5-Iodo-1H-indazole
- CAS No.
- 55919-82-9
- Chemical Name:
- 5-Iodo-1H-indazole
- Synonyms
- 1H-Indazole, 5-iodo-;5-IODOINDAZOLE;5-IODO (1H)INDAZOLE;5-IODO (1H)INDAZOLE Cas: 55919-82-9
- CBNumber:
- CB3287486
- Molecular Formula:
- C7H5IN2
- Molecular Weight:
- 244.03
- MDL Number:
- MFCD07781642
- MOL File:
- 55919-82-9.mol
- MSDS File:
- SDS
| Melting point | 156 °C |
|---|---|
| Boiling point | 358.2±15.0 °C(Predicted) |
| Density | 2.082±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | Crystalline Powder |
| pka | 12.87±0.40(Predicted) |
| color | Yellow to brown to purple |
| InChI | InChI=1S/C7H5IN2/c8-6-1-2-7-5(3-6)4-9-10-7/h1-4H,(H,9,10) |
| InChIKey | CGCHCLICSHIAAM-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(I)C=C2)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280 |
| HS Code | 29339980 |
5-Iodo-1H-indazole price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS31622 | 5-Iodo-1H-indazole 98% | 55919-82-9 | 5g | $32 | 2026-06-04 | Buy |
| Activate Scientific | AS31622 | 5-Iodo-1H-indazole 98% | 55919-82-9 | 25g | $97 | 2026-06-04 | Buy |
| Activate Scientific | AS31622 | 5-Iodo-1H-indazole 98% | 55919-82-9 | 100g | $375 | 2026-06-04 | Buy |
| AK Scientific | W6980 | 5-Iodo-1H-indazole 98%(HPLC) | 55919-82-9 | 1g | $29 | 2026-06-04 | Buy |
| AK Scientific | W6980 | 5-Iodo-1H-indazole 98%(HPLC) | 55919-82-9 | 5g | $57 | 2026-06-04 | Buy |
5-Iodo-1H-indazole Chemical Properties,Uses,Production
Chemical Properties
Solid
Uses
Used as a reactant for the preparation of indazole-pyridine based protein kinase B/Akt inhibitors.
Synthesis
19335-11-6
55919-82-9
General procedure for the synthesis of 5-iodo-1H-indazole from 5-aminoindazole: 1. a solution of sodium nitrite (2.7 g, 39.1 mmol) in water (40 ml) was slowly added dropwise to a solution of 1-H-indazol-5-amine (5.2 g, 39.1 mmol) in 6 at 0 °C. 2. N hydrochloric acid (73.7 ml) was added to the above mixture at 0°C. 3. the resulting mixture was added slowly and dropwise to a solution of potassium iodide (26.9 g, 162 mmol) in water (60 ml) at 0 °C. 4. The reaction mixture was stirred at room temperature for 3 hours. 5. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (4 x 30 ml). 6. The organic phases were combined and washed sequentially with 10% w/v sodium thiosulfate solution (4 x 30 ml) and brine (2 x 30 ml). 7. The organic phase was dried with anhydrous magnesium sulfate and then concentrated to give a brown solid product. 8. Yield: 8.64 g (90% of theoretical). 9. 9. The structure of the product was confirmed by 3C-NMR (101 MHz, CDCl3, δppm): 84.4, 111.7, 125.6, 129.9, 133.4, 135.4, 139.0.
References
[1] Patent: WO2008/71451, 2008, A1. Location in patent: Page/Page column 47
[2] Patent: WO2014/170020, 2014, A1. Location in patent: Page/Page column 50
[3] Patent: US2009/156590, 2009, A1. Location in patent: Page/Page column 67; 69; 70
[4] Patent: US2012/28984, 2012, A1. Location in patent: Page/Page column 3
[5] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 164
5-Iodo-1H-indazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Gre-syn Chemical Technology Co., Ltd. | 13226079980 | 761330897@qq.com | China | 1159 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Lastest Price from 5-Iodo-1H-indazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 5-Iodo-1H-indazole
55919-82-9
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 5-Iodo-1H-indazole
55919-82-9
- $8.80
- 97%-99%
- Career Henan Chemical Co
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