2-Bromo-5-fluoroanisole
- CAS No.
- 450-88-4
- Chemical Name:
- 2-Bromo-5-fluoroanisole
- Synonyms
- 1-Bromo-4-fluoro-2-methoxybenzene;BUTTPARK 87\07-62;2-BROMO-5-FLUOROANISOLE;2-Bromo-5-fluoroanisole >2-Bromo-5-fluoroanisole98+%;2-bromo-5-fluorobenzane ether;2-methoxy-4-fluorobromobenzene;2-BroMo-5-fluoroanisole, 95.0%(GC);Benzene, 1-bromo-4-fluoro-2-methoxy-;2-Bromo-5-fluoroanisole ISO 9001：2015 REACH
- CBNumber:
- CB0745262
- Molecular Formula:
- C7H6BrFO
- Molecular Weight:
- 205.02
- MDL Number:
- MFCD04973752
- MOL File:
- 450-88-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 143-145 °C |
|---|---|
| Density | 1.5983 |
| refractive index | 1.542 |
| Flash point | 90 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| color | Colorless to Light yellow |
| InChIKey | KGYXKRGMSUHYCY-UHFFFAOYSA-N |
| CAS DataBase Reference | 450-88-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H315-H302-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a-P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-36-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 29093090 | |||||||||
| NFPA 704 |
|
2-Bromo-5-fluoroanisole price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 682543 | 2-Bromo-5-fluoroanisole 99% | 450-88-4 | 5g | $179 | 2022-05-15 | Buy |
| TCI Chemical | B3875 | 2-Bromo-5-fluoroanisole >95.0%(GC) | 450-88-4 | 5g | $114 | 2026-04-30 | Buy |
| TCI Chemical | B3875 | 2-Bromo-5-fluoroanisole >95.0%(GC) | 450-88-4 | 25g | $442 | 2025-07-31 | Buy |
| Apolloscientific | PC7888 | 2-Bromo-5-fluoroanisole 96% | 450-88-4 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC7888 | 2-Bromo-5-fluoroanisole 96% | 450-88-4 | 25g | $30 | 2026-06-04 | Buy |
2-Bromo-5-fluoroanisole Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid to pale yellow liquid
Uses
2-Bromo-5-fluoroanisole is a halogenated anisole compound, the chemical reactivity of which is mainly concentrated on the bromine atom on its benzene ring. It can be used as an organic synthesis intermediate and a synthetic raw material for drug molecules. For example, literature reports that the substance can be used for the preparation of the drug molecule anacetrapib.
Synthesis
77-78-1
147460-41-1
450-88-4
a) A suspension of 2-bromo-5-fluorophenol (20.0 g, 104.7 mmol) and potassium carbonate (21.71 g, 157.1 mmol) was formed in acetone (200 mL). To this suspension dimethyl sulfate (10.90 mL, 115.2 mmol) was slowly added. The reaction mixture was stirred at 60 °C for 2 h. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in a mixture of ether (200 mL) and water (100 mL) to separate the organic phase. The organic phase was washed sequentially with 2N aqueous hydrochloric acid (50 mL) and saturated sodium bicarbonate solution (50 mL), and then dried with anhydrous magnesium sulfate. The dried organic phase was evaporated from the solvent under reduced pressure to give the light yellow oily product 2-bromo-5-fluoroanisole (21.46 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 7.45 (1H, dd, Ar-H), 6.70-6.55 (2H, m, Ar-H), 3.90 (3H, s, OCH3).
References
[1] Patent: WO2004/43903, 2004, A1. Location in patent: Page 29
[2] Patent: WO2004/43903, 2004, A1. Location in patent: Page 30
[3] Patent: WO2004/43904, 2004, A1. Location in patent: Page 28
2-Bromo-5-fluoroanisole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Lastest Price from 2-Bromo-5-fluoroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Bromo-5-fluoroanisole
450-88-4
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2022-01-15 | 2-Bromo-5-fluoroanisole
450-88-4
|
1KG | 98.4% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | 2-Bromo-5-fluoroanisole
450-88-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Bromo-5-fluoroanisole
450-88-4
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Bromo-5-fluoroanisole
450-88-4
- $0.00
- 98.4%
- Honest Joy Holdings Limited
-
- 2-Bromo-5-fluoroanisole
450-88-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
