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ChemicalBook >> CAS DataBase List >>5-AMINO-2H-ISOQUINOLIN-1-ONE

5-AMINO-2H-ISOQUINOLIN-1-ONE

5-AMINO-2H-ISOQUINOLIN-1-ONE Structure
5-AMINO-2H-ISOQUINOLIN-1-ONE structure
CAS No.
93117-08-9
Chemical Name:
5-AMINO-2H-ISOQUINOLIN-1-ONE
Synonyms
5-AIQ;5-AIQ, 10 mM in DMSO;5-aMinoisoquinolin-1-ol;5-Aminoisoquinolin-1(2H);5-AMino-2H-isoquinolin-1-ol;5-amino-2H-isoquinoin-1-one;5-AMINO-2H-ISOQUINOLIN-1-ONE;5-aMinoisoquinolin-1(2H)-one;5-Amino-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-aMino-
CBNumber:
CB0842750
Molecular Formula:
C9H8N2O
Molecular Weight:
160.17
MDL Number:
MFCD06198896
MOL File:
93117-08-9.mol
MSDS File:
SDS
Last updated:2026-02-02 18:10:39
Product description Number Pack Size Price
5-Amino-2H-isoquinolin-1-one A612905 250mg $130
5-Amino-2H-isoquinolin-1-ol 90% A12854 1g $150
5-AIQ 99.44% CS-W006566 100mg $70
5-AIQ 99.44% CS-W006566 250mg $111
5-Amino-2H-isoquinoin-1-one 95+% 074475 1g $416
Request For Quotation

5-AMINO-2H-ISOQUINOLIN-1-ONE Properties

Melting point 249-250°C
Density 1.287
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Light Beige to Light Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2933499090

5-AMINO-2H-ISOQUINOLIN-1-ONE price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A612905 5-Amino-2H-isoquinolin-1-one 93117-08-9 250mg $130 2021-12-16 Buy
Frontier Specialty Chemicals A12854 5-Amino-2H-isoquinolin-1-ol 90% 93117-08-9 1g $150 2021-12-16 Buy
ChemScene CS-W006566 5-AIQ 99.44% 93117-08-9 100mg $70 2021-12-16 Buy
ChemScene CS-W006566 5-AIQ 99.44% 93117-08-9 250mg $111 2021-12-16 Buy
Matrix Scientific 074475 5-Amino-2H-isoquinoin-1-one 95+% 93117-08-9 1g $416 2021-12-16 Buy
Product number Packaging Price Buy
A612905 250mg $130 Buy
A12854 1g $150 Buy
CS-W006566 100mg $70 Buy
CS-W006566 250mg $111 Buy
074475 1g $416 Buy

5-AMINO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Uses,Production

Uses

5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.

Definition

ChEBI: 5-amino-2H-isoquinolin-1-one is a member of isoquinolines.

Synthesis

5-NITRO-1(2H)-ISOQUINOLINONE

82827-08-5

5-AMINO-2H-ISOQUINOLIN-1-ONE

93117-08-9

General procedure for the synthesis of 5-amino-1(2H)-isoquinolinone from 5-nitro-1(2H)-isoquinolinone: To a reaction flask was added 378.3 mg (1.51 mmol) of 5-nitroisoquinolin-1(2H)-one, 376.5 mg of ammonium chloride, 2.6 mL of water and a solvent mixture of 14 mL of ethanol and 5.4 mL of tetrahydrofuran. 1.23 g of zinc powder was added in batches at 30 to 35 °C and the reaction was stirred continuously for 2 hours. Upon completion of the reaction, the reaction mixture was filtered by pumping through a glass fiber filter and the filter cake was washed with ethyl acetate. The filtrates were combined and washed sequentially with water and saturated sodium chloride solution, and then the organic phase was treated as usual. Finally, the desiccant was removed by filtration and the solvent was removed by concentration under reduced pressure to afford 196.5 mg (88.1% yield) of the target product 5-amino-1(2H)-isoquinolinone. The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ=5.6 (2H), 6.68 (1H), 6.87-7.45 (1H), 7.00 (1H), 7.17 (1H), 7.39 (1H), 11.7 (1H).

in vivo

5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test[1]. 5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver[2].

