SD-208
- CAS No.
- 627536-09-8
- Chemical Name:
- SD-208
- Synonyms
- SD-208;CS-2295;SCI 208;SD-208 10MG;SD-208 ，S7624;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;SD-208, 10 mM in DMSO;SD-208/627536-09-8/98%
- CBNumber:
- CB7837155
- Molecular Formula:
- C17H10ClFN6
- Molecular Weight:
- 352.75
- MDL Number:
- MFCD09038685
- MOL File:
- 627536-09-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 460.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.487 |
| storage temp. | 2-8°C |
| solubility | DMSO: >5mg/mL |
| form | powder |
| pka | 4.56±0.26(Predicted) |
| color | off-white to tan |
| InChI | 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) |
| InChIKey | BERLXWPRSBJFHO-UHFFFAOYSA-N |
| SMILES | Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
SD-208 price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S7071 | SD-208 ≥98% (HPLC), powder | 627536-09-8 | 5mg | $244 | 2026-04-30 | Buy |
| Sigma-Aldrich | S7071 | SD-208 ≥98% (HPLC), powder | 627536-09-8 | 25mg | $845 | 2026-04-30 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 5mg | $119 | 2026-04-30 | Buy |
| Cayman Chemical | 16619 | SD 208 ≥98% | 627536-09-8 | 10mg | $196 | 2026-04-30 | Buy |
SD-208 Chemical Properties, Uses, Production
Uses
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
in vivo
SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice[1]. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases[2]. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)[3].
storage
Store at RT
SD-208 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
