber:
CB0729547
Molecular Formula:
C5H5ClN2O
Molecular Weight:
144.56
MDL Number:
MFCD06200211
MOL File:
26452-81-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-30 10:48:35
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4-Chloro-6-methoxypyrimidine Properties

Melting point 34.5-35.0 °C
Boiling point 80°C/18mmHg(lit.)
Density 1.292±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to lump to clear liquid
pka -1.59±0.17(Predicted)
color White or Colorless to Light yellow
InChI InChI=1S/C5H5ClN2O/c1-9-5-2-4(6)7-3-8-5/h2-3H,1H3
InChIKey KLJGSQVYUGQOAW-UHFFFAOYSA-N
SMILES C1=NC(OC)=CC(Cl)=N1
CAS DataBase Reference 26452-81-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-39
HS Code  29335990
NFPA 704
0
2 0

4-Chloro-6-methoxypyrimidine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2369 4-Chloro-6-methoxypyrimidine >98.0%(GC) 26452-81-3 1g $49 2026-04-30 Buy
TCI Chemical C2369 4-Chloro-6-methoxypyrimidine >98.0%(GC) 26452-81-3 5g $195 2026-04-30 Buy
Activate Scientific AS50161 4-Chloro-6-methoxypyrimidine 98% 26452-81-3 5g $26 2026-06-04 Buy
Activate Scientific AS50161 4-Chloro-6-methoxypyrimidine 98% 26452-81-3 25g $58 2026-06-04 Buy
Activate Scientific AS50161 4-Chloro-6-methoxypyrimidine 98% 26452-81-3 100g $103 2026-06-04 Buy
Product number Packaging Price Buy
C2369 1g $49 Buy
C2369 5g $195 Buy
AS50161 5g $26 Buy
AS50161 25g $58 Buy
AS50161 100g $103 Buy

4-Chloro-6-methoxypyrimidine Chemical Properties, Uses, Production

Uses

4-Chloro-6-methoxypyrimidine could be the starting material for preparing 4-chloro-6-hydroxypyrimidine.

Synthesis

Methanol

67-56-1

4,6-Dichloropyrimidine

1193-21-1

4-Chloro-6-methoxypyrimidine

26452-81-3

A) Methanol (5.4 mL) was slowly added dropwise to a suspension of tetrahydrofuran (THF, 200 mL) containing 60% sodium hydride (8.05 g) under nitrogen protection, keeping the reaction temperature at 0 °C. Subsequently, a solution of 4,6-dichloropyrimidine (20.0 g) in THF (45 mL) was added to the reaction system at 0 °C, and the reaction continued to be stirred at 0 °C for 1 hour. Upon completion of the reaction, 1N hydrochloric acid was slowly added to the reaction mixture at 0 °C for neutralization, followed by extraction of the reaction product with ethyl acetate. The organic phase was washed sequentially with water and saturated brine and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was recrystallized by hexane to afford the target product 4-chloro-6-methoxypyrimidine (10.2 g) as light yellow crystals. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 3.96 (3H, s), 7.19 (1H, s), 8.69 (1H, s).

References

[1] Tetrahedron Letters, 2005, vol. 46, # 23, p. 3977 - 3979
[2] European Journal of Medicinal Chemistry, 2005, vol. 40, # 9, p. 862 - 874
[3] Patent: US2013/143870, 2013, A1. Location in patent: Paragraph 0267; 0268; 0269
[4] Patent: US2013/137688, 2013, A1. Location in patent: Paragraph 0221; 0222; 0223; 0224
[5] Patent: US2013/158038, 2013, A1. Location in patent: Paragraph 0134; 0135

4-Chloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Methanol 4,6-Dichloropyrimidine Sodium Methoxide Mineral oil Tetrahydrofuran
Sodium hydride

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Preparation Products

4-Chloro-6-methoxypyrimidine Suppliers

Global Suppliers ( 227)
Supplier Tel Email Country ProdList Advantage
Tianjin Ji Ping Jia Chemical Co., Ltd. 18622448868 jpjchem@163.com China 489 62
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Tianjin Ji Ping Jia Chemical Co., Ltd. 62
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 4-Chloro-6-methoxypyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-6-methoxypyrimidine pictures 2026-07-30 4-Chloro-6-methoxypyrimidine
26452-81-3
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
4-Chloro-6-methoxypyrimidine pictures 2025-06-25 4-Chloro-6-methoxypyrimidine
26452-81-3
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
4-Chloro-6-methoxypyrimidine pictures 2021-08-12 4-Chloro-6-methoxypyrimidine
26452-81-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4-Chloro-6-methoxypyrimidine Spectrum

4-Chloro-6-methoxypyrimidine(26452-81-3)1HNMR

26452-81-3 (4-Chloro-6-methoxypyrimidine) Related Search:

m-Anisyl alcohol Anisole (Trifluoromethoxy)benzene p-Anisidine Epichlorohydrin
4-Methoxybenzylchloride Methoxyacetic acid 4-Chloro-6-methoxyquinoline Difluorochloromethane Moxonidine
4-chloro-6-methoxy-2-methylpyrimidin-5-amine 2,4-Dichloro-6-methoxypyrimidine 2-Amino-4-chloro-6-methoxypyrimidine Chlorimuron-ethyl 2-Amino-4-chloro-6-ethoxypyrimidine
6-Chloro-2,4-dimethoxypyrimidine 4-Benzyloxy-6-chloropyrimidine Chloroacetic acid

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6-CHLORO-4-PYRIMIDINYL METHYL ETHER 4-CHLORO-6-METHOXYPYRIMIDINE Pyrimidine, 4-chloro-6-methoxy- (6CI,8CI,9CI) 4-Chloro-6-methoxy-1,3-diazine 4-chloro-6-methoxypyrimidine(SALTDATA: FREE) 4-Chloro-6-methoxypyrimidine 98+% Pyrimidine, 4-chloro-6-methoxy- 4-Chloro-6-MethoxypyriMidine, 98.0%(GC) 4-Chloro-6-MethoxypyriMidine（in stock） 4-Chloro-6-methoxypyrimidine 98% 4-Chloro-6-methoxypyrimidine > 4-Chloro-6-methoxypyrimidine ISO 9001：2015 REACH 26452-81-3 C5H5ClN2O Heterocycle-Pyrimidine series alkyl chloride PYRIMIDINE APIs & Intermediate API intermediates