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Cyclo(-Leu-Gly)

CAS No.
5845-67-0
Chemical Name:
Cyclo(-Leu-Gly)
Synonyms
C(LEU-GLY);c(Gly-Leu);Cyclo(Gly-Leu-);Cyclo(-Leu-Gly);CYCLO(L-LEU-GLY);CYCLO(GLY-L-LEU);Cyclo(L-leucylglycyl);Cyclo(glycyl-L-leucyl);MORPHIN, TOLERANCE PEPTIDE;MORPHINE TOLERANCE PEPTIDE
CBNumber:
CB3129160
Molecular Formula:
C8H14N2O2
Molecular Weight:
170.21
MDL Number:
MFCD00076706
MOL File:
5845-67-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:33

Cyclo(-Leu-Gly) Properties

Melting point 255℃
Boiling point 442.9±38.0 °C(Predicted)
Density 1.047
storage temp. -15°C
solubility DMSO (Sparingly), Methanol (Slightly), Water (Slightly)
form Solid
pka 13.22±0.40(Predicted)
color White to Off-White
InChI 1S/C8H14N2O2/c1-5(2)3-6-8(12)9-4-7(11)10-6/h5-6H,3-4H2,1-2H3,(H,9,12)(H,10,11)/t6-/m0/s1
InChIKey VQFHWKRNHGHZTK-LURJTMIESA-N
SMILES CC(C)C[C@@H]1NC(=O)CNC1=O
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280
Risk Statements  43
Safety Statements  36/37
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Skin Sens. 1

Cyclo(-Leu-Gly) price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS007198 Cyclo(-Leu-Gly) AldrichCPR 5845-67-0 10MG $77.9 2026-04-30 Buy
Usbiological 237003 Cyclo(Gly-L-Leu) 99+% (HPLC) ≥99%(HPLC) 100mg $273 2026-06-03 Buy
Usbiological 237003 Cyclo(Gly-L-Leu) 99+% (HPLC) ≥99%(HPLC) 250mg $420 2026-06-03 Buy
Usbiological 237003 Cyclo(Gly-L-Leu) 99+% (HPLC) ≥99%(HPLC) 1g $1042 2026-06-03 Buy
TRC TRC-C984485-50MG Cyclo(Leu-Gly) 5845-67-0 50mg $111 2026-06-03 Buy
Product number Packaging Price Buy
CDS007198 10MG $77.9 Buy
237003 100mg $273 Buy
237003 250mg $420 Buy
237003 1g $1042 Buy
TRC-C984485-50MG 50mg $111 Buy

Cyclo(-Leu-Gly) Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Cyclo(Leu-Gly) is an antimicrobial compound produced by Latobacillus plantarum.

in vivo

Cyclo(glycyl-L-leucyl) (8 mg/kg; s.c.) given 24h after apomorphine (APO) attenuates the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.)[1].

Animal Model:Male Swiss-Webster mice, 20-25g[1]
Dosage:8 mg/kg
Administration:SC; single dose given 24h after apomorphine (APO)
Result:Attenuated the DA receptor supersensitivity caused by acute high dose APO (5 mg/kg; s.c.).

IC 50

Dopamine Receptor

Cyclo(-Leu-Gly) Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclo(-Leu-Gly) Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Tianjin Derchemist Science & Technology Co., Ltd. 22-58627059 13920586291 zdcomcon@126.com China 4094 50
Dtchem Laboratories,(Gan Su)Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 773 61
ShenZhen InnoSyn Biotech Co.,Ltd 0755-28351685 18503098468 innosyn@163.com China 602 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Shenzhen Chim Biotech Co., Ltd. 13692196024 sales@chimchem.com China 500 55
Jinan Putubio Tech Co., Ltd. +86 (531) 8099-2215 putubio@outlook.com China 1256 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
C(LEU-GLY) CYCLO(GLY-L-LEU) CYCLO(L-LEU-GLY) MORPHINE TOLERANCE PEPTIDE MORPHIN, TOLERANCE PEPTIDE 2,5-Piperazinedione,3-(2-methylpropyl)-, (3S)- Cyclo(Gly-Leu-) 3-isobutylpiperazine-2,5-quinone (S)-3-(2-Methylpropyl)-2,5-piperazinedione Cyclo(glycyl-L-leucyl) L-Leucylglycine diketopiperazine Cyclo(Gly-L-Leu)≥ 99% (HPLC) (S)-3-Isobutylpiperazine-2,5-dione Cyclo(L-leucylglycyl) 3-isobutylpiperazine-2,5-dione c(Gly-Leu) Cyclo(-Leu-Gly) 5845-67-0