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ChemicalBook >> CAS DataBase List >>(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Structure
(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol structure
CAS No.
485-19-8
Chemical Name:
(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
Synonyms
reticuline;(S)-Reticuline;Reticuline (>90% ee);(S)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol;(1S)-1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol;(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol;2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol;[1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol;7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (1S)-;[1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinoline-7-ol
CBNumber:
CB0916990
Molecular Formula:
C19H23NO4
Molecular Weight:
329.39
MDL Number:
MOL File:
485-19-8.mol
MSDS File:
SDS
Last updated:2026-05-27 22:58:07
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(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Properties

Melting point 125-126°C
Boiling point 648.96°C (rough estimate)
Density 1.4371 (rough estimate)
refractive index 1.6800 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO
pka 9.95±0.10(Predicted)
form Solid
color Off-white to yellow
optical activity +88.318 (c 0.21, ethanol)
InChI InChI=1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3/t15-/m0/s1
InChIKey BHLYRWXGMIUIHG-HNNXBMFYSA-N
SMILES [C@H]1(CC2=CC=C(OC)C(O)=C2)C2=C(C=C(OC)C(O)=C2)CCN1C
FDA UNII X35Z551WT4

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 42219 (S)-Reticuline ≥98% 485-19-8 1mg $105 2026-04-30 Buy
Cayman Chemical 42219 (S)-Reticuline ≥98% 485-19-8 5mg $471 2026-04-30 Buy
Biosynth FR27708 Reticuline 485-19-8 1mg $665.5 2026-06-04 Buy
Biosynth FR27708 Reticuline 485-19-8 2mg $1081.46 2026-06-04 Buy
Biosynth FR27708 Reticuline 485-19-8 5mg $1663.75 2026-06-04 Buy
Product number Packaging Price Buy
42219 1mg $105 Buy
42219 5mg $471 Buy
FR27708 1mg $665.5 Buy
FR27708 2mg $1081.46 Buy
FR27708 5mg $1663.75 Buy

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Chemical Properties, Uses, Production

Chemical Properties

Pale Yellow Solid

Uses

Reticulin can be used to improve production of morphinan alkaloids, as well as its anti-inflammatory properties. It can also be used to lead scaffolds as PDE5A inhibitors and antihypertensives.

Uses

Precursor of many aporphine and morphine-type alkaloids.

Definition

ChEBI: The (S)-enantiomer of reticuline.

in vivo

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca2+ channel blockade and/or 3) inhibition of Ca2+ release from norepinephrine-sensitive intracellular stores[2].

IC 50

JAK2; STAT3; NF-κB; Human Endogenous Metabolite

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol synthesis

621-59-0
485-19-8
Synthesis of (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol from Isovanillin

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Preparation Products And Raw materials

Raw materials

Isoquinoline, 1,2,3,4-tetrahydro-6-methoxy-1-[[4-methoxy-3-(phenylmethoxy)phenyl]methyl]-2-methyl-7-(phenylmethoxy)-, (S)- (9CI) Cocculanorine (6CI,8CI) Isovanillin

Preparation Products

(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol Suppliers

Global Suppliers ( 94)
Supplier Tel Email Country ProdList Advantage
Chengdu Greenpure Biopharma CO.,Ltd 17311681195 zhang.liangjia@greenpurebio.com China 1615 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Shanghai Tauto Biotech Co., Ltd. 021-51320588 tauto@tautobiotech.com China 3984 66
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Shanghai Yongye Biotechnology Co., Ltd. 86-021-61559134 15921386130 3423497944@qq.com China 8135 55
Supplier Advantage
Chengdu Greenpure Biopharma CO.,Ltd 58
Chembest Research Laboratories Limited 61
Nanjing Chemlin Chemical Co., Ltd 64
BioBioPha Co., Ltd. 65
Chengdu Biopurify Phytochemicals Ltd. 60
Hangzhou Sage Chemical Co., Ltd. 58
Shanghai Tauto Biotech Co., Ltd. 66
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Finetech Industry Limited 58
Shanghai Yongye Biotechnology Co., Ltd. 55

View Latest Price from (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol pictures 2020-01-05 (S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol
485-19-8
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

485-19-8 ((S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol) Related Search:

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(S)-1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol (1S)-1-[(3-hydroxy-4-methoxy-phenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol [1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinolin-7-ol [1S,(+)]-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisoquinoline-7-ol 2-Methoxy-5-[[(1S)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydroisoquinoline]-1-ylmethyl]phenol Reticuline (>90% ee) 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-, (1S)- (S)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol (S)-Reticuline reticuline 485-19-8 CI9H2304N Amines Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals