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2,4-Dichloro-6-methoxypyrimidine

2,4-Dichloro-6-methoxypyrimidine structure

CAS No.: 43212-41-5

Chemical Name:: 2,4-Dichloro-6-methoxypyrimidine

Synonyms: 2,4-Dichloro-6-methoxypyrimidine;2,6-Dichloro-4-methoxypyrimidine;2,4-Dichloro-6-methoxy-1,3-diazine;Pyrimidine, 2,4-dichloro-6-methoxy-;2,4-Dichloro-6-methoxypyrimidine,>97%;2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH

CBNumber:: CB22203876

Molecular Formula:: C5H4Cl2N2O

Molecular Weight:: 179

MDL Number:: MFCD00955635

MOL File:: 43212-41-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
2,4-Dichloro-6-methoxypyrimidine	D435310	100mg	$55
2,4-Dichloro-6-methoxypyrimidine	FD71632	100mg	$60
2,4-Dichloro-6-methoxypyrimidine	W6269	100mg	$77
2,4-Dichloro-6-methoxypyrimidine	OR301155	250mg	$87
2,4-Dichloro-6-methoxypyrimidine 95%	4H07-5-02	250mg	$96
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2,4-Dichloro-6-methoxypyrimidine Properties

Boiling point	263.2±20.0 °C(Predicted)
Density	1.446±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-4.54±0.30(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C5H4Cl2N2O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3
InChIKey	ZSNZDRHTTWBNGI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC(OC)=CC(Cl)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H317-H351b
Precautionary statements	P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
Hazard Codes	Xn
Risk Statements	22-36
Safety Statements	26
HS Code	2933599590

2,4-Dichloro-6-methoxypyrimidine price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D435310	2,4-Dichloro-6-methoxypyrimidine	43212-41-5	100mg	$55	2021-12-16	Buy
Biosynth Carbosynth	FD71632	2,4-Dichloro-6-methoxypyrimidine	43212-41-5	100mg	$60	2021-12-16	Buy
AK Scientific	W6269	2,4-Dichloro-6-methoxypyrimidine	43212-41-5	100mg	$77	2021-12-16	Buy
Apolloscientific	OR301155	2,4-Dichloro-6-methoxypyrimidine	43212-41-5	250mg	$87	2021-12-16	Buy
SynQuest Laboratories	4H07-5-02	2,4-Dichloro-6-methoxypyrimidine 95%	43212-41-5	250mg	$96	2021-12-16	Buy

Product number	Packaging	Price	Buy
D435310	100mg	$55	Buy
FD71632	100mg	$60	Buy
W6269	100mg	$77	Buy
OR301155	250mg	$87	Buy
4H07-5-02	250mg	$96	Buy

2,4-Dichloro-6-methoxypyrimidine Chemical Properties,Uses,Production

Uses

2,4-Dichloro-6-methoxypyrimidine is an intermediate used to prepare piperazinyl pyrimidine derivatives as γ-secretase modulators. It is also used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino)pyrimidines and -pyrazines as selective JAK2 inhibitors.

Synthesis

29458-38-6

43212-41-5

General procedure for the synthesis of 2,4-dichloro-6-methoxypyrimidine from 6-methoxypyrimidine-2,4(1H,3H)-dione: 6-methoxypyrimidine-2,4(1H,3H)-dione (15 g, 0.106 mol) was mixed with phosphorus triclosan (400 ml) and heated and refluxed for 4 h. After completion of the reaction the excess of phosphorus triclosan was removed by distillation under reduced pressure. The residue was quenched with an ice-water mixture and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford 2,4-dichloro-6-methoxypyrimidine as an oil (5.5 g, 30% yield). Nuclear Magnetic Resonance Hydrogen Spectroscopy (NMR) data: δ 3.96 (3H, single peak), 6.63 (1H, single peak); Mass Spectrum (m/z): 179 [MH]+.

References

[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 96
[2] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1416 - 1421
[3] Patent: WO2006/109026, 2006, A1. Location in patent: Page/Page column 97
[4] Patent: WO2008/117051, 2008, A1. Location in patent: Page/Page column 29
[5] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00162

2,4-Dichloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

6-METHOXYURACIL 2,4,6-Trichloropyrimidine Sodium Methoxide

Preparation Products

2,4-Dichloro-6-methoxypyrimidine Suppliers

Global( 113)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9545	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Suzhou Victorypharm Co.,Ltd.	+86-13916956214	sales@victory-pharm.com	China	1299	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1249	58

Supplier	Advantage
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Hefei Hirisun Pharmatech Co., Ltd	58
Suzhou Victorypharm Co.,Ltd.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 2,4-Dichloro-6-methoxypyrimidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-06-25	2,4-Dichloro-6-methoxypyrimidine 43212-41-5	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
	2024-10-22	2,4-Dichloro-6-methoxypyrimidine 43212-41-5	US $0.37 / KG	1KG	99%	10kg/100kg	Career Henan Chemica Co

2,4-Dichloro-6-methoxypyrimidine
43212-41-5
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2,4-Dichloro-6-methoxypyrimidine
43212-41-5
US $0.37 / KG
99%
Career Henan Chemica Co

2,4-Dichloro-6-methoxypyrimidine Spectrum

2,4-Dichloro-6-methoxypyrimidine(43212-41-5)¹HNMR

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2,4-Dichloro-6-methoxypyrimidine Pyrimidine, 2,4-dichloro-6-methoxy- 2,4-Dichloro-6-methoxy-1,3-diazine 2,6-Dichloro-4-methoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine,>97% 2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH 43212-41-5 Heterocycle-Pyrimidine series