Animal Model:Male mice[1]
Dosage:150 and 250 mg/kg
Administration:Oral administration; 150 and 250 mg/kg; once
Result:Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.
Animal Model:Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) [2]
Dosage:3 mg/kg
Administration:Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia
Result:Reduced PARP activation and showed less staining for ICAM-1.

References

[1] Patent: WO2005/35518, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: WO2005/34939, 2005, A1. Location in patent: Page/Page column 56
[3] Patent: US2005/131226, 2005, A1. Location in patent: Page/Page column 8-9
[4] Patent: US2005/222154, 2005, A1. Location in patent: Page/Page column 16

5-AMINO-2H-ISOQUINOLIN-1-ONE synthesis

82827-08-5
93117-08-9
Synthesis of 5-AMINO-2H-ISOQUINOLIN-1-ONE from 5-NITRO-1(2H)-ISOQUINOLINONE

5-AMINO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials

Raw materials

5-NITRO-1(2H)-ISOQUINOLINONE ZINC Tetrahydrofuran Ethanol Water
Ammonium chloride

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Preparation Products

5-AMINO-2H-ISOQUINOLIN-1-ONE Suppliers

Global( 96)Suppliers
Supplier Tel Email Country ProdList Advantage
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Chengdu Aslee Biopharmaceuticals, Inc. 		28-85305008 CHINA 964 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 19282 58
Supplier Advantage
Accela ChemBio Inc. 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Chengdu Aslee Biopharmaceuticals, Inc. 		58
TargetMol Chemicals Inc. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dideu Industries Group Limited 		58

View Lastest Price from 5-AMINO-2H-ISOQUINOLIN-1-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-AIQ pictures 2026-02-02 5-AIQ
93117-08-9
 US $32.00-29.00 / mg 95.95% 10g TargetMol Chemicals Inc.
5-AMINO-2H-ISOQUINOLIN-1-ONE pictures 2025-12-01 5-AMINO-2H-ISOQUINOLIN-1-ONE
93117-08-9
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
5-AMINO-2H-ISOQUINOLIN-1-ONE pictures 2025-11-18 5-AMINO-2H-ISOQUINOLIN-1-ONE
93117-08-9
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
  • 5-AIQ pictures
  • 5-AIQ
    93117-08-9
  • US $32.00-29.00 / mg
  • 95.95%
  • TargetMol Chemicals Inc.

5-AMINO-2H-ISOQUINOLIN-1-ONE Spectrum

5-AMINO-2H-ISOQUINOLIN-1-ONE(93117-08-9)1HNMR

93117-08-9(5-AMINO-2H-ISOQUINOLIN-1-ONE)Related Search:

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5-Amino-1,4-benzodioxane 5-aMino-6-chloronicotinaldehyde 5-Amino-1-chloroisoquinoline 2-BROMOPYRIMIDIN-5-AMINE 5-AMINO-2,4-DIFLUOROPHENOL
5-AMINO-PYRAZINE-2-CARBOXYLIC ACID Ethyl 5-amino-2-pyridinecarboxylate 5- amino-7-azaindole methyl 5-amino-2-chloroisonicotinate 5-AIQ HYDROCHLORIDE
5-NITRO-1(2H)-ISOQUINOLINONE 5-AMINO-2H-ISOQUINOLIN-1-ONE 2-allyl-5-nitro-1(2H)-isoquinolinone

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5-AMINO-2H-ISOQUINOLIN-1-ONE 1(2H)-Isoquinolinone,5-amino-(9CI) 5-amino-2H-isoquinoin-1-one 5-aMinoisoquinolin-1-ol 5-Amino-1(2H)-isoquinolinone 5-aMinoisoquinolin-1(2H)-one 5-aMino-1,2-dihydroisoquinolin-1-one 1(2H)-Isoquinolinone, 5-aMino- 5-Aminoisoquinolin-1(2H) 5-aMinoisoquinolin-1-ol/5-aMinoisoquinolin-1(2H)-one 5-AMino-2H-isoquinolin-1-ol 5-AMINO-2H-ISOQUINOLIN-1-ONE ISO 9001：2015 REACH 5-AIQ 5 amino 1,2 dihydroisoquinolin 1 one,5amino1,2dihydroisoquinolin1one 5-amino-1 (2H) - Isoquinoline one 5-AIQ, 10 mM in DMSO 93117-08-9 ISOQUINOLINE