6-Nitro-5-methyl (1H)indazole
- CAS No.
- 72521-00-7
- Chemical Name:
- 6-Nitro-5-methyl (1H)indazole
- Synonyms
- 5-Methyl-6-nitroindazole;5-methyl-6-nitro-1H-indazole;6-Nitro-5-methyl (1H)indazole;1H-Indazole, 5-methyl-6-nitro-
- CBNumber:
- CB0789747
- Molecular Formula:
- C8H7N3O2
- Molecular Weight:
- 177.16
- MDL Number:
- MFCD09026996
- MOL File:
- 72521-00-7.mol
- MSDS File:
- SDS
| Boiling point | 379.7±22.0 °C(Predicted) |
|---|---|
| Density | 1.437 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.30±0.40(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C8H7N3O2/c1-5-2-6-4-9-10-7(6)3-8(5)11(12)13/h2-4H,1H3,(H,9,10) |
| InChIKey | AZWAXIMNWVYSMP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(C)C([N+]([O-])=O)=C2)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
6-Nitro-5-methyl (1H)indazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR948085 | 5-Methyl-6-nitro-1H-indazole >97% | 72521-00-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR948085 | 5-Methyl-6-nitro-1H-indazole >97% | 72521-00-7 | 5g | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR948085 | 5-Methyl-6-nitro-1H-indazole >97% | 72521-00-7 | 25g | $126 | 2026-06-04 | Buy |
| Apolloscientific | OR948085 | 5-Methyl-6-nitro-1H-indazole >97% | 72521-00-7 | 100g | $491 | 2026-06-04 | Buy |
| Apolloscientific | OR948085 | 5-Methyl-6-nitro-1H-indazole >97% | 72521-00-7 | 500g | $2427 | 2026-06-04 | Buy |
6-Nitro-5-methyl (1H)indazole Chemical Properties, Uses, Production
Synthesis
2124-47-2
72521-00-7
The general procedure for the synthesis of 5-methyl-6-nitroindazole from 2,4-dimethyl-5-nitroaniline is as follows: 1. 2,4-dimethyl-5-nitroaniline (1.662 g, 10.00 mmol) was dissolved in glacial acetic acid (100 ml) and the mixture was cooled to 0°C. 2. Sodium nitrite solution (1 equiv, 690 mg dissolved in 2 ml of water) was slowly added while keeping the reaction temperature below 25 °C. 3. Stirring of the reaction mixture was continued for 3 hours, followed by filtration. 4. The filtrate was allowed to stand at room temperature for 3 days and then concentrated under reduced pressure. 5. The concentrated residue was diluted with water and the resulting mixture was vigorously stirred. 6. The solid product was collected by filtration, washed thoroughly with cold water and dried. 7. 7. Finally, the product was purified by fast chromatography (dichloromethane/methanol with an eluent ratio of 99:1) to give 1.030 g (58.1% yield) of 5-methyl-6-nitro-1H-indazole in solid form.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 403 - 427
[2] Patent: US2010/160373, 2010, A1. Location in patent: Page/Page column 28-29
[3] Patent: US2011/71143, 2011, A1. Location in patent: Page/Page column 37
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8413 - 8426
[5] Patent: WO2007/95124, 2007, A2. Location in patent: Page/Page column 89-90
6-Nitro-5-methyl (1H)indazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3987 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai Devinchem Ltd | 027-65318838 13646286950 | sales@devinchem.com | China | 2979 | 58 |
| Shanghai ChriChem Co., Ltd. | 021-54880687 | China | 510 | 55 | |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
View Latest Price from 6-Nitro-5-methyl (1H)indazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 6-NITRO-5-METHYL (1H)INDAZOLE
72521-00-7
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 6-NITRO-5-METHYL (1H)INDAZOLE
72521-00-7
- $1.00
- 99%
- Career Henan Chemical Co
