bicozamycin
- CAS No.
- 38129-37-2
- Chemical Name:
- bicozamycin
- Synonyms
- C11259;WS-4545;ICOZAMYCIN;bicozamycin;BicycloMycin;BicozaMycin benzoate;BicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879;(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione;2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
- CBNumber:
- CB0895983
- Molecular Formula:
- C12H18N2O7
- Molecular Weight:
- 302.28
- MDL Number:
- MOL File:
- 38129-37-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.) |
|---|---|
| alpha | D23 +63.5° (methanol) |
| Boiling point | 786.6±60.0 °C(Predicted) |
| Density | 1.57±0.1 g/cm3(Predicted) |
| pka | 9.85±0.60(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | J03U9E2P82 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Toxicity | LD50 in mice: >4 g/kg (Williams, Durham) |
bicozamycin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AB61701 | Bicozamycin | 38129-37-2 | 0.5mg | $733.72 | 2026-06-04 | Buy |
| Biosynth | AB61701 | Bicozamycin | 38129-37-2 | 1mg | $1008.87 | 2026-06-04 | Buy |
| Biosynth | AB61701 | Bicozamycin | 38129-37-2 | 2mg | $1650.86 | 2026-06-04 | Buy |
| Biosynth | AB61701 | Bicozamycin | 38129-37-2 | 5mg | $3176.25 | 2026-06-04 | Buy |
| Biosynth | AB61701 | Bicozamycin | 38129-37-2 | 10mg | $4331.3 | 2026-06-04 | Buy |
bicozamycin Chemical Properties, Uses, Production
Uses
Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.
Definition
ChEBI: A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.
Origin
Bicozamycin, formerly called bicyclomycin, was found independently in 1972, in the cul ture broth of Streptomyces sapporonensisbyFu jisawa Pharmaceuticals Industries and in that of S. aizuensis by Miyamura et al. of Ni igata University.
Biological Activity
Bicozamycin has a unique bicyclic structure and shows activity against Kleb siella, Salmonella, and Shigella but noneagainst other gram-negative bacteria or gram-positive microorganisms.
Safety
Bicozamycin is not absorbed orally and showsverylowtoxicity;nomicedied following its intravenous injection at a dose as high as two grams per kilogram.
bicozamycin Preparation Products And Raw materials
Raw materials
Preparation Products
bicozamycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15030 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8857 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
