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5-Amino-2H-isoquinolin-1-one

5-Amino-2H-isoquinolin-1-one Structure
5-Amino-2H-isoquinolin-1-one structure
CAS No.
93117-08-9
Chemical Name:
5-Amino-2H-isoquinolin-1-one
Synonyms
5-aMinoisoquinolin-1-ol;5-AIQ;5-AIQ, 10 mM in DMSO;5-Aminoisoquinolin-1(2H);5-AMino-2H-isoquinolin-1-ol;5-amino-2H-isoquinoin-1-one;5-aMinoisoquinolin-1(2H)-one;5-Amino-1(2H)-isoquinolinone;5-Amino-2H-isoquinolin-1-one;1(2H)-Isoquinolinone, 5-aMino-
CBNumber:
CB0842750
Molecular Formula:
C9H8N2O
Molecular Weight:
160.17
MDL Number:
MFCD06198896
MOL File:
93117-08-9.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:31
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5-Amino-2H-isoquinolin-1-one Properties

Melting point 249-250°C
Density 1.287
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Light Beige to Light Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2933499090

5-Amino-2H-isoquinolin-1-one price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-A612905-25MG 5-Amino-2H-isoquinolin-1-one 93117-08-9 25mg $65 2026-06-03 Buy
AstaTech CL1034 5-AMINOISOQUINOLIN-1(2H)-ONE 97% 93117-08-9 0.25G $54 2026-04-30 Buy
ChemScene CS-W006566 5-AIQ ≥98% 93117-08-9 250mg $38 2026-06-04 Buy
ChemScene CS-W006566 5-AIQ ≥98% 93117-08-9 1g $119 2026-06-04 Buy
ChemScene CS-W006566 5-AIQ ≥98% 93117-08-9 5g $360 2026-06-04 Buy
Product number Packaging Price Buy
TRC-A612905-25MG 25mg $65 Buy
CL1034 0.25G $54 Buy
CS-W006566 250mg $38 Buy
CS-W006566 1g $119 Buy
CS-W006566 5g $360 Buy

5-Amino-2H-isoquinolin-1-one Chemical Properties, Uses, Production

Uses

5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.

Definition

ChEBI: 5-amino-2H-isoquinolin-1-one is a member of isoquinolines.

Synthesis

5-NITRO-1(2H)-ISOQUINOLINONE

82827-08-5

5-AMINO-2H-ISOQUINOLIN-1-ONE

93117-08-9

General procedure for the synthesis of 5-amino-1(2H)-isoquinolinone from 5-nitro-1(2H)-isoquinolinone: To a reaction flask was added 378.3 mg (1.51 mmol) of 5-nitroisoquinolin-1(2H)-one, 376.5 mg of ammonium chloride, 2.6 mL of water and a solvent mixture of 14 mL of ethanol and 5.4 mL of tetrahydrofuran. 1.23 g of zinc powder was added in batches at 30 to 35 °C and the reaction was stirred continuously for 2 hours. Upon completion of the reaction, the reaction mixture was filtered by pumping through a glass fiber filter and the filter cake was washed with ethyl acetate. The filtrates were combined and washed sequentially with water and saturated sodium chloride solution, and then the organic phase was treated as usual. Finally, the desiccant was removed by filtration and the solvent was removed by concentration under reduced pressure to afford 196.5 mg (88.1% yield) of the target product 5-amino-1(2H)-isoquinolinone. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=5.6 (2H), 6.68 (1H), 6.87-7.45 (1H), 7.00 (1H), 7.17 (1H), 7.39 (1H), 11.7 (1H).

in vivo

5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test[1]. 5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver[2].

Animal Model:Male mice[1]
Dosage:150 and 250 mg/kg
Administration:Oral administration; 150 and 250 mg/kg; once
Result:Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.
Animal Model:Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) [2]
Dosage:3 mg/kg
Administration:Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia
Result:Reduced PARP activation and showed less staining for ICAM-1.

References

[1] Patent: WO2005/35518, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/34939, 2005, A1. Location in patent: Page/Page column 56
[3] Patent: US2005/131226, 2005, A1. Location in patent: Page/Page column 8-9
[4] Patent: US2005/222154, 2005, A1. Location in patent: Page/Page column 16

5-Amino-2H-isoquinolin-1-one synthesis

82827-08-5
93117-08-9
Synthesis of 5-Amino-2H-isoquinolin-1-one from 5-Nitro-1(2H)-isoquinolinone

5-Amino-2H-isoquinolin-1-one Preparation Products And Raw materials

Raw materials

5-Nitro-1(2H)-isoquinolinone ZINC Tetrahydrofuran Ethanol Water
Ammonium chloride

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Preparation Products

5-Amino-2H-isoquinolin-1-one Suppliers

Global Suppliers ( 99)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Record Tech (Shanghai) Co., LTD 13761627472 183009664@qq.com China 659 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Chimica Laboratories Co., Ltd 0086-573-82585213 bai@chimicalabs.com China 861 64
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Accela ChemBio Co.,Ltd. 64
Record Tech (Shanghai) Co., LTD 62
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Nanjing Vital Chemical Co., Ltd. 65
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Chimica Laboratories Co., Ltd 64
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55

View Latest Price from 5-Amino-2H-isoquinolin-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-AMINO-2H-ISOQUINOLIN-1-ONE pictures 2026-08-20 5-AMINO-2H-ISOQUINOLIN-1-ONE
93117-08-9
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
5-AIQ pictures 2026-08-08 5-AIQ
93117-08-9
 $29.00 95.95% 10g TargetMol Chemicals Inc.
5-AMINO-2H-ISOQUINOLIN-1-ONE pictures 2026-06-30 5-AMINO-2H-ISOQUINOLIN-1-ONE
93117-08-9
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
  • 5-AIQ pictures
  • 5-AIQ
    93117-08-9
  • $29.00
  • 95.95%
  • TargetMol Chemicals Inc.

5-Amino-2H-isoquinolin-1-one Spectrum

5-AMINO-2H-ISOQUINOLIN-1-ONE(93117-08-9)1HNMR

93117-08-9 (5-Amino-2H-isoquinolin-1-one) Related Search:

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1(2H)-Isoquinolinone,5-amino-(9CI) 5-amino-2H-isoquinoin-1-one 5-Amino-1(2H)-isoquinolinone 5-aMinoisoquinolin-1(2H)-one 5-aMino-1,2-dihydroisoquinolin-1-one 1(2H)-Isoquinolinone, 5-aMino- 5-Aminoisoquinolin-1(2H) 5-aMinoisoquinolin-1-ol/5-aMinoisoquinolin-1(2H)-one 5-AMino-2H-isoquinolin-1-ol 5-AMINO-2H-ISOQUINOLIN-1-ONE ISO 9001：2015 REACH 5-AIQ 5 amino 1,2 dihydroisoquinolin 1 one,5amino1,2dihydroisoquinolin1one 5-amino-1 (2H) - Isoquinoline one 5-AIQ, 10 mM in DMSO 5-aMinoisoquinolin-1-ol 5-Amino-2H-isoquinolin-1-one 93117-08-9 ISOQUINOLINE