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ChemicalBook >> CAS DataBase List >>2,4-Dichloro-6-methoxypyrimidine

2,4-Dichloro-6-methoxypyrimidine

2,4-Dichloro-6-methoxypyrimidine Structure
2,4-Dichloro-6-methoxypyrimidine structure
CAS No.
43212-41-5
Chemical Name:
2,4-Dichloro-6-methoxypyrimidine
Synonyms
2,4-Dichloro-6-methoxypyrimidine;2,6-Dichloro-4-methoxypyrimidine;2,4-Dichloro-6-methoxy-1,3-diazine;Pyrimidine, 2,4-dichloro-6-methoxy-;2,4-Dichloro-6-methoxypyrimidine,>97%;2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH
CBNumber:
CB22203876
Molecular Formula:
C5H4Cl2N2O
Molecular Weight:
179
MDL Number:
MFCD00955635
MOL File:
43212-41-5.mol
MSDS File:
SDS
Last updated:2026-05-28 00:02:43
Request For Quotation

2,4-Dichloro-6-methoxypyrimidine Properties

Boiling point 263.2±20.0 °C(Predicted)
Density 1.446±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -4.54±0.30(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C5H4Cl2N2O/c1-10-4-2-3(6)8-5(7)9-4/h2H,1H3
InChIKey ZSNZDRHTTWBNGI-UHFFFAOYSA-N
SMILES C1(Cl)=NC(OC)=CC(Cl)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H317-H351b
Precautionary statements  P201-P202-P261-P272-P280g-P302+P352-P308+P313-P363-P403-P501c
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
HS Code  2933599590

2,4-Dichloro-6-methoxypyrimidine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 420157 2,4-Dichloro-6-methoxypyrimidine 43212-41-5 100mg $319 2026-06-03 Buy
Usbiological 420157 2,4-Dichloro-6-methoxypyrimidine 43212-41-5 250mg $425 2026-06-03 Buy
Activate Scientific AS31290 2,4-Dichloro-6-methoxypyrimidine 97% 43212-41-5 1g $39 2026-06-04 Buy
Activate Scientific AS31290 2,4-Dichloro-6-methoxypyrimidine 97% 43212-41-5 5g $135 2026-06-04 Buy
Activate Scientific AS31290 2,4-Dichloro-6-methoxypyrimidine 97% 43212-41-5 25g $598 2026-06-04 Buy
Product number Packaging Price Buy
420157 100mg $319 Buy
420157 250mg $425 Buy
AS31290 1g $39 Buy
AS31290 5g $135 Buy
AS31290 25g $598 Buy

2,4-Dichloro-6-methoxypyrimidine Chemical Properties, Uses, Production

Uses

2,4-Dichloro-6-methoxypyrimidine is an intermediate used to prepare piperazinyl pyrimidine derivatives as γ-secretase modulators. It is also used in the synthesis of α-azinylalkylamino-substituted (thiazolylamino)pyrimidines and -pyrazines as selective JAK2 inhibitors.

Synthesis

6-METHOXYURACIL

29458-38-6

2,4-Dichloro-6-methoxypyrimidine

43212-41-5

General procedure for the synthesis of 2,4-dichloro-6-methoxypyrimidine from 6-methoxypyrimidine-2,4(1H,3H)-dione: 6-methoxypyrimidine-2,4(1H,3H)-dione (15 g, 0.106 mol) was mixed with phosphorus triclosan (400 ml) and heated and refluxed for 4 h. After completion of the reaction the excess of phosphorus triclosan was removed by distillation under reduced pressure. The residue was quenched with an ice-water mixture and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with water, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to afford 2,4-dichloro-6-methoxypyrimidine as an oil (5.5 g, 30% yield). Nuclear Magnetic Resonance Hydrogen Spectroscopy (NMR) data: δ 3.96 (3H, single peak), 6.63 (1H, single peak); Mass Spectrum (m/z): 179 [MH]+.

References

[1] Patent: WO2007/31745, 2007, A1. Location in patent: Page/Page column 96
[2] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1416 - 1421
[3] Patent: WO2006/109026, 2006, A1. Location in patent: Page/Page column 97
[4] Patent: WO2008/117051, 2008, A1. Location in patent: Page/Page column 29
[5] Patent: WO2016/168619, 2016, A1. Location in patent: Paragraph 00162

2,4-Dichloro-6-methoxypyrimidine Preparation Products And Raw materials

Raw materials

6-Methoxyuracil 2,4,6-Trichloropyrimidine Sodium Methoxide

Preparation Products

2,4-Dichloro-6-methoxypyrimidine Suppliers

Global Suppliers ( 112)
Supplier Tel Email Country ProdList Advantage
Shanghai Lingfu Pharmaceutical Research Co. LTD +86(21)5895 0110 19945755304 sales@chemany.com China 9981 58
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Heterochem 027-88041443 13072715837 sales@hetero-chem.com China 695 58
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Shanghai Witofly Chemical Co.,Ltd sales@witofly.com China 2853 52
Supplier Advantage
Shanghai Lingfu Pharmaceutical Research Co. LTD 58
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Heterochem 58
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Witofly Chemical Co.,Ltd 52

View Latest Price from 2,4-Dichloro-6-methoxypyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-6-methoxypyrimidine pictures 2025-06-25 2,4-Dichloro-6-methoxypyrimidine
43212-41-5
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2,4-Dichloro-6-methoxypyrimidine pictures 2024-10-22 2,4-Dichloro-6-methoxypyrimidine
43212-41-5
 1KG 99% 10kg/100kg Career Henan Chemica Co

2,4-Dichloro-6-methoxypyrimidine Spectrum

2,4-Dichloro-6-methoxypyrimidine(43212-41-5)1HNMR

43212-41-5 (2,4-Dichloro-6-methoxypyrimidine) Related Search:

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2,4-Dichloro-6-methoxypyrimidine Pyrimidine, 2,4-dichloro-6-methoxy- 2,4-Dichloro-6-methoxy-1,3-diazine 2,6-Dichloro-4-methoxypyrimidine 2,4-Dichloro-6-methoxypyrimidine,>97% 2,4-Dichloro-6-methoxypyrimidine ISO 9001：2015 REACH 43212-41-5 Heterocycle-Pyrimidine series