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(-)-BETA-HYDRASTINE

(-)-BETA-HYDRASTINE Structure
(-)-BETA-HYDRASTINE structure
CAS No.
118-08-1
Chemical Name:
(-)-BETA-HYDRASTINE
Synonyms
HYDRASTINE;(-)-β-Hydrastine;l-hydrastine;Hydrastine-RM;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine
CBNumber:
CB2456153
Molecular Formula:
C21H21NO6
Molecular Weight:
383.39
MDL Number:
MFCD00152561
MOL File:
118-08-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
(1R,9S)-(?)-β-Hydrastine United States Pharmacopeia (USP) Reference Standard 1313210 10mg $632
(1R,9S)-(–)-β-Hydrastine ≥98% 22363 5mg $75
(1R,9S)-(–)-β-Hydrastine ≥98% 22363 10mg $143
(1R,9S)-(–)-β-Hydrastine ≥98% 22363 25mg $259
(1R,9S)-(–)-β-Hydrastine ≥98% 22363 50mg $442
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(-)-BETA-HYDRASTINE Properties

Melting point 132℃
alpha D20 -50° (c = 0.3 in abs alc)
Boiling point 510.32°C (rough estimate)
Density 1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.5614 (estimate)
storage temp. −20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka 7.8(at 25℃)
color White to light yellow
Water Solubility 30mg/L(20 ºC)
CAS DataBase Reference 118-08-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 8890V3217X

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
RIDADR  1544
WGK Germany  3
RTECS  MU6030000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2939800000
NFPA 704
0
3 0

(-)-BETA-HYDRASTINE price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1313210 (1R,9S)-(?)-β-Hydrastine United States Pharmacopeia (USP) Reference Standard 118-08-1 10mg $632 2026-04-30 Buy
Cayman Chemical 22363 (1R,9S)-(–)-β-Hydrastine ≥98% 118-08-1 5mg $75 2026-04-30 Buy
Cayman Chemical 22363 (1R,9S)-(–)-β-Hydrastine ≥98% 118-08-1 10mg $143 2026-04-30 Buy
Cayman Chemical 22363 (1R,9S)-(–)-β-Hydrastine ≥98% 118-08-1 25mg $259 2026-04-30 Buy
Cayman Chemical 22363 (1R,9S)-(–)-β-Hydrastine ≥98% 118-08-1 50mg $442 2026-04-30 Buy
Product number Packaging Price Buy
1313210 10mg $632 Buy
22363 5mg $75 Buy
22363 10mg $143 Buy
22363 25mg $259 Buy
22363 50mg $442 Buy

(-)-BETA-HYDRASTINE Chemical Properties,Uses,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

References

[1] SO KIM1. Effects of Hydrastine Derivatives on Dopamine Biosynthesis in PC12 Cells[J]. Planta medica, 2001, 67 1: 609-613. DOI: 10.1055/s-2001-17356
[2] SHOU YU YIN . Enantio-selective inhibition of (1R,9S)- and (1S,9R)-β-hydrastines on dopamine biosynthesis in PC12 cells[J]. Neuropharmacology, 2004, 47 7: Pages 1045-1052. DOI: 10.1016/j.neuropharm.2004.07.033
[3] SHOU YU YIN. Effects of (1R,9S)-beta-hydrastine on intracellular calcium concentration in PC12 cells.[J]. Biological & pharmaceutical bulletin, 2007, 30 8: 1547-1550. DOI: 10.1248/bpb.30.1547
[4] SHOU YU YIN. Inhibitory effects of (1R,9S)-β-hydrastine on calcium transport in PC12 cells[J]. Archives of Pharmacal Research, 2007, 30 1: 109-113. DOI: 10.1007/bf02977786

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-BETA-HYDRASTINE Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +86-18080483897 sales@biopurify.com China 4616 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9631 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Aktin Chemicals, Inc. 		028-85159085 info@aktinchem.com CHINA 1025 58
Shaanxi Didu New Materials Co. Ltd 		+86-86-17392712779 +86-13289823923 1090@dideu.com China 8651 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49709 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Mensura Group Limited 		18780014153 1058503172@qq.com China 2900 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32288 55
Supplier Advantage
Chengdu Biopurify Phytochemicals Ltd. 		58
Antai Fine Chemical Technology Co.,Limited 		58
Career Henan Chemica Co 		58
Aktin Chemicals, Inc. 		58
Shaanxi Didu New Materials Co. Ltd 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Mensura Group Limited 		58
Mainchem Co., Ltd. 55

View Lastest Price from (-)-BETA-HYDRASTINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Hydrastine pictures 2026-06-02 Hydrastine
118-08-1
 $52.00-162.00 99.92% 10g TargetMol Chemicals Inc.
  • Hydrastine pictures
  • Hydrastine
    118-08-1
  • $52.00-162.00
  • 99.92%
  • TargetMol Chemicals Inc.

(-)-BETA-HYDRASTINE Spectrum

(-)-BETA-HYDRASTINE(118-08-1)1HNMR(-)-BETA-HYDRASTINE(118-08-1)IR1(-)-BETA-HYDRASTINE(118-08-1)IR2

118-08-1((-)-BETA-HYDRASTINE)Related Search:

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NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE
NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457

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HYDRASTINE, (-)-B-(P) (AHP Verified) HYDRASTINE, (-)-B-(P) HYDRASTINE (D-beta-) (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE 9S)-β-Hydrastine N-Desmethyl &beta (+/-)-Nor-&beta Hydrastine (base and/or unspecified salts) (1R,9S)-(-)-β-Hydrastine (3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one [R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone [S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one (1R,9S)-B-hydrastine free base Hydrastinebase Hydrastine (10 mg) l-beta-Hydrastine l-hydrastine Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)- phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso quinolin-5-yl)- HYDRASTINE, (-)-B- (-)-BETA-HYDRASTINE (-)-B-HYDIASTINE (1R,9S)-(-)-BETA-HYDRASTINE (1R,9S)-BETA-HYDRASTINE [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]- 6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (1R,9S)-(–)-β-Hydrastine (-)--Hydrastine Hydrastine (1313210) (-)-Hydrastine (S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one Hydrastine,Inhibitor,inhibit Hydrastine-RM Hydrastine, 10 mM in DMSO (-)-β-Hydrastine HYDRASTINE 118-08-1 XYLOCAINE Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals