3-Fluoroanisole
- CAS No.
- 456-49-5
- Chemical Name:
- 3-Fluoroanisole
- Synonyms
- 1-Fluoro-3-methoxybenzene;3-fluroanisole;3-Fluoroanisole;M-FLUOROANISOLE;3-Fluoroanisole>3-Fluoroanisole 99%;3-Fluoroanisole,99%;Inter-fluoro-anisole;3-Fluoroanisole, 98%+;M-FLUORO METHOXYBENZENE
- CBNumber:
- CB4298342
- Molecular Formula:
- C7H7FO
- Molecular Weight:
- 126.13
- MDL Number:
- MFCD00000335
- MOL File:
- 456-49-5.mol
- MSDS File:
- SDS
| Melting point | -35°C |
|---|---|
| Boiling point | 158 °C/743 mmHg (lit.) |
| Density | 1.104 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 111 °F |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform, Methanol |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.104 |
| BRN | 1858895 |
| InChI | InChI=1S/C7H7FO/c1-9-7-4-2-3-6(8)5-7/h2-5H,1H3 |
| InChIKey | MFJNOXOAIFNSBX-UHFFFAOYSA-N |
| SMILES | C1(F)=CC=CC(OC)=C1 |
| CAS DataBase Reference | 456-49-5(CAS DataBase Reference) |
| FDA UNII | DNQ5WQ6YZK |
| NIST Chemistry Reference | m-Fluoroanisole(456-49-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P403+P235-P501-P241-P280a-P501a | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 10 | |||||||||
| Safety Statements | 16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Flam. Liq. 3 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Fluoroanisole price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 162310 | 3-Fluoroanisole 99% | 456-49-5 | 25g | $53.4 | 2026-04-30 | Buy |
| TCI Chemical | F0254 | 3-Fluoroanisole >99.0%(GC) | 456-49-5 | 10g | $24 | 2026-04-30 | Buy |
| TCI Chemical | F0254 | 3-Fluoroanisole >99.0%(GC) | 456-49-5 | 25g | $39 | 2026-04-30 | Buy |
| Usbiological | 231905 | 3-Fluoroanisole 99+% ≥99%(assay) | 456-49-5 | 100g | $305 | 2026-06-03 | Buy |
| Usbiological | 231905 | 3-Fluoroanisole 99+% ≥99%(assay) | 456-49-5 | 250g | $446 | 2026-06-03 | Buy |
3-Fluoroanisole Chemical Properties,Uses,Production
Preparation
Methanol (3.2 mL, 79 mmol) was slowly added to a solution of KOtBu (7.4 g, 66 mmol) and dimethylformamide (15 mL), followed by the addition of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (6 mL). The solution was heated at 80°C for 30 minutes. 1,3-Difluorobenzene (2.6 mL, 26 mmol) was added to the mixture. The solution was heated again at 80°C for 3.5 hours. The reaction mixture was cooled to room temperature. The reaction mixture was washed with water and 10% brine (2 x). The reaction mixture was dried. The reaction mixture was concentrated. The obtained 3-Fluoroanisole was purified by rapid chromatography (1% EtOAc in hexane).
Chemical Properties
clear colorless to straw yellow liquid
Uses
3-Fluoroanisole is used in the preparation of tertiary benzylic nitriles.
Uses
3-Fluoroanisole was used in the synthesis of 4-fluoro-5,6-dihydroxytryptamine. It was also used in the synthesis of 3-fluoro- and 5-fluoronoradrenaline.
Synthesis Reference(s)
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
3-Fluoroanisole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huai'an Chenhui Technology Co., Ltd. | 13056011912 | jianshen1977@126.com | China | 26 | 58 |
| Shanghai Qianlai Pharmaceutical Technology Co., Ltd. | 021-57216911 13818863626;17740831186 | 482109853@qq.com | China | 461 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Lastest Price from 3-Fluoroanisole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Fluoroanisole
456-49-5
|
$9.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 3-Fluoroanisole
456-49-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-28 | 3-Fluoroanisole
456-49-5
|
$30.00-100.00 | 1kg | 99.93% | 1000kg per week | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- 3-Fluoroanisole
456-49-5
- $9.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Fluoroanisole
456-49-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Fluoroanisole
456-49-5
- $30.00-100.00
- 99.93%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
