2-(methylsulphonyl)-10H-phenothiazine
- CAS No.
- 23503-68-6
- Chemical Name:
- 2-(methylsulphonyl)-10H-phenothiazine
- Synonyms
- Einecs 245-701-4;2-(Methylsulfonyl);Metopimazine Impurity 2;2-Methylsulfonyl phenothiazine;2-Methylsulfonyl-10H-phenothiazine;10H-Phenothiazine,2-(Methylsulfonyl);2-(methylsulphonyl)-10H-phenothiazine
- CBNumber:
- CB0933687
- Molecular Formula:
- C13H11NO2S2
- Molecular Weight:
- 277.36
- MDL Number:
- MFCD20926232
- MOL File:
- 23503-68-6.mol
| Melting point | 156.5-158.0 °C |
|---|---|
| Boiling point | 524.1±50.0 °C(Predicted) |
| Density | 1.363±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -3.17±0.20(Predicted) |
| color | Light Yellow to Green |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2934309090 |
| REACH Registrations | Active |
2-(methylsulphonyl)-10H-phenothiazine price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 283672 | 2-(Methylsulfonyl)-10H-phenothiazine Asreported | 23503-68-6 | 1g | $531 | 2026-06-03 | Buy |
| Usbiological | 283672 | 2-(Methylsulfonyl)-10H-phenothiazine Asreported | 23503-68-6 | 2g | $761 | 2026-06-03 | Buy |
| Usbiological | 283672 | 2-(Methylsulfonyl)-10H-phenothiazine Asreported | 23503-68-6 | 5g | $1197 | 2026-06-03 | Buy |
| Usbiological | 283672 | 2-(Methylsulfonyl)-10H-phenothiazine Asreported | 23503-68-6 | 10g | $1706 | 2026-06-03 | Buy |
| Usbiological | 283672 | 2-(Methylsulfonyl)-10H-phenothiazine Asreported | 23503-68-6 | 25g | $3186 | 2026-06-03 | Buy |
2-(methylsulphonyl)-10H-phenothiazine Chemical Properties, Uses, Production
Chemical Properties
Green Solid
Uses
Phenothiazine (P318040) derivative.
Synthesis
1628-29-1
124-63-0
23503-68-6
A mixture of aluminum trichloride (0.17 g, 1.24 mmol) and methanesulfonyl chloride (0.17 mL, 2.34 mmol) in dichloromethane (20 mL) was stirred for 15 min at 0 °C, followed by the addition of 1-(10H-phenothiazin-10-yl)ethanone (0.30 g, 1.24 mmol). The reaction mixture was stirred at room temperature for 24 h, followed by dilution with ice-cold H2O and extraction with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane/ethyl acetate (65:35, v/v) as eluent. 2-(Methylsulfonyl)-10H-phenothiazine (product 18) was obtained as a green solid in 28% (96 mg) yield; melting point: 211-215 °C (hexane/ethyl acetate); IR (ATR diamond, cm-1 ) ν: 3351, 1567, 1310, 1297; 1H NMR (400 MHz, acetone-d6) δ: 3.22 (s, 3H, CH3), 6.90 (d, J = 9 Hz, 1H, H-9), 6.98 (d, J = 9 Hz, 1H, H-6), 7.03 (t, J = 9 Hz, 1H, H-7), 7.13 (d, J = 6 Hz, 1H, H-3), 7.20 (t, J = 9 Hz, 1H, H-8), 7.58 (s, 1H H-1), 7.66 (d, J = 6 Hz, 1H, H-4), 8.55 (bs, 1H, NH); 13C NMR (100 MHz, acetone-d6) δ: 44.2 (CH3), 114.5 (CH), 115.6 (CH), 116.9 (Cq), 118.7 (Cq), 123.8 (CH), 125.9 ( CH), 126.8 (CH), 127.8 (CH), 128.4 (CH), 134.7 (Cq), 140.9 (Cq), 147.2 (Cq).HRMS (ESI): Calculated value of C13H12NO2S2 [M + H]+: 278.0309, Measured value 278.0310.
References
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 4113 - 4126
2-(methylsulphonyl)-10H-phenothiazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
View Latest Price from 2-(methylsulphonyl)-10H-phenothiazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2-(methylsulphonyl)-10H-phenothiazine
23503-68-6
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2020-01-03 | 2-(methylsulphonyl)-10H-phenothiazine
23503-68-6
|
$1.00 | 1KG | 99% | 500kg | Career Henan Chemical Co |
-
- 2-(methylsulphonyl)-10H-phenothiazine
23503-68-6
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 2-(methylsulphonyl)-10H-phenothiazine
23503-68-6
- $1.00
- 99%
- Career Henan Chemical Co
